Search Results - "Zeid, Laila"

1,2,3-Triazole-Chalcone hybrids: Synthesis, in vitro cytotoxic activity and mechanistic investigation of apoptosis induction in multiple myeloma RPMI-8226 by Ashour, Heba F., Abou-zeid, Laila A., El-Sayed, Magda A. -A., Selim, Khalid B.

“…A new series of 1,2,3-triazole-chalcone hybrids has been synthesized and screened in vitro against a panel of 60 human cancer cell lines according to NCI (USA)…”
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Design, synthesis and docking study of novel picolinamide derivatives as anticancer agents and VEGFR-2 inhibitors by Zeidan, Mohamed A., Mostafa, Amany S., Gomaa, Rania M., Abou-zeid, Laila A., El-Mesery, Mohamed, El-Sayed, Magda A. -A., Selim, Khalid B.

“…Two series of picolinamide derivatives bearing (thio)urea and dithiocarbamate moieties were designed and synthesized as VEGFR-2 kinase inhibitors. All the new…”
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Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies by Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., ElTahir, Kamal Eldin H., Mohamed, Menshawy A., Abu El-Enin, Mohamed A., El-Azab, Adel S.

“…Compounds 4 and 6 possessed more potent analgesic and anti-inflammatory activities than celecoxib. Compounds 4 and 6 showed high COX-2 inhibitory efficacies…”
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Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones by Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., ElTahir, Kamal Eldin H., Ayyad, Rezk R., El-Sayed, Magda A.-A., El-Azab, Adel S.

“…A new series of 2-substituted mercapto-4(3H)-quinazolinone 1–26 were synthesized and assessed for in vivo anti-inflammatory and analgesic activities and…”
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Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies by Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., Abou-Zeid, Laila A., ElTahir, Kamal Eldin H., Abdel-Aziz, Naglaa I., Ayyad, Rezk R., Al-Obaid, Abdulrahman M.

“…The design, synthesis and pharmacological activities of a group of 5,5-diphenylimidazolidine-2,4-dione bearing anilide, phenacyl and benzylidene fragments 2–27…”
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Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel Pyrazolo[3,4‐d]pyrimidines as Potential Telomerase Inhibitors by Kosbar, Tamer R., Abou‐Zeid, Laila, Sofan, Mamdouh A.

“…Series of novel pyrazolo[3,4‐d]pyrimidines as potential telomerase inhibitors were synthesized. Results of the antitumor assay indicated that compounds 4b,…”
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Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones by Al-Omary, Fatmah A.M., Abou-zeid, Laila A., Nagi, Mahmoud N., Habib, El-Sayed E., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., Abdel-Hamide, Sami G., Al-Omar, Mohamed A., Al-Obaid, Abdulrahman M., El-Subbagh, Hussein I.

“…A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor…”
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Synthesis, anticancer and apoptosis-inducing activities of quinazoline-isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies by El-Azab, Adel S., Al-Dhfyan, Abdullah, Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., Alkahtani, Hamad M., Al-Obaid, Abdulrahman M., Al-Gendy, Manal A.

“…A new series of quinazolinone compounds 16-34 incorporating isatin moieties was synthesized. The antitumor efficacy of the compounds against MDA-MB-231, a…”
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Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies by El-Azab, Adel S., Abdel-Aziz, Alaa A.-M., Abou-Zeid, Laila A., El-Husseiny, Walaa M., El_Morsy, Ahmad M., El-Gendy, Manal A., El-Sayed, Magda A.-A.

“…A new series of NSAID thioesters were synthesized and evaluated for their in vitro antitumor effects against a panel of four human tumor cell lines, namely:…”
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Synthesis, Biological Evaluation and In Silico Studies of 1,2,4‐Triazole and 1,3,4‐Thiadiazole Derivatives as Antiherpetic Agents by Goma'a, Hebat‐Allah M., Ghaly, Mariam A., Abou‐zeid, Laila A., Badria, Farid A., Shehata, Ihsan A., El‐Kerdawy, Mohamed M.

