Search Results - "Zehr, Elena"

Katanin Grips the β-Tubulin Tail through an Electropositive Double Spiral to Sever Microtubules by Zehr, Elena A., Szyk, Agnieszka, Szczesna, Ewa, Roll-Mecak, Antonina

“…The AAA ATPase katanin severs microtubules. It is critical in cell division, centriole biogenesis, and neuronal morphogenesis. Its mutation causes…”
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Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation by Vemu, Annapurna, Szczesna, Ewa, Zehr, Elena A, Spector, Jeffrey O, Grigorieff, Nikolaus, Deaconescu, Alexandra M, Roll-Mecak, Antonina

“…Spastin and katanin sever and destabilize microtubules. Paradoxically, despite their destructive activity they increase microtubule mass in vivo. We combined…”
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An allosteric network in spastin couples multiple activities required for microtubule severing by Sandate, Colby R., Szyk, Agnieszka, Zehr, Elena A., Lander, Gabriel C., Roll-Mecak, Antonina

“…The AAA+ ATPase spastin remodels microtubule arrays through severing and its mutation is the most common cause of hereditary spastic paraplegias (HSP)…”
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Microtubule-severing enzymes by Sarbanes, Stephanie L, Zehr, Elena A, Roll-Mecak, Antonina

“…Stephanie Sarbanes et al. discuss microtubule-severing enzymes, highlighting their shared structure and mechanism and the diversity of processes in which they…”
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Katanin spiral and ring structures shed light on power stroke for microtubule severing by Zehr, Elena, Szyk, Agnieszka, Piszczek, Grzegorz, Szczesna, Ewa, Zuo, Xiaobing, Roll-Mecak, Antonina

“…Using a combination of crystallography, SAXS and cryo-EM, the katanin hexamer is observed in spiral or ring arrangements, suggesting a mechanism to generate…”
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A look under the hood of the machine that makes cilia beat by Zehr, Elena A., Roll-Mecak, Antonina

“…The central apparatus regulates the beating of motile cilia. High-resolution structures of the almost complete central apparatus are now reported in two…”
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Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing by Szczesna, Ewa, Zehr, Elena A., Cummings, Steven W., Szyk, Agnieszka, Mahalingan, Kishore K., Li, Yan, Roll-Mecak, Antonina

“…Microtubules have spatiotemporally complex posttranslational modification patterns. How cells interpret this tubulin modification code is largely unknown. We…”
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A Phage Tubulin Assembles Dynamic Filaments by an Atypical Mechanism to Center Viral DNA within the Host Cell by Kraemer, James A., Erb, Marcella L., Waddling, Christopher A., Montabana, Elizabeth A., Zehr, Elena A., Wang, Hannah, Nguyen, Katrina, Pham, Duy Stephen L., Agard, David A., Pogliano, Joe

“…Tubulins are essential for the reproduction of many eukaryotic viruses, but historically, bacteriophage were assumed not to require a cytoskeleton. Here, we…”
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Structural basis for α-tubulin-specific and modification state-dependent glutamylation by Mahalingan, Kishore K., Grotjahn, Danielle A., Li, Yan, Lander, Gabriel C., Zehr, Elena A., Roll-Mecak, Antonina

“…Microtubules have spatiotemporally complex posttranslational modification patterns. Tubulin tyrosine ligase-like (TTLL) enzymes introduce the most prevalent…”
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Tubulin code eraser CCP5 binds branch glutamates by substrate deformation by Chen, Jiayi, Zehr, Elena A., Gruschus, James M., Szyk, Agnieszka, Liu, Yanjie, Tanner, Martin E., Tjandra, Nico, Roll-Mecak, Antonina

“…Microtubule function is modulated by the tubulin code, diverse posttranslational modifications that are altered dynamically by writer and eraser enzymes 1 …”
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Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae by Bertin, Aurélie, McMurray, Michael A, Pierson, Jason, Thai, Luong, McDonald, Kent L, Zehr, Elena A, García, 3rd, Galo, Peters, Peter, Thorner, Jeremy, Nogales, Eva

“…Septins are conserved GTP-binding proteins involved in membrane compartmentalization and remodeling. In budding yeast, five mitotic septins localize at the bud…”
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Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing by Sandate, Colby R., Szyk, Agnieszka, Zehr, Elena A., Lander, Gabriel C., Roll-Mecak, Antonina

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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The Structure and Assembly Mechanism of a Novel Three-Stranded Tubulin Filament that Centers Phage DNA by Zehr, Elena A., Kraemer, James A., Erb, Marcella L., Coker, Joanna K.C., Montabana, Elizabeth A., Pogliano, Joe, Agard, David A.

“…Tubulins are a universally conserved protein superfamily that carry out diverse biological roles by assembling filaments with very different architectures. The…”
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Katanin Spiral and Ring Structures Shed Light on Power Stroke for Microtubule Severing by Zehr, Elena A., Szyk, Agnieszka, Piszczek, Grzegorz, Szczesna, Ewa, Zuo, Xiaobing, Roll-Mecak, Antonina

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Severing Enzymes Amplify Microtubule Arrays through Lattice GTP-Tubulin Incorporation by Vemu, Annapurna, Szczesna, Ewa, Zehr, Elena A., Spector, Jeffrey O., Grigorieff, Nikolaus, Deaconescu, Alexandra M., Roll-Mecak, Antonina

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A phage tubulin assembles dynamic filaments by a novel mechanism to center viral DNA within the host cell by Kraemer, James A, Erb, Marcella L, Waddling, Christopher A, Montabana, Elizabeth A, Zehr, Elena A, Wang, Hannah, Nguyen, Katrina, Pham, Duy Stephen L, Agard, David A, Pogliano, Joe

“…Tubulins are essential for the reproduction of many eukaryotic viruses, but historically bacteriophage were assumed not to require a cytoskeleton. Here we…”
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Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae by Bertin, Aurélie, McMurray, Michael A., Pierson, Jason, Thai, Luong, McDonald, Kent L., Zehr, Elena A., García, Galo, Peters, Peter, Thorner, Jeremy, Nogales, Eva, Pollard, Thomas D.

“…Septins are conserved GTP-binding proteins involved in membrane compartmentalization and remodeling. In budding yeast, five mitotic septins localize at the bud…”
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The ultrastructure and nucleotide-regulated assembly mechanism of the bacteriophage-encoded tubulin homologue, PhuZ by Zehr, Elena A

“…Tubulin is a universally conserved molecule, found in all three domains of life. Tubulin filaments use energy derived from GTP binding and hydrolysis to…”
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