Search Results - "Zee, Catharina E.E.M. Van der"
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Mice lacking brain-type creatine kinase activity show defective thermoregulation
Published in Physiology & behavior (20-04-2009)“…Abstract The cytosolic brain-type creatine kinase and mitochondrial ubiquitous creatine kinase (CK-B and UbCKmit) are expressed during the prepubescent and…”
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2
Flow of energy in the outer retina in darkness and in light
Published in Proceedings of the National Academy of Sciences - PNAS (11-05-2010)“…Structural features of neurons create challenges for effective production and distribution of essential metabolic energy. We investigated how metabolic energy…”
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3
Hair Bundles Are Specialized for ATP Delivery via Creatine Kinase
Published in Neuron (Cambridge, Mass.) (01-02-2007)“…When stimulated strongly, a hair cell's mechanically sensitive hair bundle may consume ATP too rapidly for replenishment by diffusion. To provide a broad view…”
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4
Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation
Published in European journal of pharmacology (05-11-2013)“…The neural substrate of adaptive thermoregulation in mice lacking both brain-type creatine kinase isoforms is further investigated. The cytosolic brain-type…”
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Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice
Published in Behavioural brain research (17-03-2010)“…The 9q34.3 subtelomeric deletion syndrome is a newly defined mental retardation syndrome, caused by haplo-insufficiency of the euchromatin histone…”
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Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels
Published in Neurobiology of disease (01-10-2010)“…Abstract Enoxaparin (Enox), a low molecular weight heparin, has been shown to lower brain amyloid β (Aβ) load in a mouse model for Alzheimer's disease…”
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The DMWD protein from the myotonic dystrophy (DM1) gene region is developmentally regulated and is present most prominently in synapse-dense brain areas
Published in Brain research (02-05-2003)“…The DMWD gene is located in the myotonic dystrophy (DM1) gene cluster on 19q, just upstream of the DMPK gene. RNA and protein products of this gene are…”
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Mice lacking leukocyte common antigen-related (LAR) protein tyrosine phosphatase domains demonstrate spatial learning impairment in the two-trial water maze and hyperactivity in multiple behavioural tests
Published in Behavioural brain research (23-09-2004)“…Leukocyte common antigen-related (LAR) protein is a cell adhesion molecule-like receptor-type protein tyrosine phosphatase. We previously reported that in LAR…”
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Reduced Euchromatin histone methyltransferase 1 causes developmental delay, hypotonia, and cranial abnormalities associated with increased bone gene expression in Kleefstra syndrome mice
Published in Developmental biology (15-02-2014)“…Haploinsufficiency of Euchromatin histone methyltransferase 1 (EHMT1), a chromatin modifying enzyme, is the cause of Kleefstra syndrome (KS). KS is an…”
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Mixed‐methods exploration of students' motivation in using augmented reality in neuroanatomy education with prosected specimens
Published in Anatomical sciences education (01-08-2022)“…The use of augmented reality (AR) in teaching and studying neuroanatomy has been well researched. Previous research showed that AR‐based learning of…”
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Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation
Published in Scientific reports (10-01-2017)“…Heterozygous mutations or deletions of the human Euchromatin Histone Methyltransferase 1 ( EHMT1 ) gene are the main causes of Kleefstra syndrome, a…”
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12
Actual drawing of histological images improves knowledge retention
Published in Anatomical sciences education (01-01-2016)“…Medical students have to process a large amount of information during the first years of their study, which has to be retained over long periods of nonuse…”
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13
Structural and behavioural consequences of double deficiency for creatine kinases BCK and UbCKmit
Published in Behavioural brain research (28-02-2005)“…The cytosolic brain-type creatine kinase (BCK) isoform and the mitochondrial ubiquitous creatine kinase (UbCKmit) isoform are both important for the…”
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14
Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory
Published in Behavioural brain research (15-05-2014)“…•PTPRR isoforms are expressed throughout the mouse brain.•Ptprr knockout mice display normal olfactory bulb-related basal smell function.•In Ptprr knockout…”
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15
Conditional Deletion of the Itgb4 Integrin Gene in Schwann Cells Leads to Delayed Peripheral Nerve Regeneration
Published in The Journal of neuroscience (29-10-2008)“…Several different integrins participate in the complex interactions that promote repair of the peripheral nervous system. The role of the integrin alpha6beta4…”
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Creatine kinase B-driven energy transfer in the brain is important for habituation and spatial learning behaviour, mossy fibre field size and determination of seizure susceptibility
Published in The European journal of neuroscience (01-05-2002)“…Creatine kinases are important in maintaining cellular‐energy homeostasis, and neuroprotective effects have been attributed to the administration of creatine…”
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Complete brain‐type creatine kinase deficiency in mice blocks seizure activity and affects intracellular calcium kinetics
Published in Epilepsia (Copenhagen) (01-01-2010)“…Summary Purpose: Brain‐type creatine kinase (CK‐B) and ubiquitous mitochondrial creatine kinase (UbCKmit) act as components of local phosphocreatine ATP…”
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Survival of Cholinergic Forebrain Neurons in Developing p75$^{NGFR}$- Deficient Mice
Published in Science (American Association for the Advancement of Science) (06-12-1996)“…The functions of the low-affinity p75 nerve growth factor receptor (p75$^{NGFR}$) in the central nervous system were explored in vivo. In normal mice,…”
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PTPRR deficient mice display motor dysfunction
Published in Journal of neurochemistry (2007)“…The neuronal protein tyrosine phosphatases encoded by mouse gene Ptprr (PTPBR7, PTP-SL, PTPPBSγ-42 and PTPPBSγ-37) have been implicated in mitogen-activated…”
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Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury
Published in The European journal of neuroscience (01-05-2005)“…Using intact and lens‐lesioned wildtype, leucocyte common antigen‐related phosphatase deficient (LARΔP) and protein tyrosine phosphatase (PTP)‐BAS‐like…”
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