Search Results - "Zeiss, Caroline J."

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares by Goldberg, Emily L., Asher, Jennifer L., Molony, Ryan D., Shaw, Albert C., Zeiss, Caroline J., Wang, Chao, Morozova-Roche, Ludmilla A., Herzog, Raimund I., Iwasaki, Akiko, Dixit, Vishwa Deep

“…Aging and lipotoxicity are two major risk factors for gout that are linked by the activation of the NLRP3 inflammasome. Neutrophil-mediated production of…”
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Established patterns of animal study design undermine translation of disease-modifying therapies for Parkinson's disease by Zeiss, Caroline J, Allore, Heather G, Beck, Amanda P

“…Translation of disease-modifying therapies in neurodegenerative disease has been disappointing. Parkinson's disease (PD) was used to compare patterns of…”
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Modeling SARS-CoV-2 propagation using rat coronavirus-associated shedding and transmission by Zeiss, Caroline J, Asher, Jennifer L, Vander Wyk, Brent, Allore, Heather G, Compton, Susan R

“…At present, global immunity to SARS-CoV-2 resides within a heterogeneous combination of susceptible, naturally infected and vaccinated individuals. The extent…”
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Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans by Zeiss, Caroline J, Gatti, Daniel M, Toro-Salazar, Olga, Davis, Crystal, Lutz, Cathleen M, Spinale, Francis, Stearns, Timothy, Furtado, Milena B, Churchill, Gary A

“…Anthracyclines cause progressive cardiotoxicity whose ultimate severity is individual to the patient. Genetic determinants contributing to this variation are…”
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Comparative Milestones in Rodent and Human Postnatal Central Nervous System Development by Zeiss, Caroline J.

“…Within the substantially different time scales characterizing human and rodent brain development, key developmental processes are remarkably preserved. Shared…”
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Chemical entity normalization for successful translational development of Alzheimer's disease and dementia therapeutics by Mullin, Sarah, McDougal, Robert, Cheung, Kei-Hoi, Kilicoglu, Halil, Beck, Amanda, Zeiss, Caroline J

“…Identifying chemical mentions within the Alzheimer's and dementia literature can provide a powerful tool to further therapeutic research. Leveraging the…”
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Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research by Zeiss, Caroline J, Shin, Dongwook, Vander Wyk, Brent, Beck, Amanda P, Zatz, Natalie, Sneiderman, Charles A, Kilicoglu, Halil

“…Discovery studies in animals constitute a cornerstone of biomedical research, but suffer from lack of generalizability to human populations. We propose that…”
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An ABCA4 loss-of-function mutation causes a canine form of Stargardt disease by Mäkeläinen, Suvi, Gòdia, Marta, Hellsand, Minas, Viluma, Agnese, Hahn, Daniela, Makdoumi, Karim, Zeiss, Caroline J, Mellersh, Cathryn, Ricketts, Sally L, Narfström, Kristina, Hallböök, Finn, Ekesten, Björn, Andersson, Göran, Bergström, Tomas F

“…Autosomal recessive retinal degenerative diseases cause visual impairment and blindness in both humans and dogs. Currently, no standard treatment is available,…”
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Prior Influenza Infection Mitigates SARS-CoV-2 Disease in Syrian Hamsters by Di Pietro, Caterina, Haberman, Ann M, Lindenbach, Brett D, Smith, Peter C, Bruscia, Emanuela M, Allore, Heather G, Vander Wyk, Brent, Tyagi, Antariksh, Zeiss, Caroline J

“…Seasonal infection rates of individual viruses are influenced by synergistic or inhibitory interactions between coincident viruses. Endemic patterns of…”
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Mutation of POLB Causes Lupus in Mice by Senejani, Alireza G., Liu, Yanfeng, Kidane, Dawit, Maher, Stephen E., Zeiss, Caroline J., Park, Hong-Jae, Kashgarian, Michael, McNiff, Jennifer M., Zelterman, Daniel, Bothwell, Alfred L.M., Sweasy, Joann B.

