Search Results - "Zeev, A"

Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection by Kuang, Ersheng, Okumura, Cheryl Y M, Sheffy-Levin, Sharon, Varsano, Tal, Shu, Vincent Chih-Wen, Qi, Jianfei, Niesman, Ingrid R, Yang, Huei-Jiun, López-Otín, Carlos, Yang, Wei Yuan, Reed, John C, Broday, Limor, Nizet, Victor, Ronai, Ze'ev A

“…Autophagy is the mechanism by which cytoplasmic components and organelles are degraded by the lysosomal machinery in response to diverse stimuli including…”
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UPR, autophagy, and mitochondria crosstalk underlies the ER stress response by Senft, Daniela, Ronai, Ze’ev A.

“…•Autophagy and UPR interaction underlies ERS response outcomes.•ERS modulates mitochondrial biogenesis and function.•Ubiquitin ligases fine-tune the ERS…”
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Fine tuning of the UPR by the ubiquitin ligases Siah1/2 by Scortegagna, Marzia, Kim, Hyungsoo, Li, Jian-Liang, Yao, Hang, Brill, Laurence M, Han, Jaeseok, Lau, Eric, Bowtell, David, Haddad, Gabriel, Kaufman, Randal J, Ronai, Ze'ev A

“…The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). Yet, it is not known…”
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Injuries among talented young dancers: findings from the U.K. Centres for Advanced Training by Steinberg, N, Aujla, I, Zeev, A, Redding, E

“…The aim of the present study was to characterize the injuries of young dancers attending Centres for Advanced Training. 806 dancers, ages 10-18 years responded…”
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Ubiquitin ligases in oncogenic transformation and cancer therapy by Senft, Daniela, Qi, Jianfei, Ronai, Ze'ev A.

“…Key Points Ubiquitin ligases (E3s) are deregulated in cancer through diverse mechanisms, resulting in altered expression and/or activity of their target…”
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The association between hallux valgus and proximal joint alignment in young female dancers by Steinberg, N, Siev-Ner, I, Zeev, A, Dar, G

“…Very little is known about the relationship between proximal joint alignment and hallux valgus among young dancers. This study sought to determine the extent…”
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Regulators of mitochondrial dynamics in cancer by Senft, Daniela, Ronai, Ze’ev A

“…Graphical abstract…”
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PRMT5 function and targeting in cancer by Kim, Hyungsoo, Ronai, Ze'ev A

“…Protein methyl transferases play critical roles in numerous regulatory pathways that underlie cancer development, progression and therapy-response. Here we…”
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Precision Oncology: The Road Ahead by Senft, Daniela, Leiserson, Mark D.M., Ruppin, Eytan, Ronai, Ze’ev A.

“…Current efforts in precision oncology largely focus on the benefit of genomics-guided therapy. Yet, advances in sequencing techniques provide an unprecedented…”
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The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion by Scortegagna, Marzia, Berthon, Annabel, Settas, Nikolaos, Giannakou, Andreas, Garcia, Guillermina, Li, Jian-Liang, James, Brian, Liddington, Robert C, Vilches-Moure, José G, Stratakis, Constantine A, Ronai, Ze'ev A

“…Primary and secondary hypertension are major risk factors for cardiovascular disease, the leading cause of death worldwide. Elevated secretion of aldosterone…”
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MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction by Pathria, Gaurav, Verma, Sachin, Yin, Jun, Scott, David A, Ronai, Ze’ev A

“…Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to…”
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ATF2, a paradigm of the multifaceted regulation of transcription factors in biology and disease by Watson, Gregory, Ronai, Ze’ev A., Lau, Eric

“…[Display omitted] Stringent transcriptional regulation is crucial for normal cellular biology and organismal development. Perturbations in the proper…”
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Lipid metabolism: new twists to the Yin and Yang of PKM2 in cancer by Khateb, Ali, Ronai, Ze’ev A

“…While canonical and non‐canonical functions of pyruvate kinase M2 (PKM2) are recognized to mediate often‐opposing roles in cancer, its contribution to cellular…”
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Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia by Kim, Hyungsoo, Scimia, Maria C., Wilkinson, Deepti, Trelles, Ramon D., Wood, Malcolm R., Bowtell, David, Dillin, Andrew, Mercola, Mark, Ronai, Ze'ev A.

“…Defining the mechanisms underlying the control of mitochondrial fusion and fission is critical to understanding cellular adaptation to diverse physiological…”
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Translational reprogramming marks adaptation to asparagine restriction in cancer by Pathria, Gaurav, Lee, Joo Sang, Hasnis, Erez, Tandoc, Kristofferson, Scott, David A., Verma, Sachin, Feng, Yongmei, Larue, Lionel, Sahu, Avinash D., Topisirovic, Ivan, Ruppin, Eytan, Ronai, Ze’ev A.

“…While amino acid restriction remains an attractive strategy for cancer therapy, metabolic adaptations limit its effectiveness. Here we demonstrate a role of…”
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An exploitable Achilles heel of MITF? by Silva, Carolina, Ronai, Ze’ev A.

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The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors by Khateb, Ali, Deshpande, Anagha, Feng, Yongmei, Finlay, Darren, Lee, Joo Sang, Lazar, Ikrame, Fabre, Bertrand, Li, Yan, Fujita, Yu, Zhang, Tongwu, Yin, Jun, Pass, Ian, Livneh, Ido, Jeremias, Irmela, Burian, Carol, Mason, James R., Almog, Ronit, Horesh, Nurit, Ofran, Yishai, Brown, Kevin, Vuori, Kristiina, Jackson, Michael, Ruppin, Eytan, Deshpande, Aniruddha J., Ronai, Ze’ev A.

“…Acute myeloid leukemia (AML) remains incurable, largely due to its resistance to conventional treatments. Here, we find that increased abundance of the…”
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Joint range of motion and patellofemoral pain in dancers by Steinberg, N, Siev-Ner, I, Peleg, S, Dar, G, Masharawi, Y, Zeev, A, Hershkovitz, I

“…The aim of the present study was to determine the association between joint range of motion (ROM) and patellofemoral pain syndrome (PFPS) in young female…”
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Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor by Kim, Hyungsoo, Ronai, Ze’ev A.

“…Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as…”
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Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons by Welsbie, Derek S., Mitchell, Katherine L., Jaskula-Ranga, Vinod, Sluch, Valentin M., Yang, Zhiyong, Kim, Jessica, Buehler, Eugen, Patel, Amit, Martin, Scott E., Zhang, Ping-Wu, Ge, Yan, Duan, Yukan, Fuller, John, Kim, Byung-Jin, Hamed, Eman, Chamling, Xitiz, Lei, Lei, Fraser, Iain D.C., Ronai, Ze’ev A., Berlinicke, Cynthia A., Zack, Donald J.

“…Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To…”
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