Search Results - "Zdenek Hostomsky"

IOCB Prague – Excellent Basic Research and Successful Applications by Hostomský, Zdeněk

“…In this guest editorial Zdeněk Hostomský, the director of IOCB Prague introduces the history and long‐term success of this leading research institute…”
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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial by Thomas, Huw D, Calabrese, Christopher R, Batey, Michael A, Canan, Stacie, Hostomsky, Zdenek, Kyle, Suzanne, Maegley, Karen A, Newell, David R, Skalitzky, Donald, Wang, Lan-Zhen, Webber, Stephen E, Curtin, Nicola J

“…Poly(ADP-ribose) polymerase (PARP)-1 (EC 2.4.2.30) is a nuclear enzyme that promotes the base excision repair of DNA breaks. Inhibition of PARP-1 enhances the…”
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Base Excision Repair Is Impaired in Mammalian Cells Lacking Poly(ADP-ribose) Polymerase-1 by Dantzer, Françoise, de la Rubia, Guadelupe, Ménissier-de Murcia, Josiane, Hostomsky, Zdenek, de Murcia, Gilbert, Schreiber, Valérie

“…In mammalian cells, damaged bases in DNA are corrected by the base excision repair pathway which is divided into two distinct pathways depending on the length…”
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Inhibition of Poly(ADP-Ribose) Polymerase-1 Enhances Temozolomide and Topotecan Activity against Childhood Neuroblastoma by DANIEL, Rachel A, ROZANSKA, Agata L, CURTIN, Nicola J, CLIFFORD, Steven C, THOMAS, Huw D, MULLIGAN, Evan A, DREW, Yvette, CASTELBUONO, Deborah J, HOSTOMSKY, Zdenek, PLUMMER, E. Ruth, BODDY, Alan V, TWEDDLE, Deborah A

“…Purpose: High-risk neuroblastoma is characterized by poor survival rates, and the development of improved therapeutic approaches is a priority. Temozolomide…”
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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells by CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek

“…Purpose: Mismatch repair (MMR) deficiency confers resistance to temozolomide, a clinically active DNA-methylating agent. The purpose of the current study was…”
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Resistance-Modifying Agents. 9. Synthesis and Biological Properties of Benzimidazole Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase by White, Alex W, Almassy, Robert, Calvert, A. Hilary, Curtin, Nicola J, Griffin, Roger J, Hostomsky, Zdenek, Maegley, Karen, Newell, David R, Srinivasan, Sheila, Golding, Bernard T

“…The nuclear enzyme poly(ADP-ribose) polymerase (PARP) facilitates the repair of DNA strand breaks and is implicated in the resistance of cancer cells to…”
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The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site by Love, Robert A, Parge, Hans E, Wickersham, John A, Hostomsky, Zdenek, Habuka, Noriyuki, Moomaw, Ellen W, Adachi, Tsuyoshi, Hostomska, Zuzana

“…During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal…”
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Potentiation of Temozolomide and Topotecan Growth Inhibition and Cytotoxicity by Novel Poly(adenosine Diphosphoribose) Polymerase Inhibitors in a Panel of Human Tumor Cell Lines by DELANEY, C. A, WANG, L.-Z, KYLE, S, WHITE, A. W, CALVERT, A. H, CURTIN, N. J, DURKACZ, B. W, HOSTOMSKY, Z, NEWELL, D. R

“…Potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The…”
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Dicaffeoylquinic and Dicaffeoyltartaric Acids Are Selective Inhibitors of Human Immunodeficiency Virus Type 1 Integrase by MCDOUGALL, B, KING, P. J, BOR WEN WU, HOSTOMSKY, Z, REINECKE, M. G, ROBINSON, W. E

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase by Davies, Jay F., Hostomska, Zuzana, Hostomsky, Zdenek, Jordan, Steven R., Matthews, David A.

