Search Results - "Zeisel, SH"

Epigenetic mechanisms for nutrition determinants of later health outcomes by Zeisel, Steven H

“…Epigenetic marking on genes can determine whether or not genes are expressed. Epigenetic regulation is mediated by the addition of methyl groups to DNA…”
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Choline deficiency selects for resistance to p53-independent apoptosis and causes tumorigenic transformation of rat hepatocytes by ZEISEL, S. H, ALBRIGHT, C. D, SHIN, O.-H, MAR, M.-H, SALGANIK, R. I, DA COSTA, K.-A

“…The mechanisms which drive initiated cells to progress to form carcinomas are poorly understood. CWSV-1 rat hepatocytes, in which p53 protein is inactivated by…”
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Nutrition in pregnancy: the argument for including a source of choline by Zeisel, Steven H

“…Women, during pregnancy and lactation, should eat foods that contain adequate amounts of choline. A mother delivers large amounts of choline across the…”
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Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline by Niculescu, Mihai D, Zeisel, Steven H

“…DNA methylation influences the expression of some genes and depends upon the availability of methyl groups from S-adenosylmethionine (SAM). Dietary methyl…”
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Genetic polymorphisms in methyl-group metabolism and epigenetics: Lessons from humans and mouse models by Zeisel, Steven H

“…Abstract Choline is an essential nutrient that is critical during fetal brain development. Choline deficiency, through disturbing methyl metabolism, may alter…”
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Choline and choline esters in human and rat milk and in infant formulas by Holmes-McNary, MQ, Cheng, WL, Mar, MH, Fussell, S, Zeisel, SH

“…Large amounts of choline are required in neonates for rapid organ growth and membrane biosynthesis. Human infants derive much of their choline from milk. In…”
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Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes by Resseguie, Mary, Song, Jiannan, Niculescu, Mihai D, da Costa, Kerry-Ann, Randall, Thomas A, Zeisel, Steven H

“…Choline is an essential nutrient for humans, though some of the requirement can be met by endogenous synthesis catalyzed by phosphatidylethanolamine…”
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Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains by Niculescu, Mihai D, Craciunescu, Corneliu N, Zeisel, Steven H

“…The availability of choline during critical periods of fetal development alters hippocampal development and affects memory function throughout life. Choline…”
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Concentrations of choline-containing compounds and betaine in common foods by Zeisel, Steven H, Mar, Mei-Heng, Howe, Juliette C, Holden, Joanne M

“…Choline is important for normal membrane function, acetylcholine synthesis and methyl group metabolism; the choline requirement for humans is 550 mg/d for men…”
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Perinatal Choline Influences Brain Structure and Function by Zeisel, Steven H, Niculescu, Mihai D

“…Choline is derived not only from the diet, but also from de novo synthesis. It is important for methylgroup metabolism, the formation of membranes, kidney…”
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Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study by Cho, Eunyoung, Zeisel, Steven H, Jacques, Paul, Selhub, Jacob, Dougherty, Lauren, Colditz, Graham A, Willett, Walter C

“…BACKGROUND:Epidemiologic studies of choline and betaine intakes have been sparse because a food-composition database was not available until recently. The…”
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Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD) by Song, Jiannan, da Costa, Kerry Ann, Fischer, Leslie M, Kohlmeier, Martin, Kwock, Lester, Wang, Shuli, Zeisel, Steven H

“…Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes phosphatidylcholine synthesis. PEMT knockout mice have fatty livers, and it is possible that, in…”
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Status of nutrition education in medical schools by Adams, Kelly M, Lindell, Karen C, Kohlmeier, Martin, Zeisel, Steven H

“…BACKGROUND: Numerous entreaties have been made over the past 2 decades to improve the nutrition knowledge and skills of medical students and physicians…”
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Choline: an essential nutrient for humans by Zeisel, Steven H

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Common genetic polymorphisms affect the human requirement for the nutrient choline by Costa, Kerry-Ann, Kozyreva, Olga G., Song, Jiannan, Galanko, Joseph A., Fischer, Leslie M., Zeisel, Steven H.

“…ABSTRACT Humans eating diets deficient in the essential nutrient choline can develop organ dysfunction. We hypothesized that common single nucleotide…”
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Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans by Kohlmeier, M, da Costa, K.A, Fischer, L.M, Zeisel, S.H

“…Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not. Endogenous choline synthesis can spare some…”
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Choline, homocysteine, and pregnancy by Zeisel, Steven H

“…Choline is a dietary component essential for the structural integrity and signaling functions of cell membranes; it directly affects cholinergic…”
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Quantitation of Choline and Its Metabolites in Tissues and Foods by Liquid Chromatography/Electrospray Ionization-Isotope Dilution Mass Spectrometry by Koc, Hasan, Mar, Mei-Heng, Ranasinghe, Asoka, Swenberg, James A, Zeisel, Steven H

“…Choline is important for normal membrane function, acetylcholine synthesis, lipid transport, and methyl metabolism. The U.S. National Academy of Sciences…”
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Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice by Watkins, Steven M, Zhu, Xiaonan, Zeisel, Steven H

“…Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one…”
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Choline deficiency in mice and humans is associated with increased plasma homocysteine concentration after a methionine load by da Costa, K.A, Gaffney, C.E, Fischer, L.M, Zeisel, S.H

“…Background: Elevated concentrations of homocysteine in blood may be an independent risk factor for the development of atherosclerosis. Elevated homocysteine…”
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