Search Results - "Zeineddine, Hussein"

Challenges of Neurosurgery Education During the Coronavirus Disease 2019 (COVID-19) Pandemic: A U.S. Perspective by Lewis, Cole T., Zeineddine, Hussein A., Esquenazi, Yoshua

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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations by Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

“…Cerebral cavernous malformations (CCMs) are a cause of stroke and seizure for which no effective medical therapies yet exist. CCMs arise from the loss of an…”
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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations by Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A, Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K, Awad, Issam A, Ginsberg, Mark H

“…mutations are the most common cause of cerebral cavernous malformation (CCM). Acute gene inactivation in mouse brain microvascular endothelial cells (BMECs)…”
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RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations by Shenkar, Robert, Shi, Changbin, Austin, Cecilia, Moore, Thomas, Lightle, Rhonda, Cao, Ying, Zhang, Lingjiao, Wu, Meijing, Zeineddine, Hussein A, Girard, Romuald, McDonald, David A, Rorrer, Autumn, Gallione, Carol, Pytel, Peter, Liao, James K, Marchuk, Douglas A, Awad, Issam A

“…BACKGROUND AND PURPOSE—We sought to compare the effect of chronic treatment with commonly tolerated doses of Fasudil, a specific RhoA kinase (ROCK) inhibitor,…”
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Cerebrovascular Complications Associated With Iatrogenic Fungal Meningitis Following Surgical Procedures in Mexico by Becerril-Gaitan, Andrea, Bindal, Shivani, Parker, Samantha L, Mullarkey, Matthew P, Zeineddine, Hussein A, Chen, Justine M, Choi, Huimahn A, Chen, Peng R, Blackburn, Spiros, Day, Arthur, Torres, Luis F, Brown, Robert J, Bowry, Ritvij, Chen, Ching-Jen

“…The current fungal meningitis outbreak caused by contaminated epidural anesthesia with among patients who underwent surgical procedures in Matamoros, Mexico…”
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Utility of Surveillance Angiography in Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study of 223 Consecutive Patients by Kole, Matthew J., Martinez-Gutierrez, Juan Carlos, Zeineddine, Hussein A., Truong, Van Thi Thanh, Chen, Peng Roc

“…Background Patients with aneurysmal subarachnoid hemorrhage (aSAH) who survive the rupture are at risk for delayed neurologic deficits and cerebral infarction…”
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Neutrophils and Neutrophil Extracellular Traps Cause Vascular Occlusion and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage in Mice by Zeineddine, Hussein A, Hong, Sung-Ha, Peesh, Pedram, Dienel, Ari, Torres, Kiara, Thankamani Pandit, Peeyush, Matsumura, Kanako, Huang, Shuning, Li, Wen, Chauhan, Anjali, Hagan, John P, Marrelli, Sean P, McCullough, Louise D, Blackburn, Spiros L, Aronowski, Jaroslaw, McBride, Devin W

“…After subarachnoid hemorrhage (SAH), neutrophils are deleterious and contribute to poor outcomes. Neutrophils can produce neutrophil extracellular traps (NETs)…”
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Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial by Polster, Sean P, Stadnik, Agnieszka, Akers, Amy L, Cao, Ying, Christoforidis, Gregory A, Fam, Maged D, Flemming, Kelly D, Girard, Romuald, Hobson, Nicholas, Koenig, James I, Koskimäki, Janne, Lane, Karen, Liao, James K, Lee, Cornelia, Lyne, Seán B, McBee, Nichol, Morrison, Leslie, Piedad, Kristina, Shenkar, Robert, Sorrentino, Matthew, Thompson, Richard E, Whitehead, Kevin J, Zeineddine, Hussein A, Hanley, Daniel F, Awad, Issam A

“…Abstract BACKGROUND More than a million Americans harbor a cerebral cavernous angioma (CA), and those who suffer a prior symptomatic hemorrhage have an…”
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Thromboelastography Indices for Predicting Outcomes After Aneurysmal Subarachnoid Hemorrhage: A Prospective Study by Zeineddine, Hussein A., Li, Wen, T, Peeyush Kumar, McBride, Devin, Dienel, Ari, Torres, Glenda, Grotta, James, Savarraj, Jude, Chang, Tiffany, Choi, Huimahn A., Dash, Pramod, Blackburn, Spiros

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Blunt Traumatic Vertebral Artery Injuries: Incidence, Therapeutic Management, and Outcomes by Zeineddine, Hussein A, King, Nicholas, Lewis, Cole T, Kole, Matthew J, Kitagawa, Ryan, Dannenbaum, Mark, Chen, Peng Roc, Day, Arthur L, Blackburn, Spiros

“…Blunt cerebrovascular injury (BCVI) is a term for injuries to the carotid and vertebral arteries (blunt vertebral artery injury [BVAI]) caused by blunt trauma…”
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Glyoxal Fixation Is Optimal for Immunostaining of Brain Vessels, Pericytes and Blood-Brain Barrier Proteins by Thomas, Sithara, Sadanandan, Jayanarayanan, Blackburn, Spiros L, McBride, Devin W, Dienel, Ari, Hong, Sungha, Zeineddine, Hussein A, Thankamani, Peeyush Kumar