“…The crystal structure of the ribonuclease (RNase) H domain of HIV-1 reverse transcriptase (RT) has been determined at a resolution of 2.4…”
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Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors by Mukhopadhyay, Asima, Elattar, Ahmed, Cerbinskaite, Aiste, Wilkinson, Sarah J, Drew, Yvette, Kyle, Suzanne, Los, Gerrit, Hostomsky, Zdenek, Edmondson, Richard J, Curtin, Nicola J

“…Poly(ADP-ribose) polymerase (PARP) inhibitors selectively target homologous recombination (HR)-defective cells and show good clinical activity in hereditary…”
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Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2 by DREW, Yvette, MULLIGAN, Evan A, EDMONDSON, Richard J, CURTIN, Nicola J, VONG, Wan-Tse, THOMAS, Huw D, KAHN, Samra, KYLE, Suzanne, MUKHOPADHYAY, Asima, LOS, Gerrit, HOSTOMSKY, Zdenek, PLUMMER, Elizabeth R

“…Mutations in BRCA1 and BRCA2 (BRCA1/2), components of the homologous recombination DNA repair (HRR) pathway, are associated with hereditary breast and ovarian…”
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Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361 by CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne

“…Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy…”
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NF-κB mediates radio-sensitization by the PARP-1 inhibitor, AG-014699 by Hunter, J E, Willmore, E, Irving, J A E, Hostomsky, Z, Veuger, S J, Durkacz, B W

“…The stress-inducible transcription factor, nuclear factor (NF)-κB induces genes involved in proliferation and apoptosis. Aberrant NF-κB activity is common in…”
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Tricyclic Benzimidazoles as Potent Poly(ADP-ribose) Polymerase-1 Inhibitors by Skalitzky, Donald J, Marakovits, Joseph T, Maegley, Karen A, Ekker, Anne, Yu, Xiao-Hong, Hostomsky, Zdenek, Webber, Stephen E, Eastman, Brian W, Almassy, Robert, Li, Jianke, Curtin, Nicola J, Newell, David R, Calvert, A. Hilary, Griffin, Roger J, Golding, Bernard T

“…Novel tricyclic benzimidazole carboxamide poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been synthesized. Several compounds were found to be powerful…”
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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure by Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek

“…A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1), and the activity and physical properties…”
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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line by Fang, Douglas D., Cao, Joan, Jani, Jitesh P., Tsaparikos, Konstantinos, Blasina, Alessandra, Kornmann, Jill, Lira, Maruja E., Wang, Jianying, Jirout, Zuzana, Bingham, Justin, Zhu, Zhou, Gu, Yin, Los, Gerrit, Hostomsky, Zdenek, VanArsdale, Todd

“…Evaluating the effects of novel drugs on appropriate tumor models has become crucial for developing more effective therapies that target highly tumorigenic and…”
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Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies by CALABRESE, Christopher R, BATEY, Michael A, MAEGLEY, Karen, CALVERT, Alan H, HOSTOMSKY, Zdenek, NEWELL, David R, CURTIN, Nicola J, THOMAS, Huw D, DURKACZ, Barbara W, WANG, Lan-Zhen, KYLE, Suzanne, SKALITZKY, Donald, LI, Janke, ZHANG, Catherine, BORITZKI, Theodore

“…The nuclear enzyme poly(ADP-ribose) polymerase (PARP-1) facilitates DNA repair, and is, therefore, an attractive target for anticancer chemo- and…”
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Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors by White, Alex W., Curtin, Nicola J., Eastman, Brian W., Golding, Bernard T., Hostomsky, Zdenek, Kyle, Suzanne, Li, Jianke, Maegley, Karen A., Skalitzky, Donald J., Webber, Stephen E., Yu, Xiao-Hong, Griffin, Roger J.

“…The synthesis and biological evaluation of a new series of amine-substituted 2-arylbenzimidazole-4-carboxamide inhibitors of the DNA-repair enzyme…”
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High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus by Schneider, Daniel J, Feigon, Juli, Hostomsky, Zdenek, Gold, Larry

“…The reverse transcriptase (RT) of HIV-1 is a plausible target for therapeutic agents aimed at inhibiting propagation of the virus. We have used "irrational…”
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