Search Results - "Zeißig, Sebastian"

A global assessment of recent trends in gastrointestinal cancer and lifestyle‐associated risk factors by Lu, Lili, Mullins, Christina S., Schafmayer, Clemens, Zeißig, Sebastian, Linnebacher, Michael

“…Background Gastrointestinal (GI) cancers were responsible for 26.3% of cancer cases and 35.4% of deaths worldwide in 2018. This study aimed to analyze the…”
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Inflammatory bowel disease by Kaser, Arthur, Zeissig, Sebastian, Blumberg, Richard S

“…Insights into inflammatory bowel disease (IBD) are advancing rapidly owing to immunologic investigations of a plethora of animal models of intestinal…”
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Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4 by Junker, Yvonne, Zeissig, Sebastian, Kim, Seong-Jun, Barisani, Donatella, Wieser, Herbert, Leffler, Daniel A, Zevallos, Victor, Libermann, Towia A, Dillon, Simon, Freitag, Tobias L, Kelly, Ciaran P, Schuppan, Detlef

“…Ingestion of wheat, barley, or rye triggers small intestinal inflammation in patients with celiac disease. Specifically, the storage proteins of these cereals…”
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Loss of hepatic Mboat7 leads to liver fibrosis by Thangapandi, Veera Raghavan, Knittelfelder, Oskar, Brosch, Mario, Patsenker, Eleonora, Vvedenskaya, Olga, Buch, Stephan, Hinz, Sebastian, Hendricks, Alexander, Nati, Marina, Herrmann, Alexander, Rekhade, Devavrat Ravindra, Berg, Thomas, Matz-Soja, Madlen, Huse, Klaus, Klipp, Edda, Pauling, Josch K, Wodke, Judith Ah, Miranda Ackerman, Jacobo, Bonin, Malte von, Aigner, Elmar, Datz, Christian, von Schönfels, Witigo, Nehring, Sophie, Zeissig, Sebastian, Röcken, Christoph, Dahl, Andreas, Chavakis, Triantafyllos, Stickel, Felix, Shevchenko, Andrej, Schafmayer, Clemens, Hampe, Jochen, Subramanian, Pallavi

“…The rs641738C>T variant located near the membrane-bound O-acyltransferase domain containing 7 (MBOAT7) locus is associated with fibrosis in liver diseases,…”
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S1095 Association Between Fecal Calprotectin Cutoff Concentrations of 150 or 250 μg/g and Ozanimod Efficacy: A Post Hoc Analysis of the Phase 3 True North Study by Yarur, Andres, Dubinsky, Marla C., Ghosh, Subrata, Arsenescu, Razvan, Zeissig, Sebastian, Liu, Zhaohui, Harris, Sarah, Mehra, Dimpy, Jain, Anjali, Ananthakrishnan, Ashwin

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Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease by Petruo, Vanessa A, Zeißig, Sebastian, Schmelz, Renate, Hampe, Jochen, Beste, Christian

“…Inflammatory bowel disease (IBD) is highly prevalent. While the pathophysiological mechanisms of IBD are increasingly understood, there is a lack of knowledge…”
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Shotgun lipidomics-based characterization of the landscape of lipid metabolism in colorectal cancer by Wang, Yuting, Hinz, Sebastian, Uckermann, Ortrud, Hönscheid, Pia, von Schönfels, Witigo, Burmeister, Greta, Hendricks, Alexander, Ackerman, Jacobo Miranda, Baretton, Gustavo B., Hampe, Jochen, Brosch, Mario, Schafmayer, Clemens, Shevchenko, Andrej, Zeissig, Sebastian

“…Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma…”
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XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease by Kaser, Arthur, Lee, Ann-Hwee, Franke, Andre, Glickman, Jonathan N., Zeissig, Sebastian, Tilg, Herbert, Nieuwenhuis, Edward E.S., Higgins, Darren E., Schreiber, Stefan, Glimcher, Laurie H., Blumberg, Richard S.

