Search Results - "Zehner, Zendra E."

High-throughput miRNA sequencing and identification of biomarkers for forensically relevant biological fluids by Seashols-Williams, Sarah, Lewis, Carolyn, Calloway, Chelsea, Peace, Nerissa, Harrison, Ariana, Hayes-Nash, Christina, Fleming, Samantha, Wu, Qianni, Zehner, Zendra E.

“…microRNAs (miRNAs) are small noncoding RNAs that regulate cellular processes through modulation of proteins at the translational level. They tend to be highly…”
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Dual Action of miR-125b As a Tumor Suppressor and OncomiR-22 Promotes Prostate Cancer Tumorigenesis by Budd, William T, Seashols-Williams, Sarah J, Clark, Gene C, Weaver, Danielle, Calvert, Valerie, Petricoin, Emanuel, Dragoescu, Ema A, O'Hanlon, Katherine, Zehner, Zendra E

“…MicroRNAs (miRs) are a novel class of small RNA molecules, the dysregulation of which can contribute to cancer. A combinatorial approach was used to identify…”
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microRNA Detection in Blood, Urine, Semen, and Saliva Stains After Compromising Treatments by Layne, Tiffany R., Green, Raquel A., Lewis, Carolyn A., Nogales, Francy, Dawson Cruz, Tracey C., Zehner, Zendra E., Seashols‐Williams, Sarah J.

“…Evaluation of microRNA (miRNA) expression as a potential method for forensic body fluid identification has been the subject of investigation over the past…”
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Klf4, Klf2, and Zfp148 activate autophagy‐related genes in smooth muscle cells during aortic aneurysm formation by Salmon, Morgan, Spinosa, Michael, Zehner, Zendra E., Upchurch, Gilbert R., Ailawadi, Gorav

“…Abdominal aortic aneurysms (AAAs) are a progressive dilation of the aorta that is characterized by an initial influx of inflammatory cells followed by a…”
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Keratin down-regulation in vimentin-positive cancer cells is reversible by vimentin RNA interference, which inhibits growth and motility by Paccione, Rachel J, Miyazaki, Hiroshi, Patel, Vyomesh, Waseem, Ahmad, Gutkind, J Silvio, Zehner, Zendra E, Yeudall, W Andrew

“…At later stages of tumor progression, epithelial carcinogenesis is associated with transition to a mesenchymal phenotype, which may contribute to the more…”
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The zinc finger repressor, ZBP‐89, recruits histone deacetylase 1 to repress vimentin gene expression by Wu, Yongzhong, Zhang, Xueping, Salmon, Morgan, Zehner, Zendra E.

“…Vimentin, a member of the intermediate filament (IF) protein family, exhibits a complex pattern of tissue‐ and developmental‐specific expression. Although…”
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Isolation and Characterization of the Human tRNA-(N1G37) Methyltransferase (TRM5) and Comparison to the Escherichia coli TrmD Protein by Brulé, Hervé, Elliott, Mark, Redlak, Maria, Zehner, Zendra E, Holmes, W. Michael

“…A human TRM5 cDNA has been cloned and recombinant tRNA-N1G37 methyltransferase was produced. The recombinant enzyme methylates the N1 position of guanosine 37…”
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ZFP148 (Zinc-Finger Protein 148) Binds Cooperatively With NF-1 (Neurofibromin 1) to Inhibit Smooth Muscle Marker Gene Expression During Abdominal Aortic Aneurysm Formation by Salmon, Morgan, Schaheen, Basil, Spinosa, Michael, Montgomery, William, Pope, Nicolas H, Davis, John P, Johnston, William F, Sharma, Ashish K, Owens, Gary K, Merchant, Juanita L, Zehner, Zendra E, Upchurch, Gilbert R, Ailawadi, Gorav

“…OBJECTIVE—The goal of this study was to determine the role of ZFP148 (zinc-finger protein 148) in aneurysm formation. APPROACH AND RESULTS—ZFP148 mRNA…”
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TGFβ1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members by Wu, Yongzhong, Zhang, Xueping, Salmon, Morgan, Lin, Xia, Zehner, Zendra E.

