Search Results - "Zeef, Leo A H."

Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation by Minogue, Ben M., Richardson, Stephen M., Zeef, Leo A. H., Freemont, Anthony J., Hoyland, Judith A.

“…Objective Development of stem cell therapies for regenerating the nucleus pulposus (NP) are hindered by the lack of specific markers by which to distinguish NP…”
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Regulation of the BMP Signaling-Responsive Transcriptional Network in the Drosophila Embryo by Deignan, Lisa, Pinheiro, Marco T, Sutcliffe, Catherine, Saunders, Abbie, Wilcockson, Scott G, Zeef, Leo A H, Donaldson, Ian J, Ashe, Hilary L

“…The BMP signaling pathway has a conserved role in dorsal-ventral axis patterning during embryonic development. In Drosophila, graded BMP signaling is…”
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Experimental long-term diabetes mellitus alters the transcriptome and biomechanical properties of the rat urinary bladder by Hindi, Emad A., Williams, Craig J., Zeef, Leo A. H., Lopes, Filipa M., Newman, Katie, Davey, Martha M. M., Hodson, Nigel W., Hilton, Emma N., Huang, Jennifer L., Price, Karen L., Roberts, Neil A., Long, David A., Woolf, Adrian S., Gardiner, Natalie J.

“…Diabetes mellitus (DM) is the leading cause of chronic kidney disease and diabetic nephropathy is widely studied. In contrast, the pathobiology of diabetic…”
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Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells by Vascotto, Carlo, Cesaratto, Laura, Zeef, Leo A.H, Deganuto, Marta, D'Ambrosio, Chiara, Scaloni, Andrea, Romanello, Milena, Damante, Giuseppe, Taglialatela, Giulio, Delneri, Daniela, Kelley, Mark R, Mitra, Sankar, Quadrifoglio, Franco, Tell, Gianluca

“…Apurinic apyrimidinic endonuclease/redox effector factor 1 (APE1/Ref-1) protects cells from oxidative stress by acting as a central enzyme in base excision…”
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Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome by Kasher, Paul R, Jenkinson, Emma M, Briolat, Valérie, Gent, David, Morrissey, Catherine, Zeef, Leo A H, Rice, Gillian I, Levraud, Jean-Pierre, Crow, Yanick J

“…In humans, loss of function mutations in the SAMHD1 (AGS5) gene cause a severe form of Aicardi-Goutières syndrome (AGS), an inherited inflammatory-mediated…”
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WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line by Goodfellow, Sarah J, Rebello, Michelle R, Toska, Eneda, Zeef, Leo A H, Rudd, Sean G, Medler, Kathryn F, Roberts, Stefan G E

“…The Wilms' tumour suppressor WT1 (Wilms' tumour 1) is a transcriptional regulator that plays a central role in organogenesis, and is mutated or aberrantly…”
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Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature by Crow, Yanick J, Briggs, Tracy A, Rice, Gillian I, Daly, Sarah, Urquhart, Jill, Gornall, Hannah, Bader-Meunier, Brigitte, Baskar, Kannan, Baskar, Shankar, Baudouin, Veronique, Beresford, Michael W, Black, Graeme C M, Dearman, Rebecca J, de Zegher, Francis, Foster, Emily S, Francès, Camille, Hayman, Alison R, Hilton, Emma, Job-Deslandre, Chantal, Kulkarni, Muralidhar L, Le Merrer, Martine, Linglart, Agnes, Lovell, Simon C, Maurer, Kathrin, Musset, Lucile, Navarro, Vincent, Picard, Capucine, Puel, Anne, Rieux-Laucat, Frederic, Roifman, Chaim M, Scholl-Bürgi, Sabine, Smith, Nigel, Szynkiewicz, Marcin, Wiedeman, Alice, Wouters, Carine, Zeef, Leo A H, Casanova, Jean-Laurent, Elkon, Keith B, Janckila, Anthony, Lebon, Pierre

“…We studied ten individuals from eight families showing features consistent with the immuno-osseous dysplasia spondyloenchondrodysplasia. Of particular note was…”
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Transcriptional response of Pseudomonas aeruginosa to a phosphate-deficient Lolium perenne rhizosphere by Zyśko, Agnieszka, Sanguin, Hervé, Hayes, Andrew, Wardleworth, Leanne, Zeef, Leo A. H., Sim, Allan, Paterson, Eric, Singh, Brajesh K., Kertesz, Michael A.