“…Inflammatory bowel disease (IBD) has been attributed to aberrant mucosal immunity to the intestinal microbiota. The transcription factor XBP1, a key component…”
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Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure by Armacki, Milena, Trugenberger, Anna Katharina, Ellwanger, Ann K, Eiseler, Tim, Schwerdt, Christiane, Bettac, Lucas, Langgartner, Dominik, Azoitei, Ninel, Halbgebauer, Rebecca, Groß, Rüdiger, Barth, Tabea, Lechel, André, Walter, Benjamin M, Kraus, Johann M, Wiegreffe, Christoph, Grimm, Johannes, Scheffold, Annika, Schneider, Marlon R, Peuker, Kenneth, Zeißig, Sebastian, Britsch, Stefan, Rose-John, Stefan, Vettorazzi, Sabine, Wolf, Eckhart, Tannapfel, Andrea, Steinestel, Konrad, Reber, Stefan O, Walther, Paul, Kestler, Hans A, Radermacher, Peter, Barth, Thomas Fe, Huber-Lang, Markus, Kleger, Alexander, Seufferlein, Thomas

“…Dysregulated intestinal epithelial apoptosis initiates gut injury, alters the intestinal barrier, and can facilitate bacterial translocation leading to a…”
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Detecting drug resistance in pancreatic cancer organoids guides optimized chemotherapy treatment by Hennig, Alexander, Baenke, Franziska, Klimova, Anna, Drukewitz, Stephan, Jahnke, Beatrix, Brückmann, Sascha, Secci, Ramona, Winter, Christof, Schmäche, Tim, Seidlitz, Therese, Bereuter, Jean‐Paul, Polster, Heike, Eckhardt, Lisa, Schneider, Sidney A, Brückner, Stefan, Schmelz, Renate, Babatz, Jana, Kahlert, Christoph, Distler, Marius, Hampe, Jochen, Reichert, Maximilian, Zeißig, Sebastian, Folprecht, Gunnar, Weitz, Jürgen, Aust, Daniela, Welsch, Thilo, Stange, Daniel E

“…Drug combination therapies for cancer treatment show high efficacy but often induce severe side effects, resulting in dose or cycle number reduction. We…”
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Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control by Brosch, Mario, Kattler, Kathrin, Herrmann, Alexander, von Schönfels, Witigo, Nordström, Karl, Seehofer, Daniel, Damm, Georg, Becker, Thomas, Zeissig, Sebastian, Nehring, Sophie, Reichel, Fabian, Moser, Vincent, Thangapandi, Raghavan Veera, Stickel, Felix, Baretton, Gustavo, Röcken, Christoph, Muders, Michael, Matz-Soja, Madlen, Krawczak, Michael, Gasparoni, Gilles, Hartmann, Hella, Dahl, Andreas, Schafmayer, Clemens, Walter, Jörn, Hampe, Jochen

“…A deeper epigenomic understanding of spatial organization of cells in human tissues is an important challenge. Here we report the first combined positional…”
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Protective mucosal immunity mediated by epithelial CD1d and IL-10 by Olszak, Torsten, Neves, Joana F., Dowds, C. Marie, Baker, Kristi, Glickman, Jonathan, Davidson, Nicholas O., Lin, Chyuan-Sheng, Jobin, Christian, Brand, Stephan, Sotlar, Karl, Wada, Koichiro, Katayama, Kazufumi, Nakajima, Atsushi, Mizuguchi, Hiroyuki, Kawasaki, Kunito, Nagata, Kazuhiro, Müller, Werner, Snapper, Scott B., Schreiber, Stefan, Kaser, Arthur, Zeissig, Sebastian, Blumberg, Richard S.

