Search Results - "Zeeb, Fiona D"

Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task by ZEEB, Fiona D, ROBBINS, Trevor W, WINSTANLEY, Catharine A

“…Pathological gambling (PG) is characterized by persistent, maladaptive gambling behavior, which disrupts personal and professional life. Animal models of…”
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Functional disconnection of the orbitofrontal cortex and basolateral amygdala impairs acquisition of a rat gambling task and disrupts animals' ability to alter decision-making behavior after reinforcer devaluation by Zeeb, Fiona D, Winstanley, Catharine A

“…An inability to adjust choice preferences in response to changes in reward value may underlie key symptoms of many psychiatric disorders, including chemical…”
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Lesions of the basolateral amygdala and orbitofrontal cortex differentially affect acquisition and performance of a rodent gambling task by Zeeb, Fiona D, Winstanley, Catharine A

“…Risky decision making on the Iowa Gambling Task (IGT) has been observed in several psychiatric disorders, including substance abuse, schizophrenia, and…”
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Inactivation of the prelimbic or infralimbic cortex impairs decision-making in the rat gambling task by Zeeb, Fiona D., Baarendse, P. J. J., Vanderschuren, L. J. M. J., Winstanley, Catharine A.

“…Rationale Studies employing the Iowa Gambling Task (IGT) demonstrated that areas of the frontal cortex, including the ventromedial prefrontal cortex,…”
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Dissociable effects of systemic and orbitofrontal administration of adrenoceptor antagonists on yohimbine-induced motor impulsivity by Adams, Wendy K., Barrus, Michael M., Zeeb, Fiona D., Cocker, Paul J., Benoit, James, Winstanley, Catharine A.

“…The α2-adrenoceptor antagonist, yohimbine, is commonly used as a pharmacological stressor. Its behavioural effects are typically attributed to elevated…”
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Disadvantageous decision-making on a rodent gambling task is associated with increased motor impulsivity in a population of male rats by Barrus, Michael M., BA, Hosking, Jay G., PhD, Zeeb, Fiona D., PhD, Tremblay, Melanie, MA, Winstanley, Catharine A., PhD

“…Background Impulsivity is understood as a range of behaviours, but the association between these behaviours is not well understood. Although high motor…”
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Dopaminergic modulation of the orbitofrontal cortex affects attention, motivation and impulsive responding in rats performing the five-choice serial reaction time task by Winstanley, Catharine A., Zeeb, Fiona D., Bedard, Amanda, Fu, Kent, Lai, Barbara, Steele, Christina, Wong, Adeline C.

“…Understanding the neurobiological factors underlying individual differences in impulsivity may provide valuable insight into vulnerability to impulse control…”
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Yohimbine Increases Impulsivity Through Activation of cAMP Response Element Binding in the Orbitofrontal Cortex by Sun, HaoSheng, Green, Thomas A, Theobald, David E.H, Birnbaum, Shari G, Graham, Danielle L, Zeeb, Fiona D, Nestler, Eric J, Winstanley, Catharine A

“…Background Stress can increase impulsivity and has a negative impact on psychiatric outcome. Norepinephrine is heavily implicated in responses to stress, and…”
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Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues by Zeeb, Fiona D., Floresco, Stan B., Winstanley, Catharine A.

“…Rationale Individual differences in impulsive decision-making may be critical determinants of vulnerability to impulse control disorders and substance abuse,…”
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Differential effects of environmental enrichment, social-housing, and isolation-rearing on a rat gambling task: Dissociations between impulsive action and risky decision-making by Zeeb, Fiona D., Wong, Adeline C., Winstanley, Catharine A.

“…Rationale Decision-making deficits, measured using the Iowa Gambling Task (IGT), are observed in many psychiatric populations. Additionally, evidence suggests…”
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Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex by Sun, HaoSheng, Cocker, Paul J., Zeeb, Fiona D., Winstanley, Catharine A.