“…Background and aims Plant-bacterial interactions in the rhizosphere are important in mediating soil nutrient transformations. Plants supply carbon-rich…”
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Ternary Complex Factor-Serum Response Factor Complex-Regulated Gene Activity Is Required for Cellular Proliferation and Inhibition of Apoptotic Cell Death by Vickers, Elaine R., Kasza, Aneta, Kurnaz, Isil Aksan, Seifert, Anne, Zeef, Leo A. H., O'Donnell, Amanda, Hayes, Andy, Sharrocks, Andrew D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of Novel Genes in Arabidopsis Involved in Secondary Cell Wall Formation Using Expression Profiling and Reverse Genetics by Brown, David M, Zeef, Leo A.H, Ellis, Joanne, Goodacre, Royston, Turner, Simon R

“…Forward genetic screens have led to the isolation of several genes involved in secondary cell wall formation. A variety of evidence, however, suggests that the…”
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Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1 by Mukherjee, Debayan, Romano, Erminia, Walshaw, Richard, Zeef, Leo A. H., Banyard, Antonia, Kitcatt, Stephen J., Cheadle, Eleanor J., Tuomela, Karoliina, Pendharkar, Swati, Al-Deka, Aws, Salerno, Beatrice, Raby, Sophie, Mills, Ian G., Honeychurch, Jamie, Illidge, Tim M.

“…Despite breakthroughs in immune checkpoint inhibitors (ICI), the majority of tumors, including those poorly infiltrated by CD8+ T cells or heavily infiltrated…”
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Glucose depletion inhibits translation initiation via eIF4A loss and subsequent 48S preinitiation complex accumulation, while the pentose phosphate pathway is coordinately up-regulated by Castelli, Lydia M, Lui, Jennifer, Campbell, Susan G, Rowe, William, Zeef, Leo A H, Holmes, Leah E A, Hoyle, Nathaniel P, Bone, Jonathon, Selley, Julian N, Sims, Paul F G, Ashe, Mark P

“…Cellular stress can globally inhibit translation initiation, and glucose removal from yeast causes one of the most dramatic effects in terms of rapidity and…”
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Mutations in PRDM5 in Brittle Cornea Syndrome Identify a Pathway Regulating Extracellular Matrix Development and Maintenance by BURKITT WRIGHT, Emma M. M, SPENCER, Helen L, MADDEN, Colm, DODDS, Annabel, CHANDLER, Kate E, BANKA, Siddharth, AU, Leon, CLAYTON-SMITH, Jill, KHAN, Naz, BIESECKER, Leslie G, WILSON, Meredith, ROHRBACH, Marianne, DALY, Sarah B, COLOMBI, Marina, GIUNTA, Cecilia, BLACK, Graeme C. M, MANSON, Forbes D. C, ZEEF, Leo A. H, URQUHART, Jill, ZOPPI, Nicoletta, BONSHEK, Richard, TOSOUNIDIS, Ioannis, MOHAN, Meyyammai

“…Extreme corneal fragility and thinning, which have a high risk of catastrophic spontaneous rupture, are the cardinal features of brittle cornea syndrome (BCS),…”
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Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function by Vascotto, Carlo, Bisetto, Elena, Li, Mengxia, Zeef, Leo A H, D'Ambrosio, Chiara, Domenis, Rossana, Comelli, Marina, Delneri, Daniela, Scaloni, Andrea, Altieri, Fabio, Mavelli, Irene, Quadrifoglio, Franco, Kelley, Mark R, Tell, Gianluca

“…Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1) protects cells from oxidative stress via the base excision repair pathway and as a redox…”
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Functional molecules in mesothelial‐to‐mesenchymal transition revealed by transcriptome analyses by Namvar, Sara, Woolf, Adrian S, Zeef, Leo AH, Wilm, Thomas, Wilm, Bettina, Herrick, Sarah E

“…Peritoneal fibrosis is a common complication of abdominal and pelvic surgery, and can also be triggered by peritoneal dialysis, resulting in treatment failure…”
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The Forkhead Transcription Factor FOXK2 Promotes AP-1-Mediated Transcriptional Regulation by Ji, Zongling, Donaldson, Ian J., Liu, Jingru, Hayes, Andrew, Zeef, Leo A. H., Sharrocks, Andrew D.

“…OA  Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1 by McCaffrey, James C., Webb, Nicholas J., Poolman, Toryn M., Fresquet, Maryline, Moxey, Cressida, Zeef, Leo A. H., Donaldson, Ian J., Ray, David W., Lennon, Rachel

“…Nephrotic syndrome (NS) occurs when the glomerular filtration barrier becomes excessively permeable leading to massive proteinuria. In childhood NS, immune…”
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Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell by D'Elia, Riccardo, DeSchoolmeester, Matthew L, Zeef, Leo A H, Wright, Steven H, Pemberton, Alan D, Else, Kathryn J

“…Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have…”
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Chick tendon fibroblast transcriptome and shape depend on whether the cell has made its own collagen matrix by Yeung, Ching-Yan Chloé, Zeef, Leo A. H., Lallyett, Chloe, Lu, Yinhui, Canty-Laird, Elizabeth G., Kadler, Karl E.

“…Collagen- and fibrin-based gels are extensively used to study cell behaviour. However, 2D–3D and collagen-fibrin comparisons of gene expression, cell shape and…”
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Overactivity or blockade of transforming growth factor‐β each generate a specific ureter malformation by Lopes, Filipa M, Roberts, Neil A, Zeef, Leo AH, Gardiner, Natalie J, Woolf, Adrian S

“…Transforming growth factor‐β (TGFβ) has been reported to be dysregulated in malformed ureters. There exists, however, little information on whether altered…”
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