Search Results - "Zeineddine, Rafaa"

Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide by Cater, Jordan H., Kumita, Janet R., Abdallah, Rafaa Zeineddine, Zhao, Guomao, Bernardo-Gancedo, Ana, Henry, Amanda, Winata, Wendy, Chi, Mengna, Grenyer, Brin S. F., Townsend, Michelle L., Ranson, Marie, Buhimschi, Catalin S., Charnock-Jones, Stephen, Dobson, Christopher M., Wilson, Mark R., Buhimschi, Irina A., Wyatt, Amy R.

“…Protein misfolding underlies the pathology of a large number of human disorders, many of which are age-related. An exception to this is preeclampsia, a leading…”
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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms by Grad, Leslie I., Yerbury, Justin J., Turner, Bradley J., Guest, William C., Pokrishevsky, Edward, O'Neill, Megan A., Yanai, Anat, Silverman, Judith M., Zeineddine, Rafaa, Corcoran, Lisa, Kumita, Janet R., Luheshi, Leila M., Yousefi, Masoud, Coleman, Bradley M., Hill, Andrew F., Plotkin, Steven S., Mackenzie, Ian R., Cashman, Neil R.

“…Amyotrophic lateral sclerosis (ALS) is predominantly sporadic, but associated with heritable genetic mutations in 5–10% of cases, including those in Cu/Zn…”
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Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype by Roberts, Kate, Zeineddine, Rafaa, Corcoran, Lisa, Li, Wen, Campbell, Iain L., Yerbury, Justin J.

“…A large body of literature suggests that amyotrophic lateral sclerosis (ALS) pathology is intimately linked with neuroinflammation, specifically activation and…”
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Hypochlorite-induced aggregation of fibrinogen underlies a novel antioxidant role in blood plasma by Mañucat-Tan, Noralyn, Zeineddine Abdallah, Rafaa, Kaur, Harsimran, Saviane, Daniel, Wilson, Mark R., Wyatt, Amy R.

“…Fibrinogen, a major constituent of blood plasma, is highly susceptible to reaction with biological oxidants. It has been proposed that fibrinogen plays a role…”
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Extracellular wildtype and mutant SOD1 induces ER–Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells by Sundaramoorthy, Vinod, Walker, Adam K, Yerbury, Justin, Soo, Kai Ying, Farg, Manal A, Hoang, Vy, Zeineddine, Rafaa, Spencer, Damian, Atkin, Julie D

“…Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodegenerative disorder and the majority of ALS is sporadic, where misfolding and…”
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Hypochlorite-induced oxidation promotes aggregation and reduces toxicity of amyloid beta 1-42 by Mañucat-Tan, Noralyn B., Chowdhury, Ashfaq, Cataldi, Rodrigo, Abdullah, Rafaa Zeineddine, Kumita, Janet R., Wyatt, Amy R.

“…Exacerbated hypochlorite (OCl−) production is linked to neurodegenerative processes, but there is growing evidence that lower levels of hypochlorite activity…”
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Flow cytometric measurement of the cellular propagation of TDP-43 aggregation by Zeineddine, Rafaa, Whiten, Daniel R., Farrawell, Natalie E., McAlary, Luke, Hanspal, Maya A., Kumita, Janet R., Wilson, Mark R., Yerbury, Justin J.

“…Amyotrophic lateral sclerosis is a devastating neuromuscular degenerative disease characterized by a focal onset of motor neuron loss, followed by contiguous…”
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The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases by Zeineddine, Rafaa, Yerbury, Justin J

“…With the onset of the rapidly aging population, the impact of age related neurodegenerative diseases is becoming a predominant health and economic concern…”
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WITHDRAWN: Corrigendum to ‘Hypochlorite-induced oxidation promotes aggregation and reduces toxicity of amyloid beta 1–42’ [Redox Biol. 63 (2023) 102736] by Mañucat-Tan, Noralyn B., Chowdhury, Ashfaq, Cataldi, Rodrigo, Abdullah, Rafaa Zeineddine, Kumita, Janet R., Wyatt, Amy R.

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Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation by Zeineddine, Rafaa, Farrawell, Natalie E., Lambert-Smith, Isabella A., Yerbury, Justin J.

“…ALS is characterised by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology throughout the nervous system, resulting in…”
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Corrigendum to 'Hypochlorite-induced oxidation promotes aggregation and reduces toxicity of amyloid beta 1-42' [Redox Biol. 63 (2023) 102736] by Mañucat-Tan, Noralyn B, Chowdhury, Ashfaq, Cataldi, Rodrigo, Abdullah, Rafaa Zeineddine, Kumita, Janet R, Wyatt, Amy R

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SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation by Zeineddine, Rafaa, Pundavela, Jay F, Corcoran, Lisa, Stewart, Elise M, Do-Ha, Dzung, Bax, Monique, Guillemin, Gilles, Vine, Kara L, Hatters, Danny M, Ecroyd, Heath, Dobson, Christopher M, Turner, Bradley J, Ooi, Lezanne, Wilson, Mark R, Cashman, Neil R, Yerbury, Justin J

“…Amyotrophic Lateral Sclerosis is characterized by a focal onset of symptoms followed by a progressive spread of pathology that has been likened to transmission…”
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