Search Results - "Zbaida, S."

Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 351125, a CCR5 antagonist by Ghosal, A., Chowdhury, S. K., Gupta, S., Yuan, Y., Iannucci, R., Zhang, H., Zbaida, S., Patrick, J. E., Alton, K. B.

“…The identification and relative contribution of human cytochrome P450 enzyme(s) involved in the metabolism of SCH 351125 were investigated. In human liver…”
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Hepatic microsomal azoreductase activity. Reactivity of azo dye substrates is determined by their electron densities and redox potentials by Zbaida, S, Brewer, C F, Levine, W G

“…We have previously established that microsomal reduction of azo dyes requires polar electron-donating ring substituents [e.g. -OH, -NH2, -NHCH3, or -N(CH3)2]…”
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Role of electronic factors in binding and reduction of azo dyes by hepatic microsomes by Zbaida, S, Levine, W G

“…The factors which regulate the binding and reduction of azo dyes by rat liver microsomes have been investigated. Azo dyes having both electron-donating and…”
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In Vitro Uptake of SCH 27899 (Evernimicin) by Rat Alveolar Macrophages by ZBAIDA, Shmuel, BRIELAND, Joan, PATRICK, James E, KRIETER, Philip, LOEBENBERG, David, KRISHNA, Gopal, HORNE, Debra, LU, Xiaowen, YUAN YUAN, HARE, Roberta, CAYEN, Mitchell N

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Substrates for microsomal azoreductase. Hammett substituent effects, NMR studies, and response to inhibitors by Zbaida, S, Brewer, C F, Levine, W G

“…In previous studies on azoreduction by microsomal cytochrome P-450, we identified two classes of substrates structurally related to 4-dimethylaminoazobenzene…”
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IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ENZYME(S) RESPONSIBLE FOR THE GLUCURONIDATION OF EZETIMIBE (ZETIA) by GHOSAL, Anima, HAPANGAMA, Neil, YUAN YUAN, ACHANFUO-YEBOAH, Joana, LANNUCCI, Robert, CHOWDHURY, Swapan, ALTON, Kevin, PATRICK, James E, ZBAIDA, Shmuel

“…Ezetimibe [1-(4-fluorophenyl)-3( R )-[3-(4-fluorophenyl)-3( S )-hydroxypropyl]-4( S )-(4-hydroxyphenyl)-2-azetidinone] (Zetia; Schering-Plough, Kenilworth, NJ)…”
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In vitro metabolism of 10-(3-chlorophenyl)-6,8,9,10-tetrahydrobenzo[b][1,8]naphthyridin-5(7H)-one, a topical antipsoriatic agent. Use of precision-cut rat, dog, monkey and human liver slices, and chemical synthesis of metabolites by Zbaida, Shmuel, Du, Yancy, Shannon, Daniel, Laudicina, Donald, Thonoor, C. Mohan, Ng, Kwokei, Blumenkrantz, Neil, Patrick, James E., Cayen, Mitchell N., Friary, Richard, Seidl, Vera, Chan, Tze-Ming, Pramanik, Birendra, Spangler, Michael, McPhail, Andrew T.

“…The metabolism of SCH 40120, which is the clinically effective antipsoriatic drug 10‐(3‐chlorophenyl)‐6,8,9,10‐tetrahydrobenzol[b][1,8]naphthyridin‐5(7H)‐one,…”
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Multiple mechanisms in hepatic microsomal azoreduction by Levine, W G, Stoddart, A, Zbaida, S

“…1. Microsomal reduction of azo dyes related to dimethylaminoazobenzene (DAB) is catalysed by at least two types of cytochrome P-450. The first is selectively…”
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Reactions of theophylline, theobromine and caffeine with Fenton's reagent--simulation of hepatic metabolism by Zbaida, S, Kariv, R, Fischer, P, Gilhar, D