“…Here, the presentation of lipid antigens by CD1d is shown to induce retrograde anti-inflammatory signalling in intestinal epithelial cells, resulting in the…”
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Epithelial Tight Junctions in Intestinal Inflammation by Schulzke, Joerg D., Ploeger, Svenja, Amasheh, Maren, Fromm, Anja, Zeissig, Sebastian, Troeger, Hanno, Richter, Jan, Bojarski, Christian, Schumann, Michael, Fromm, Michael

“…The epithelium in inflamed intestinal segments of patients with Crohn's disease is characterized by a reduction of tight junction strands, strand breaks, and…”
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Gastric Carcinomas with Stromal B7-H3 Expression Have Lower Intratumoural CD8+ T Cell Density by Ulase, Dita, Behrens, Hans-Michael, Krüger, Sandra, Zeissig, Sebastian, Röcken, Christoph

“…CD8+ T cells are the main effector cells of anti-cancer immune response that can be regulated by various costimulatory and coinhibitory molecules, including…”
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Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin by Melum, Espen, Jiang, Xiaojun, Baker, Kristi D., Macedo, M. Fatima, Fritsch, Jürgen, Dowds, C. Marie, Wang, Jing, Pharo, Anne, Kaser, Arthur, Tan, Corey, Pereira, Catia S., Kelly, Samuel L., Duan, Jingjing, Karlsen, Tom H., Exley, Mark A., Schütze, Stefan, Zajonc, Dirk M., Merrill, Alfred H., Schuchman, Edward H., Zeissig, Sebastian, Blumberg, Richard S.

“…Invariant natural killer T (iNKT) cells recognize activating self and microbial lipids presented by CD1d. CD1d can also bind non-activating lipids, such as…”
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TYK2 inhibition and its potential in the treatment of chronic inflammatory immune diseases by Ghoreschi, Kamran, Augustin, Matthias, Baraliakos, Xenofon, Krönke, Gerhard, Schneider, Matthias, Schreiber, Stefan, Schulze‐Koops, Hendrik, Zeißig, Sebastian, Thaçi, Diamant

“…Summary Immune‐mediated chronic inflammatory diseases have emerged as a leading cause of morbidity and mortality in Western countries over the last decades…”
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Subcutaneous infliximab in Crohn’s disease patients with previous immunogenic failure of intravenous infliximab by Husman, Julia, Černá, Karin, Matthes, Katja, Gilger, Maximilian, Arsova, Maia, Schmidt, Alexandra, Winzer, Nadia, Brosch, Anna-Magdalena, Brinkmann, Franz, Hampe, Jochen, Zeissig, Sebastian, Lukáš, Milan, Schmelz, Renate

“…Purpose Immunogenicity is a major reason for secondary loss of response to infliximab (IFX). Recent work suggested potentially lower immunogenicity of…”
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Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids by Rudolph, Maren, Wang, Yuting, Simolka, Theresa, Huc-Claustre, Emilie, Dai, Lingyun, Grotenbreg, Gijsbert, Besra, Gurdyal Singh, Shevchenko, Anna, Shevchenko, Andrej, Zeissig, Sebastian

“…CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of…”
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Stratifying esophago-gastric cancer treatment using a patient-derived organoid-based threshold by Schmäche, Tim, Fohgrub, Juliane, Klimova, Anna, Laaber, Karin, Drukewitz, Stephan, Merboth, Felix, Hennig, Alexander, Seidlitz, Therese, Herbst, Friederike, Baenke, Franziska, Ada, Anne-Marlen, Groß, Thomas, Wenzel, Carina, Ball, Claudia R, Praetorius, Christian, Schmidt, Thomas, Ringelband-Schilling, Barbara, Koschny, Ronald, Stenzinger, Albrecht, Roeder, Ingo, Jaeger, Dirk, Zeissig, Sebastian, Welsch, Thilo, Aust, Daniela, Glimm, Hanno, Folprecht, Gunnar, Weitz, Jürgen, Haag, Georg M, Stange, Daniel E

“…This study sought to determine the value of patient-derived organoids (PDOs) from esophago-gastric adenocarcinoma (EGC) for response prediction to neoadjuvant…”
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Disrupted Barrier Function through Epithelial Cell Apoptosis by SCHULZKE, JOERG-DIETER, BOJARSKI, CHRISTIAN, ZEISSIG, SEBASTIAN, HELLER, FRANK, GITTER, ALFRED H., FROMM, MICHAEL

“…:  Epithelial barrier function is determined by trans‐ and paracellular permeabilities, the latter of which is mainly influenced by tight junctions (TJs) and…”
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