Search Results - "Zeeuwen, P.L.J.M."

Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair by de Koning, H.D., van den Bogaard, E.H., Bergboer, J.G.M., Kamsteeg, M., van Vlijmen-Willems, I.M.J.J., Hitomi, K., Henry, J., Simon, M., Takashita, N., Ishida-Yamamoto, A., Schalkwijk, J., Zeeuwen, P.L.J.M.

“…Summary Background  Recent studies have emphasized the importance of heritable and acquired skin barrier abnormalities in common inflammatory diseases such as…”
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The cystatin M / E-controlled pathway of skin barrier formation: expression of its key components in psoriasis and atopic dermatitis by Cheng, T., Tjabringa, G.S., Van Vlijmen-Willems, I.M.J.J., Hitomi, K., Van Erp, P.E.J., Schalkwijk, J., Zeeuwen, P.L.J.M.

“…Summary Background  The antiprotease activity of cystatin M/E regulates skin barrier formation, as it inhibits the activity of cathepsin V, cathepsin L and…”
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CD26/dipeptidyl-peptidase IV in psoriatic skin: upregulation and topographical changes by Van Lingen, R.G., Van De Kerkhof, P.C.M., Seyger, M.M.B., De Jong, E.M.G.J., Van Rens, D.W.A., Poll, M.K.P., Zeeuwen, P.L.J.M., Van Erp, P.E.J.

“…Summary Background  Psoriasis is known to affect 2–3% of the population and can be considered an organ‐specific autoimmune disease. CD26/dipeptidyl‐peptidase…”
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Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis by Reek, J.M.P.A., Coenen, M.J.H., L'Isle Arias, M., Zweegers, J., Rodijk‐Olthuis, D., Schalkwijk, J., Vermeulen, S.H., Joosten, I., Kerkhof, P.C.M., Seyger, M.M.B., Zeeuwen, P.L.J.M., Jong, E.M.G.J.

“…Summary Background The effectiveness of biologics for psoriasis shows heterogeneity among patients. With pharmacogenetic markers, it might be possible to…”
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Mast-cell interleukin-1β, neutrophil interleukin-17 and epidermal antimicrobial proteins in the neutrophilic urticarial dermatosis in Schnitzler's syndrome by de Koning, H.D., van Vlijmen-Willems, I.M.J.J., Rodijk-Olthuis, D., van der Meer, J.W.M., Zeeuwen, P.L.J.M., Simon, A., Schalkwijk, J.

“…Summary Background Schnitzler's syndrome (SchS) is an autoinflammatory disease characterized by a chronic urticarial rash, a monoclonal component and signs of…”
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Late cornified envelope (LCE) proteins: distinct expression patterns of LCE2 and LCE3 members suggest nonredundant roles in human epidermis and other epithelia by Niehues, H., van Vlijmen-Willems, I.M.J.J., Bergboer, J.G.M., Kersten, F.F.J., Narita, M., Hendriks, W.J.A.J., van den Bogaard, E.H., Zeeuwen, P.L.J.M., Schalkwijk, J.

“…Summary Background Deletion of the late cornified envelope (LCE) proteins LCE3B and LCE3C is a strong and widely replicated psoriasis risk factor. It is…”
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Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis by Kamsteeg, M., Jansen, P.A.M., Van Vlijmen-Willems, I.M.J.J., Van Erp, P.E.J., Rodijk-Olthuis, D., Van Der Valk, P.G., Feuth, T., Zeeuwen, P.L.J.M., Schalkwijk, J.

“…Summary Background  Microarray studies on the epidermal transcriptome in psoriasis and atopic dermatitis (AD) have revealed genes with disease‐specific…”
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Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C06 by Bergboer, J.G.M., Oostveen, A.M., de Jager, M.E.A., den Heijer, M., Joosten, I., van de Kerkhof, P.C.M., Zeeuwen, P.L.J.M., de Jong, E.M.G.J., Schalkwijk, J., Seyger, M.M.B.

