Search Results - "Zeisel, S H"

The nutritional phenotype in the age of metabolomics by Zeisel, S H, Freake, H C, Bauman, D E, Bier, D M, Burrin, D G, German, J B, Klein, S, Marquis, G S, Milner, J A, Pelto, G H, Rasmussen, K M

“…The concept of the nutritional phenotype is proposed as a defined and integrated set of genetic, proteomic, metabolomic, functional, and behavioral factors…”
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Metabolomics in the opening decade of the 21st century: building the roads to individualized health by German, J B, Bauman, D E, Burrin, D G, Failla, M L, Freake, H C, King, J C, Klein, S, Milner, J A, Pelto, G H, Rasmussen, K M, Zeisel, S H

“…It is rapidly becoming possible to measure hundreds or thousands of metabolites in small samples of biological fluids or tissues. This makes it possible to…”
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S‐Adenosylhomocysteine hydrolase deficiency: A second patient, the younger brother of the index patient, and outcomes during therapy by Barić, I., Ćuk, M., Fumić, K., Vugrek, O., Allen, R. H., Glenn, B., Maradin, M., Pažanin, L., Pogribny, I., Radoš, M., Sarnavka, V., Schulze, A., Stabler, S., Wagner, C., Zeisel, S. H., Mudd, S. H.

“…Summary S‐Adenosylhomocysteine (AdoHcy) hydrolase deficiency has been proven in a human only once, in a recently described Croatian boy. Here we report the…”
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S‐Adenosylhomocysteine hydrolase deficiency in a 26‐year‐old man by Buist, N. R. M., Glenn, B., Vugrek, O., Wagner, C., Stabler, S., Allen, R. H., Pogribny, I., Schulze, A., Zeisel, S. H., Barić, I., Mudd, S. H.

“…This paper reports the third proven human case of deficient S‐adenosylhomocysteine (AdoHcy) hydrolase activity. The patient is similar to the only two…”
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Choline and human nutrition by ZEISEL, S. H, BLUSZTAJN, J. K

“…Choline is crucial for sustaining life. It modulates the basic signaling processes within cells, is a structural element in membranes, and is vital during…”
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Choline and choline esters in human and rat milk and in infant formulas by Holmes-McNary, MQ, Cheng, WL, Mar, MH, Fussell, S, Zeisel, SH

“…Large amounts of choline are required in neonates for rapid organ growth and membrane biosynthesis. Human infants derive much of their choline from milk. In…”
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Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver by Zeisel, S H, Mar, M H, Zhou, Z, da Costa, K A

“…Choline is an important nutrient that is actively transported from mother to fetus across the placenta and from mother to infant across the mammary gland…”
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Choline phospholipids: signal transduction and carcinogenesis by Zeisel, S H

“…Phospholipids act as vital elements in transmembrane signaling. Agonist-induced hydrolysis of phosphatidylinositides has been established as a major mechanism…”
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Severe folate deficiency causes secondary depletion of choline and phosphocholine in rat liver by Kim, Y I, Miller, J W, da Costa, K A, Nadeau, M, Smith, D, Selhub, J, Zeisel, S H, Mason, J B

“…It has previously been shown that choline deficiency causes depletion of hepatic folate concentration in rats. Two separate experiments were undertaken to…”
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Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice by Salganik, Rudolf I., Albright, Craig D., Rodgers, Jerilyn, Kim, John, Zeisel, Steven H., Sivashinskiy, Mikhail S., Van Dyke, Terry A.

“…Apoptosis, or regulated cell suicide, eliminates unwanted and damaged cells, including precancerous and cancerous cells. Since reactive oxygen species (ROS)…”
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Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet by Garner, S C, Mar, M H, Zeisel, S H

“…Choline supplementation of pregnant rats between d 12 and 17 of pregnancy permanently enhances the spatial memory of offspring; however, the mechanism is…”
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Nutrition: a reservoir for integrative science by Zeisel, S H, Allen, L H, Coburn, S P, Erdman, J W, Failla, M L, Freake, H C, King, J C, Storch, J

“…In the last twenty years, powerful new molecular techniques were introduced that made it possible to advance knowledge in human biology using a reductionist…”
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Is there a metabolic basis for dietary supplementation? by ZEISEL, S. H

“…To be efficacious, dietary supplements must either provide a nutrient that is normally undersupplied to cells or exert a pharmacologic effect on cellular…”
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Choline, an essential nutrient for humans by Zeisel, S H, Da Costa, K A, Franklin, P D, Alexander, E A, Lamont, J T, Sheard, N F, Beiser, A

“…Choline is required to make essential membrane phospholipids. It is a precursor for the biosynthesis of the neurotransmitter acetylcholine and also is an…”
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Maternal methionine adenosyltransferase I/III deficiency: Reproductive outcomes in a woman with four pregnancies by Mudd, S. H., Tangerman, A., Stabler, S. P., Allen, R. H., Wagner, C., Zeisel, S. H., Levy, H. L.

“…Four pregnancies in a women with moderately severe deficiency of methionine adenosyltransferase I/III (MAT I/III) activity are reported. She is an apparent…”
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Choline: an essential nutrient for humans by Zeisel, Steven H

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Evaluation of the Potential of Triethanolamine to Alter Hepatic Choline Levels in Female B6C3F1 Mice by Stott, W. T., Radtke, B. J., Linscombe, V. A., Mar, M.-H., Zeisel, S. H.

“…Triethanolamine (TEA), a widely used nongenotoxic alcohol-amine, has recently been reported to cause an increased incidence of liver tumors in female B6C3F1…”
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Potential mechanisms of tumorigenic action of diethanolamine in mice by Stott, W.T, Bartels, M.J, Brzak, K.A, Mar, M.-H, Markham, D.A, Thornton, C.M, Zeisel, S.H

“…Diethanolamine (DEA), a secondary amine found in a number of consumer products, reportedly induces liver tumors in mice. In an attempt to define the…”
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Betaine in wine: answer to the French paradox? by Mar, Mei-Heng, Zeisel, S.H.

“…In France, a diet high in saturated fat and cholesterol is associated with low coronary artery disease mortality and it may be that drinking wine is protective…”
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Getting nutrition education into medical schools: a computer-based approach by COOKSEY, Karen, KOHLMEIER, Martin, PLAISTED, Claudia, ADAMS, Kelly, ZEISEL, Steven H

“…Despite awareness of the importance of nutrition as part of medical student's education, numerous barriers exist to incorporating nutrition education into the…”
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