“…A replication study of a previous genome-wide association study (GWAS) suggested that a SNP linked to the POLB gene is associated with systemic lupus…”
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Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS by Wang, Jiou, Farr, George W, Zeiss, Caroline J, Rodriguez-Gil, Diego J, Wilson, Jean H, Furtak, Krystyna, Rutkowski, D. Thomas, Kaufman, Randal J, Ruse, Cristian I, Yates, John R. III, Perrin, Steve, Feany, Mel B, Horwich, Arthur L

“…Recent studies suggest that superoxide dismutase 1 (SOD1)-linked amyotrophic lateral sclerosis results from destabilization and misfolding of mutant forms of…”
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Clostridium perfringens enterotoxin C‐terminal domain labeled to fluorescent dyes for in vivo visualization of micrometastatic chemotherapy‐resistant ovarian cancer by Cocco, Emiliano, Shapiro, Erik M., Gasparrini, Sara, Lopez, Salvatore, Schwab, Carlton L., Bellone, Stefania, Bortolomai, Ileana, Sumi, Natalia J., Bonazzoli, Elena, Nicoletti, Roberta, Deng, Yang, Saltzman, W. Mark, Zeiss, Caroline J., Centritto, Floriana, Black, Jonathan D., Silasi, Dan‐Arin, Ratner, Elena, Azodi, Masoud, Rutherford, Thomas J., Schwartz, Peter E., Pecorelli, Sergio, Santin, Alessandro D.

“…Identification of micrometastatic disease at the time of surgery remains extremely challenging in ovarian cancer patients. We used fluorescence microscopy, an…”
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Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice by Kim, Jung Dae, Toda, Chitoku, D'Agostino, Giuseppe, Zeiss, Caroline J., DiLeone, Ralph J., Elsworth, John D., Kibbey, Richard G., Chan, Owen, Harvey, Brandon K., Richie, Christopher T., Savolainen, Mari, Myöhännen, Timo, Jeong, Jin Kwon, Diano, Sabrina

“…Prolyl endopeptidase (PREP) has been implicated in neuronal functions. Here we report that hypothalamic PREP is predominantly expressed in the ventromedial…”
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Utility of spontaneous animal models of Alzheimer’s disease in preclinical efficacy studies by Zeiss, Caroline J.

“…Spontaneous animal models of Alzheimer’s disease (AD) offer the potential to bridge the translational gulf between promising rodent studies and failed human…”
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Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing by Rindflesch, Thomas C, Blake, Catherine L, Cairelli, Michael J, Fiszman, Marcelo, Zeiss, Caroline J, Kilicoglu, Halil

“…Structured electronic health records are a rich resource for identifying novel correlations, such as co-morbidities and adverse drug reactions. For drug…”
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MyD88 deficiency markedly worsens tissue inflammation and bacterial clearance in mice infected with Treponema pallidum, the agent of syphilis by Silver, Adam C, Dunne, Dana W, Zeiss, Caroline J, Bockenstedt, Linda K, Radolf, Justin D, Salazar, Juan C, Fikrig, Erol

“…Research on syphilis, a sexually transmitted infection caused by the non-cultivatable spirochete Treponema pallidum, has been hampered by the lack of an inbred…”
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Enhanced Ovarian Cancer Tumorigenesis and Metastasis by the Macrophage Colony-Stimulating Factor by Toy, Eugene P., Azodi, Masoud, Folk, Nancy L., Zito, Christina M., Zeiss, Caroline J., Chambers, Setsuko K.

“…Coexpression of the macrophage colony-stimulating factor (CSF-1) and its receptor (CSF-1R) in metastatic ovarian cancer specimens is a predictor of poor…”
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Improving the predictive value of interventional animal models data by Zeiss, Caroline J.

“…•448 interventions across 752 human and animal studies for Alzheimer's disease were compared.•A networks-based systems biology approach was used to assess…”
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Animal Models of COVID-19. I. Comparative Virology and Disease Pathogenesis by Zeiss, Caroline J, Compton, Susan, Veenhuis, Rebecca Terilli

“…Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has fueled unprecedented development of animal models to understand disease pathogenesis, test…”
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Animal Models of COVID-19 II. Comparative Immunology by Veenhuis, Rebecca T, Zeiss, Caroline J

“…Abstract Developing strong animal models is essential for furthering our understanding of how the immune system functions in response to Severe Acute…”
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