Search Results - "Zdunowski, Sharon"

Noninvasive Reactivation of Motor Descending Control after Paralysis by Gerasimenko, Yury P, Lu, Daniel C, Modaber, Morteza, Zdunowski, Sharon, Gad, Parag, Sayenko, Dimitry G, Morikawa, Erika, Haakana, Piia, Ferguson, Adam R, Roy, Roland R, Edgerton, V Reggie

“…The present prognosis for the recovery of voluntary control of movement in patients diagnosed as motor complete is generally poor. Herein we introduce a novel…”
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Weight Bearing Over-ground Stepping in an Exoskeleton with Non-invasive Spinal Cord Neuromodulation after Motor Complete Paraplegia by Gad, Parag, Gerasimenko, Yury, Zdunowski, Sharon, Turner, Amanda, Sayenko, Dimitry, Lu, Daniel C, Edgerton, V Reggie

“…We asked whether coordinated voluntary movement of the lower limbs could be regained in an individual having been completely paralyzed (>4 year) and completely…”
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Engaging Cervical Spinal Cord Networks to Reenable Volitional Control of Hand Function in Tetraplegic Patients by Lu, Daniel C., Edgerton, V. Reggie, Modaber, Morteza, AuYong, Nicholas, Morikawa, Erika, Zdunowski, Sharon, Sarino, Melanie E., Sarrafzadeh, Majid, Nuwer, Marc R., Roy, Roland R., Gerasimenko, Yury

“…Background. Paralysis of the upper limbs from spinal cord injury results in an enormous loss of independence in an individual’s daily life. Meaningful…”
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Minimal handgrip force is needed for transcutaneous electrical stimulation to improve hand functions of patients with severe spinal cord injury by Huang, Ruyi, Nikooyan, Ali A., Moore, Lisa D., Zdunowski, Sharon, Morikawa, Erika, Sierro, Tiffany, Sayenko, Dimitry, Gad, Parag, Homsey, Tali, Le, Timothy, Madhavan, Meghna A., Abdelshahid, Marina, Abdelshahid, Martina, Zhou, Yan, Nuwer, Mark R., Sarrafzadeh, Majid, Edgerton, V. Reggie, Leiter, James C., Lu, Daniel C.

“…Spinal cord stimulation enhanced restoration of motor function following spinal cord injury (SCI) in unblinded studies. To determine whether training combined…”
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Thoracolumbar epidural stimulation effects on bladder and bowel function in uninjured and chronic transected anesthetized rats by Hoey, Robert F., Medina-Aguiñaga, Daniel, Khalifa, Fahmi, Ugiliweneza, Beatrice, Wang, Dengzhi, Zdunowski, Sharon, Fell, Jason, Naglah, Ahmed, El-Baz, Ayman S., Herrity, April N., Harkema, Susan J., Hubscher, Charles H.

“…Pre-clinical studies have shown that spinal cord epidural stimulation (scES) at the level of pelvic and pudendal nerve inputs/outputs (L5-S1) alters storage…”
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Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats by Hoey, Robert F., Medina-Aguiñaga, Daniel, Khalifa, Fahmi, Ugiliweneza, Beatrice, Zdunowski, Sharon, Fell, Jason, Naglah, Ahmed, El-Baz, Ayman S., Herrity, April N., Harkema, Susan J., Hubscher, Charles H.

“…Spinal cord epidural stimulation (scES) mapping at L5-S1 was performed to identify parameters for bladder and bowel inhibition and/or contraction. Using…”
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Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury by Nout, Yvette S., Rosenzweig, Ephron S., Brock, John H., Strand, Sarah C., Moseanko, Rod, Hawbecker, Stephanie, Zdunowski, Sharon, Nielson, Jessica L., Roy, Roland R., Courtine, Gregoire, Ferguson, Adam R., Edgerton, V. Reggie, Beattie, Michael S., Bresnahan, Jacqueline C., Tuszynski, Mark H.

“…Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal…”
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Emergence of functionally aberrant and subsequent reduction of neuromuscular connectivity and improved motor performance after cervical spinal cord injury in Rhesus by Wai, Gregory, Zdunowski, Sharon, Zhong, Hui, Nielson, Jessica L, Ferguson, Adam R, Strand, Sarah C, Moseanko, Rod, Hawbecker, Stephanie, Nout-Lomas, Yvette S, Rosenzweig, Ephron S, Beattie, Michael S, Bresnahan, Jacqueline C, Tuszynski, Mark H, Roy, Roland R, Edgerton, V Reggie

“…The paralysis that occurs after a spinal cord injury, particularly during the early stages of post-lesion recovery (∼6 weeks), appears to be attributable to…”
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Methods for Functional Assessment After C7 Spinal Cord Hemisection in the Rhesus Monkey by Nout, Yvette S., Ferguson, Adam R., Strand, Sarah C., Moseanko, Rod, Hawbecker, Stephanie, Zdunowski, Sharon, Nielson, Jessica L., Roy, Roland R., Zhong, Hui, Rosenzweig, Ephron S., Brock, John H., Courtine, Grégoire, Edgerton, V. Reggie, Tuszynski, Mark H., Beattie, Michael S., Bresnahan, Jacqueline C.