“…Vimentin exhibits a complex pattern of developmental and tissue-specific expression regulated by such growth factors as TGFβ1, PDGF, FGF, EGF and cytokines…”
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MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection by Zhang, Xueping, Ladd, Amy, Dragoescu, Ema, Budd, William T, Ware, Joy L, Zehner, Zendra E

“…MicroRNAs (miRs) are a novel class of RNAs with important roles in regulating gene expression. To identify miRs controlling prostate tumor progression, we…”
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Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents by Zhang, Xueping, Haney, Kendra M., Richardson, Amanda C., Wilson, Eden, Gewirtz, David A., Ware, Joy L., Zehner, Zendra E., Zhang, Yan

“…Anibamine produces significant inhibition of prostate cancer cell proliferation at micromolar to submicromolar concentrations and inhibits prostate tumor…”
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Inhibition of vimentin or β1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo by Zhang, Xueping, Fournier, Marcia V., Ware, Joy L., Bissell, Mina J., Yacoub, Adly, Zehner, Zendra E.

“…Prostate epithelial cells grown embedded in laminin-rich extracellular matrix (lrECM) undergo morphologic changes that closely resemble their architecture in…”
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Over-expression of the transcription factor, ZBP-89, leads to enhancement of the C2C12 myogenic program by Salmon, Morgan, Owens, Gary K., Zehner, Zendra E.

“…Myogenesis involves the complex interplay between the down-regulation of non-muscle genes and the up-regulation of muscle-specific genes. This interplay is…”
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The transcriptional repressor ZBP-89 and the lack of Sp1/Sp3, c-Jun and Stat3 are important for the down-regulation of the vimentin gene during C2C12 myogenesis by Salmon, Morgan, Zehner, Zendra E.

“…Currently, considerable information is available about how muscle-specific genes are activated during myogenesis, yet little is known about how non-muscle…”
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microRNA Dysregulation in Prostate Cancer: Network Analysis Reveals Preferential Regulation of Highly Connected Nodes by Budd, William T., Weaver, Danielle E., Anderson, Joe, Zehner, Zendra E.

“…microRNAs (miRNAs) are small RNAs shown to contribute to a number of cellular processes including cell growth, differentiation, and apoptosis. MiRNAs regulate…”
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A networks method for ranking microRNA dysregulation in cancer by Budd, William T, Seashols, Sarah, Weaver, Danielle, Joseph, Cyriac, Zehner, Zendra E

“…Despite the lack of agreement on their exact roles, it is known that miRNAs contribute to cancer progression. Many studies utilize methods to detect…”
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c-Jun and the dominant-negative mutant, TAM67, induce vimentin gene expression by interacting with the activator Sp1 by Wu, Yongzhong, Zhang, Xueping, Zehner, Zendra E

“…Vimentin exhibits a complex pattern of developmental- and tissue-specific expression. Since it is aberrantly expressed in metastatic tumors, which have…”
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ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1 by Zhang, X, Diab, I.H, Zehner, Z.E

“…Vimentin, a member of the intermediate filament protein family, is regulated both developmentally and tissue specifically. It is also a marker of the…”
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Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89 by YONGZHONG WU, IMAN DIAB, XUEPING ZHANG, IZMAILOVA, Elena S, ZEHNER, Zendra E

“…Vimentin exhibits a complex pattern of developmental- and tissue-specific expression and is aberrantly expressed in most metastatic tumors. The human vimentin…”
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Proteomic analysis of the tumorigenic human prostate cell line M12 after microcell-mediated transfer of chromosome 19 demonstrates reduction of vimentin by Liu, Xuhui, Wu, Yongzhong, Zehner, Zendra E., Jackson-Cook, Colleen, Ware, Joy L.

“…Critical alterations in proteins that accompany or control the aggressiveness of human prostate cancers remain poorly defined. Previously we demonstrated that…”
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