“…Rationale Impulsivity is a key symptom of attention-deficit hyperactivity disorder (ADHD). The use of the norepinephrine reuptake inhibitor, atomoxetine, to…”
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Enhanced attention and impulsive action following NMDA receptor GluN2B-selective antagonist pretreatment by Higgins, Guy A., Silenieks, Leo B., MacMillan, Cam, Sevo, Julia, Zeeb, Fiona D., Thevarkunnel, Sandy

“…•NMDA GluN2B antagonists traxoprodil and Ro 63–1908 improve measures of attention in 5-CSRTT.•Traxoprodil and Ro 63–1908 increase measures of impulsive and…”
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Low Impulsive Action, but not Impulsive Choice, Predicts Greater Conditioned Reinforcer Salience and Augmented Nucleus Accumbens Dopamine Release by Zeeb, Fiona D, Soko, Ashlie D, Ji, Xiaodong, Fletcher, Paul J

“…Poor impulse control is associated with an increased propensity to develop an addiction and may contribute to relapse as high impulsive subjects appear to…”
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Role of impulsivity and reward in the anti-obesity actions of 5-HT2C receptor agonists by Higgins, Guy A, Zeeb, Fiona D, Fletcher, Paul J

“…The selective 5-HT2C receptor agonist lorcaserin entered clinical obesity trials with the prevalent view that satiety was a primary mechanism of action…”
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Differential effects of lipopolysaccharide on cognition, corticosterone and cytokines in socially-housed vs isolated male rats by Russell, Brittney, Hrelja, Kelly M., Adams, Wendy K., Zeeb, Fiona D., Taves, Matthew D., Kaur, Sukhbir, Soma, Kiran K., Winstanley, Catharine A.

“…Social isolation is an established risk factor for mental illness and impaired immune function. Evidence suggests that neuroinflammatory processes contribute…”
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Uncertainty exposure causes behavioural sensitization and increases risky decision-making in male rats: toward modelling gambling disorder by Zeeb, Fiona D, Li, Zhaoxia, Fisher, Daniel C, Zack, Martin H, Fletcher, Paul J

“…An animal model of gambling disorder, previously known as pathological gambling, could advance our understanding of the disorder and help with treatment…”
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Effects of exposure to chronic uncertainty and a sensitizing regimen of amphetamine injections on locomotion, decision-making, and dopamine receptors in rats by Fugariu, Victoria, Zack, Martin H, Nobrega, José N, Fletcher, Paul J, Zeeb, Fiona D

“…Gambling disorder (GD) is a behavioral addiction that may be linked to alterations in dopamine (DA) systems. Gambling involves chronic exposure to uncertain…”
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Effects of the NMDA receptor antagonists dizocilpine and Ro 63-1908 on delay-discounting and risky decision-making in a gambling task by Higgins, Guy A., Silenieks, Leo B., MacMillan, Cam, Zeeb, Fiona D., Thevarkunnel, Sandy

“…•Dizocilpine effect on delay discounting dependent on delay order.•Effect most consistent with behavioural inflexibility rather than impulsive…”
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Responding for a conditioned reinforcer or unconditioned sensory reinforcer in mice: interactions with environmental enrichment, social isolation, and monoamine reuptake inhibitors by Browne, Caleb J., Fletcher, Paul J., Zeeb, Fiona D.

“…Rationale Environmental factors influence the etiology of many psychiatric disorders. Likewise, environmental factors can alter processes central to…”
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Effects of 5-HT1A, 5-HT2A and 5-HT2C receptor agonists and antagonists on responding for a conditioned reinforcer and its enhancement by methylphenidate by Fletcher, Paul J., Zeeb, Fiona D., Browne, Caleb J., Higgins, Guy A., Soko, Ashlie D.

“…Objectives These experiments examined the effects of selective 5-HT 1A , 5-HT 2A and 5-HT 2C receptor ligands on responding for a conditioned reinforcer (CRf)…”
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