“…Two isosteric series of 1,2,4‐triazole and 1,3,4‐thiadiazole derivatives were designed and synthesized in this work to be evaluated for their antiviral…”
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Design, synthesis, molecular modeling and biological evaluation of novel diaryl heterocyclic analogs as potential selective cyclooxygenase-2 (COX-2) inhibitors by Al-Turki, Deema A., Al-Omar, Mohamed A., Abou-zeid, Laila A., Shehata, Ihsan A., Al-Awady, Mohammed S.

“…New series of 3,4-diaryl-2-thioxoimidazolidin-4-ones and 3-alkylthio-4,5-diaryl-4H-1,2,4-triazoles were designed, synthesized and evaluated for their activity…”
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Computational Modeling, Synthesis, and Antioxidant Potential of Novel Phenylcarbamoylbenzoic Acid Analogs in Combating Oxidative Stress by Bayoumi, Waleed A., Elsayed, Magda A., Baraka, Hany N., Abou-zeid, Laila

“…A new series of phenylcarbamoylbenzoic acid analogs were designed, synthesized, and evaluated for their in vitro antioxidant activity, aiming to find a lead…”
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Differential recognition of resveratrol isomers by the human estrogen receptor-α: Molecular dynamics evidence for stereoselective ligand binding by Abou-Zeid, Laila A., El-Mowafy, Abdalla M.

“…Resveratrol (RSVL) is a phytoestrogen that occurs naturally in two forms (trans‐ (E) and cis‐ (Z)). We have conducted molecular dynamics (MD) studies to…”
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Predicting Secondary Progressive Multiple Sclerosis Using Blood IgG Aggregates (S42.005) by Yu, Xiaoli, Fultz, Matthew, Zeid, Laila, Zhou, Wenbo

“…Abstract only…”
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Anti-asthmatic and Antioxidant Activity of Flavonoids Isolated from Mentha longifolia subspecies typhoides (Briq.) Harley. and Mentha longifolia subspecies schimperi (Briq.) Briq. on Ovalbumin-induced Allergic Asthma in Mice: in-vivo and in-silico Study by Haikal, Abdullah, El-Neketi, Mona, Helal, Manar G., Abou-zeid, Laila A., Hassan, Madiha A., Gohar, Ahmed A.

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Docking studies, antitumor and antioxidant evaluation of newly synthesized porphyrin and metalloporphyrin derivatives by Ahmed, Asmaa, Omar, Walaa A.E., El-Asmy, Hala A., Abou-Zeid, Laila, Fadda, Ahmed A.

“…In this work, we have synthesized a series of novel porphyrin derivatives, 1–5, in high yields. The metal complexes of two of the newly synthesized porphyrin…”
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Cover Image by Kosbar, Tamer R., Abou‐Zeid, Laila, Sofan, Mamdouh A.

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Recognition of Resveratrol by the Human Estrogen Receptor-Alpha: A Molecular Modeling Approach to Understand Its Biological Actions by El-Mowafy, Abdalla M., Abou-Zeid, Laila A., Edafiogho, Ivan

“…Objectives: Resveratrol (RSVL) is an edible phytoestrogen with multifaceted health benefits that may originate from binding to the estrogen receptors. Despite…”
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Nanocomposite polymers and their applications for electromagnetic interference shielding by Naira Ali Abd Elaziz, Fatma Shaban Hafez, Aya Ashraf Muhammad Abdel Hamid, May Emad Eldin Mostafa, Tasneem Elsayed Ahmed, Islam, Omar, Zeid, Laila, Younes, Ahmed, Rewida Hamed, Dalia Nasser Zaghloul, Mohamed, Hend, Darwish, Mohamed

“…Electromagnetic pollution has increased because of technological advances and the use of telecommunication equipment and electronics. Developing a smart…”
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Combating oxidative stress as a hallmark of cancer and aging: Computational modeling and synthesis of phenylene diamine analogs as potential antioxidant by Abou-zeid, Laila, Baraka, Hany N.

“…The cross talk between the over expression of oxygen-free radicals is known as reactive oxygen species (ROS) that is associated with the excessive telomerase…”
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