Search Results - "Zebol, Julia R."

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1 by Jarman, Kate E., Moretti, Paul A.B., Zebol, Julia R., Pitson, Stuart M.

“…SK1 (sphingosine kinase 1) plays an important role in many aspects of cellular regulation. Most notably, elevated cellular SK1 activity leads to increased cell…”
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A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties by Pitman, Melissa R, Powell, Jason A, Coolen, Carl, Moretti, Paul A B, Zebol, Julia R, Pham, Duyen H, Finnie, John W, Don, Anthony S, Ebert, Lisa M, Bonder, Claudine S, Gliddon, Briony L, Pitson, Stuart M

“…The dynamic balance of cellular sphingolipids, the sphingolipid rheostat, is an important determinant of cell fate, and is commonly deregulated in cancer…”
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The Nucleotide-binding Site of Human Sphingosine Kinase 1 by Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Zareie, Reza, Derian, Claudia K., Darrow, Andrew L., Qi, Jenson, D'Andrea, Richard J., Bagley, Christopher J., Vadas, Mathew A., Wattenberg, Binks W.

“…Sphingosine kinase catalyzes the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular…”
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Sphingosine 1‐phosphate is a ligand for peroxisome proliferator‐activated receptor‐γ that regulates neoangiogenesis by Parham, Kate A., Zebol, Julia R., Tooley, Katie L., Sun, Wai Y., Moldenhauer, Lachlan M., Cockshell, Michaelia P., Gliddon, Briony L., Moretti, Paul A., Tigyi, Gabor, Pitson, Stuart M., Bonder, Claudine S.

“…ABSTRACT Sphingosine 1‐phosphate (S1P) is a bio‐active lipid that can function both extracellularly and intracellularly to mediate a variety of cellular…”
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Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress by Wallington-Beddoe, Craig T, Bennett, Melissa K, Vandyke, Kate, Davies, Lorena, Zebol, Julia R, Moretti, Paul A B, Pitman, Melissa R, Hewett, Duncan R, Zannettino, Andrew C W, Pitson, Stuart M

“…The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production…”
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Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma by Neubauer, Heidi A., Tea, Melinda N., Zebol, Julia R., Gliddon, Briony L., Stefanidis, Cassandra, Moretti, Paul A. B., Pitman, Melissa R., Costabile, Maurizio, Kular, Jasreen, Stringer, Brett W., Day, Bryan W., Samuel, Michael S., Bonder, Claudine S., Powell, Jason A., Pitson, Stuart M.

“…While the two mammalian sphingosine kinases, SK1 and SK2, both catalyze the generation of pro-survival sphingosine 1-phosphate (S1P), their roles vary…”
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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation by Pitson, Stuart M, Moretti, Paul A.B, Zebol, Julia R, Lynn, Helen E, Xia, Pu, Vadas, Mathew A, Wattenberg, Binks W

“…Sphingosine kinase 1 is an agonist‐activated signalling enzyme that catalyses the formation of sphingosine 1‐phosphate, a lipid second messenger that has been…”
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An oncogenic role for sphingosine kinase 2 by Neubauer, Heidi A, Pham, Duyen H, Zebol, Julia R, Moretti, Paul A B, Peterson, Amanda L, Leclercq, Tamara M, Chan, Huasheng, Powell, Jason A, Pitman, Melissa R, Samuel, Michael S, Bonder, Claudine S, Creek, Darren J, Gliddon, Briony L, Pitson, Stuart M

“…While both human sphingosine kinases (SK1 and SK2) catalyze the generation of the pleiotropic signaling lipid sphingosine 1-phosphate, these enzymes appear to…”
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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling by Pitson, Stuart M, Xia, Pu, Leclercq, Tamara M, Moretti, Paul A B, Zebol, Julia R, Lynn, Helen E, Wattenberg, Binks W, Vadas, Mathew A

“…Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in…”
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The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1 by Zebol, Julia R., Hewitt, Niamh M., Moretti, Paul A.B., Lynn, Helen E., Lake, Julie A., Li, Peng, Vadas, Mathew A., Wattenberg, Binks W., Pitson, Stuart M.

“…Sphingosine kinase 1 (SK1) catalyses the generation of sphingosine 1-phosphate (S1P), a bioactive phospholipid that influences a diverse range of cellular…”
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Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation by Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Xia, Pu, Gamble, Jennifer R., Vadas, Mathew A., D'Andrea, Richard J., Wattenberg, Binks W.

“…Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell…”
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Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase by Pitson, S M, Moretti, P A, Zebol, J R, Xia, P, Gamble, J R, Vadas, M A, D'Andrea, R J, Wattenberg, B W

“…Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell…”
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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling by Pitson, Stuart M, Xia, Pu, Leclercq, Tamara M, Moretti, Paul A.B, Zebol, Julia R, Lynn, Helen E, Wattenberg, Binks W, Vadas, Mathew A

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A point mutant of human sphingosine kinase 1 with increased catalytic activity by M. Pitson, Stuart, Moretti, Paul A.B., Zebol, Julia R., Vadas, Mathew A., D’Andrea, Richard J., Wattenberg, Binks W.

“…Sphingosine kinase (SK) catalyses the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in mediating such fundamental…”
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