“…Theophylline and caffeine undergo N-demethylation and hydroxylation by Fenton's reagent to give uric acid derivatives; theophylline is oxidized mainly to…”
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IDENTIFICATION OF HUMAN UDP-GLUCURONOSYLTRANSFERASE ENZYME(S) RESPONSIBLE FOR THE GLUCURONIDATION OF POSACONAZOLE (NOXAFIL) by GHOSAL, Anima, HAPANGAMA, Neil, YUAN YUAN, ACHANFUO-YEBOAH, Joana, LANNUCCI, Robert, CHOWDHURY, Swapan, ALTON, Kevin, PATRICK, James E, ZBAIDA, Shmuel

“…Posaconazole (Noxafil, SCH 56592), an orally available broad-spectrum triazole antifungal, is currently in phase III clinical studies for treating serious…”
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Rapid determination of enzyme activities of recombinant human cytochromes P450, human liver microsomes and hepatocytes by Ghosal, Anima, Hapangama, Neil, Yuan, Yuan, Lu, Xiaowen, Horne, Debra, Patrick, James E., Zbaida, Shmuel

“…Cytochrome P450 (CYP) substrates that yield fluorescent metabolites were used for rapid screening of drug metabolism activities of 13 recombinant human…”
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Observation of pentacoordinated phosphorus intermediate in the reactions of nitrones with phosphonate anions by Zbaida, S., Breuer, E.

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The mechanism of microsomal azoreduction: predictions based on electronic aspects of structure-activity relationships by Zbaida, S

“…The mechanism of microsomal azoreductase is regulated by the overall Hammett sigma substituent values on each ring. A substrate dye must exhibit an overall…”
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Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine by Ghosal, Anima, Yuan, Yuan, Hapangama, Neil, Su, Ai Duen (Iris), Alvarez, Narciso, Chowdhury, Swapan K., Alton, Kevin B., Patrick, James E., Zbaida, Shmuel

“…Desloratadine is a non‐sedating antihistamine recently approved for the treatment of seasonal allergic rhinitis. The major metabolite of desloratadine in human…”
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IDENTIFICATION OF HUMAN LIVER CYTOCHROME P450 ENZYMES RESPONSIBLE FOR THE METABOLISM OF LONAFARNIB (SARASAR) by GHOSAL, Anima, CHOWDHURY, Swapan K, WEI TONG, HAPANGAMA, Neil, YUAN YUAN, SU, Ai-Duen, ZBAIDA, Shmuel

“…Lonafarnib (Sarasar), a farnesyl transferase inhibitor, is currently under development for the treatment of solid tumors. Incubation of lonafarnib with human…”
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Two classes of azo dye reductase activity associated with rat liver microsomal cytochrome P-450 by Levine, W G, Zbaida, S

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A novel application of cyclic voltammetry for direct investigation of metabolic intermediates in microsomal azo reduction by Zbaida, Shmuel, Levine, Walter G

“…We have established that reduction of azo dyes structurally related to 4-(dimethylamino)-azobenzene (DAB) by rat liver microsomal cytochrome P-450 requires a…”
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Characteristics of two classes of azo dye reductase activity associated with rat liver microsomal cytochrome P450 by Zbaida, S, Levine, W G

“…Azo dyes are reduced to primary amines by the microsomal enzymes NADPH-cytochrome P450 reductase and cytochrome P450. Amaranth, a highly polar dye, is reduced…”
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Simulation of the hepatic metabolism of stilbene and its tricyclic derivatives by Fenton and Ruff reagents: models for cytochrome P-450 activation of chemical carcinogens by Zbaida, S, Kariv, R

“…Reactions of trans-stilbene, cis-stilbene, 5H-dibenzo [a,d] cyclo-heptene 5-one and 5H-dibenz [b,f] azepine (iminostilbene) with Fenton reagent [Fe (II)/H2O2]…”
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The role of iron chelates on the selectivity of Fenton reagent in hydroxylation, N-demethylation, and sulfoxidation of cimetidine: a novel biomimetic model for the regioselectivity of cytochrome P-450 by Zbaida, S, Kariv, R, Fischer, P

“…The effect of iron chelates on the reaction of cimetidine with Fenton reagent [Fe(II)/H2O2] has been investigated. Iron chelates with high affinity to ferrous…”
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