“…Summary Background  Recent genome‐wide association studies have identified several genetic risk factors for psoriasis, but data on their association with age…”
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The effect of adalimumab on key drivers in the pathogenesis of psoriasis by Hendriks, A.G.M., van der Velden, H.M.J., Wolberink, E.A.W., Seyger, M.M.B., Schalkwijk, J., Zeeuwen, P.L.J.M., de Jong, E.M.G.J., Pasch, M.C., van Erp, P.E.J., van de Kerkhof, P.C.M.

“…Summary Background The use of recently introduced biologics targeting specific immune mechanisms has identified crucial steps in the pathogenesis of psoriasis…”
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Keratolysis exfoliativa (dyshidrosis lamellosa sicca): a distinct peeling entity: Keratolysis exfoliativa by Chang, Y.Y., van der Velden, J., van der Wier, G., Kramer, D., Diercks, G.F.H., van Geel, M., Coenraads, P.J., Zeeuwen, P.L.J.M., Jonkman, M.F.

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Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C06: Genetics in paediatric-onset psoriasis by Bergboer, J.G.M., Oostveen, A.M., de Jager, M.E.A., den Heijer, M., Joosten, I., van de Kerkhof, P.C.M., Zeeuwen, P.L.J.M., de Jong, E.M.G.J., Schalkwijk, J., Seyger, M.M.B.

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Keratolysis exfoliativa (dyshidrosis lamellosa sicca): a distinct peeling entity by Chang, Y.Y., van der Velden, J., van der Wier, G., Kramer, D., Diercks, G.F.H., van Geel, M., Coenraads, P.J., Zeeuwen, P.L.J.M., Jonkman, M.F.

“…Summary Background  Keratolysis exfoliativa (KE), also known as dyshidrosis lamellosa sicca, is a palmoplantar dermatosis characterized by air‐filled blisters…”
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Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair: Structural protein expression upon artificial barrier disruption by de Koning, H.D., van den Bogaard, E.H., Bergboer, J.G.M., Kamsteeg, M., van Vlijmen-Willems, I.M.J.J., Hitomi, K., Henry, J., Simon, M., Takashita, N., Ishida-Yamamoto, A., Schalkwijk, J., Zeeuwen, P.L.J.M.

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Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis: Molecular diagnostics of skin diseases by Kamsteeg, M., Jansen, P.A.M., Van Vlijmen-Willems, I.M.J.J., Van Erp, P.E.J., Rodijk-Olthuis, D., Van Der Valk, P.G., Feuth, T., Zeeuwen, P.L.J.M., Schalkwijk, J.

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Induction of SLPI (ALP/HUSI-I) in Epidermal Keratinocytes by Wingens, Miriam, van Bergen, Bert H., van Vlijmen-Willems, Ivonne M.J.J., Zeeuwen, Patrick L.J.M., van Ruissen, Fred, Schalkwijk, Joost, Hiemstra, Pieter S., Meis, Jacques F.G.M., Mulder, Janet, Kramps, Hans A.

“…Secretory leukocyte protease inhibitor (SLPI) is a small, cationic protein that is known to be constitutively expressed by several glandular epithelia. SLPI…”
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Cystatin M / E expression in inflammatory and neoplastic skin disorders by Zeeuwen, P.L.J.M., Van Vlijmen-Willems, I.M.J.J., Egami, H., Schalkwijk, J.

“…Summary Background Cystatins are natural and specific inhibitors of endogenous mammalian lysosomal cysteine proteinases and exogenous microbial cysteine…”
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Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13 by Molhuizen, H O, Zeeuwen, P L, Olde Weghuis, D, Geurts van Kessel, A, Schalkwijk, J

“…Recently we isolated a cDNA clone corresponding to an epidermal serine proteinase inhibitor named SKALP (skin-derived antileukoproteinase). Here we report the…”
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