“…Brain vascular staining is very important for understanding cerebrovascular pathologies. 4% paraformaldehyde is considered the gold standard fixation technique…”
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The chicken wing training model in cerebrovascular microsurgery for the side-to-side bypass by Mullarkey, Matthew P., Zeineddine, Hussein A., Honarpishesh, Pedram, Kole, Matthew J., Cochran, Joseph

“…•Describes a classic tool that allows neurosurgeons in training and junior attendings practice advanced microsurgical techniques and delves into strategy and…”
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Intracranial Approach for Retrieval of the Condylar Head After Avulsion into the Middle Cranial Fossa by Esquenazi, Yoshua, Zeineddine, Hussein A, Reimer, Eric, Stackowicz, Daniel, Demian, Nagi

“…Dislocation of the mandibular condyle into the middle cranial fossa is a rare injury that can be seen after facial trauma. Early identification of condyle…”
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Middle Meningeal Artery Embolization for Chronic Subdural Hematomas With Concurrent Antithrombotics by Martinez-Gutierrez, Juan Carlos, Zeineddine, Hussein A, Nahhas, Michael I, Kole, Matthew J, Kim, Youngran, Kim, Hyun Woo, D'Amato, Salvatore A, Chen, Peng Roc, Blackburn, Spiros L, Spiegel, Gary, Sheth, Sunil A, Kitagawa, Ryan S, Dannenbaum, Mark J

“…Chronic subdural hematoma (CSDH) is an increasingly prevalent disease in the aging population. Patients with CSDH frequently suffer from concurrent vascular…”
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Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial by Fam, Maged D, Hanley, Daniel, Stadnik, Agnieszka, Zeineddine, Hussein A, Girard, Romuald, Jesselson, Michael, Cao, Ying, Money, Lynn, McBee, Nichol, Bistran-Hall, Amanda J, Mould, W Andrew, Lane, Karen, Camarata, Paul J, Zuccarello, Mario, Awad, Issam A

“…Abstract BACKGROUND Minimally invasive thrombolytic evacuation of intracerebral hematoma is being investigated in the ongoing phase III clinical trial of…”
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Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth by Girard, Romuald, Zeineddine, Hussein A, Koskimäki, Janne, Fam, Maged D, Cao, Ying, Shi, Changbin, Moore, Thomas, Lightle, Rhonda, Stadnik, Agnieszka, Chaudagar, Kiranj, Polster, Sean, Shenkar, Robert, Duggan, Ryan, Leclerc, David, Whitehead, Kevin J, Li, Dean Y, Awad, Issam A

“…RATIONALE:The clinical course of cerebral cavernous malformations is highly unpredictable, with few cross-sectional studies correlating proinflammatory…”
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Targeting Hemoglobin to Reduce Delayed Cerebral Ischemia After Subarachnoid Hemorrhage by Zeineddine, Hussein A., Honarpisheh, Pedram, McBride, Devin, Pandit, Peeyush Kumar Thankamani, Dienel, Ari, Hong, Sung-Ha, Grotta, James, Blackburn, Spiros

“…Delayed cerebral ischemia (DCI) continues to be a sequela of aneurysmal subarachnoid hemorrhage (aSAH) that carries significant morbidity and mortality. Aside…”
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Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH) by Polster, Sean P, Cao, Ying, Carroll, Timothy, Flemming, Kelly, Girard, Romuald, Hanley, Daniel, Hobson, Nicholas, Kim, Helen, Koenig, James, Koskimäki, Janne, Lane, Karen, Majersik, Jennifer J, McBee, Nichol, Morrison, Leslie, Shenkar, Robert, Stadnik, Agnieszka, Thompson, Richard E, Zabramski, Joseph, Zeineddine, Hussein A, Awad, Issam A

“…Abstract BACKGROUND Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent…”
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Patients with cranial dural arteriovenous fistulas may benefit from expanded hypercoagulability and cancer screening by Polster, Sean P, Zeineddine, Hussein A, Baron, Joseph, Lee, Seon-Kyu, Awad, Issam A

“…Cranial dural arteriovenous fistulas (DAVFs) have been associated with dural sinus occlusion, and previous reports have suggested the association of…”
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Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations by Girard, Romuald, Fam, Maged D, Zeineddine, Hussein A, Tan, Huan, Mikati, Abdul Ghani, Shi, Changbin, Jesselson, Michael, Shenkar, Robert, Wu, Meijing, Cao, Ying, Hobson, Nicholas, Larsson, Henrik B W, Christoforidis, Gregory A, Awad, Issam A

“…OBJECTIVE Vascular permeability and iron leakage are central features of cerebral cavernous malformation (CCM) pathogenesis. The authors aimed to correlate…”
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