“…Background. Reliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates. Measures need to be sensitive to both…”
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Accommodation of the spinal cat to a tripping perturbation by Zhong, Hui, Roy, Roland R, Nakada, Kenneth K, Zdunowski, Sharon, Khalili, Nicole, de Leon, Ray D, Edgerton, V Reggie

“…Adult cats with a complete spinal cord transection at T12-T13 can relearn over a period of days-to-weeks how to generate full weight-bearing stepping on a…”
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Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients by Freyvert, Yevgeniy, Yong, Nicholas Au, Morikawa, Erika, Zdunowski, Sharon, Sarino, Melanie E., Gerasimenko, Yury, Edgerton, V. Reggie, Lu, Daniel C.

“…The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were…”
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Epidural Stimulation Targeting Lower Urinary Tract Function in Spinally Intact and Transected Urethane‐Anesthetized Rats by Hubscher, Charles, Hoey, Robert, Medina-Aguinaga, Daniel, Khalifa, Fahmi, Zdunowski, Sharon, El-Baz, Ayman, Herrity, April, Harkema, Susan

“…Abstract only Bladder management for conditions such as spinal cord injury (SCI) includes a combination of catheterization (either self‐intermittent or…”
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Pronounced species divergence in corticospinal tract reorganization and functional recovery after lateralized spinal cord injury favors primates by Friedli, Lucia, Rosenzweig, Ephron S, Barraud, Quentin, Schubert, Martin, Dominici, Nadia, Awai, Lea, Nielson, Jessica L, Musienko, Pavel, Nout-Lomas, Yvette, Zhong, Hui, Zdunowski, Sharon, Roy, Roland R, Strand, Sarah C, van den Brand, Rubia, Havton, Leif A, Beattie, Michael S, Bresnahan, Jacqueline C, Bézard, Erwan, Bloch, Jocelyne, Edgerton, V Reggie, Ferguson, Adam R, Curt, Armin, Tuszynski, Mark H, Courtine, Grégoire

“…Experimental and clinical studies suggest that primate species exhibit greater recovery after lateralized compared to symmetrical spinal cord injuries…”
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Activation of spinal locomotor circuits in the decerebrated cat by spinal epidural and/or intraspinal electrical stimulation by Lavrov, Igor, Musienko, Pavel E, Selionov, Victor A, Zdunowski, Sharon, Roy, Roland R, Reggie Edgerton, V, Gerasimenko, Yury

“…Abstract The present study was designed to further compare the stepping-like movements generated via epidural (ES) and/or intraspinal (IS) stimulation. We…”
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Epidural Spinal Cord Stimulation Improves Motor Function in Rats With Chemically Induced Parkinsonism by Zhong, Hui, Zhu, Chunni, Minegishi, Yoshihiko, Richter, Franziska, Zdunowski, Sharon, Roy, Roland R., Vissel, Bryce, Gad, Parag, Gerasimenko, Yury, Chesselet, Marie-Francoise, Edgerton, V. Reggie

“…Background. Epidural stimulation of the spinal cord can reorganize and change the excitability of the neural circuitry to facilitate stepping in rats with a…”
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BDNF–exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats by Ying, Z, Roy, R.R, Zhong, H, Zdunowski, S, Edgerton, V.R, Gomez-Pinilla, F

“…Abstract Clinical evidence indicates that motor training facilitates functional recovery after a spinal cord injury (SCI). Brain-derived neurotrophic factor…”
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Development of a database for translational spinal cord injury research by Nielson, Jessica L, Guandique, Cristian F, Liu, Aiwen W, Burke, Darlene A, Lash, A Todd, Moseanko, Rod, Hawbecker, Stephanie, Strand, Sarah C, Zdunowski, Sharon, Irvine, Karen-Amanda, Brock, John H, Nout-Lomas, Yvette S, Gensel, John C, Anderson, Kim D, Segal, Mark R, Rosenzweig, Ephron S, Magnuson, David S K, Whittemore, Scott R, McTigue, Dana M, Popovich, Phillip G, Rabchevsky, Alexander G, Scheff, Stephen W, Steward, Oswald, Courtine, Grégoire, Edgerton, V Reggie, Tuszynski, Mark H, Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R

“…Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However,…”
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Engaging cervical spinal cord networks to re-enable volitional control of hand function in tetraplegic patients by Lu, Daniel C., Edgerton, V. Reggie, Modaber, Morteza, AuYong, Nicholas, Morikawa, Erika, Zdunowski, Sharon, Sarino, Melanie E., Nuwer, Marc R., Roy, Roland R., Gerasimenko, Yury

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Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury by Nielson, Jessica L, Haefeli, Jenny, Salegio, Ernesto A, Liu, Aiwen W, Guandique, Cristian F, Stück, Ellen D, Hawbecker, Stephanie, Moseanko, Rod, Strand, Sarah C, Zdunowski, Sharon, Brock, John H, Roy, Roland R, Rosenzweig, Ephron S, Nout-Lomas, Yvette S, Courtine, Gregoire, Havton, Leif A, Steward, Oswald, Reggie Edgerton, V, Tuszynski, Mark H, Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R

“…Abstract Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry…”
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Improvement of gait patterns in step-trained, complete spinal cord-transected rats treated with a peripheral nerve graft and acidic fibroblast growth factor by Lee, Yu-Shang, Zdunowski, Sharon, Edgerton, V. Reggie, Roy, Roland R., Zhong, Hui, Hsiao, Ian, Lin, Vernon W.

“…The effects of peripheral nerve grafts (PNG) and acidic fibroblast growth factor (αFGF) combined with step training on the locomotor performance of complete…”
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