The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words

The Association of Brain-Derived Neurotrophic Factor and Serotonin Transporter Genes with the Parameters of Early Event-Related Potentials During the Passive Perception of Words

We explored the association of brain-derived neurotrophic factor (BDNF) and serotonin transporter genes with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and heal...

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Bibliographic Details
Published in:Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 66; no. 5; p. 556
Main Authors: Golimbet, V E, Garakh, Zh V, Korovaitseva, G I, Lezheiko, T V, Zaytsevac, Yu S, I Ya Gurovich, Shmukler, A B, Rodionov, G I, Strelets, V B
Format: Journal Article
Language:Russian
Published: Russia (Federation) 01-09-2016
Subjects:
Adolescent
Adult
Alleles
Brain-Derived Neurotrophic Factor - genetics
Case-Control Studies
Cognition - physiology
Evoked Potentials, Auditory - physiology
Female
Gene Expression
Humans
Male
Middle Aged
Polymorphism, Genetic
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - genetics
Psychotic Disorders - physiopathology
Russia
Schizophrenia - diagnostic imaging
Schizophrenia - genetics
Schizophrenia - physiopathology
Schizotypal Personality Disorder - diagnostic imaging
Schizotypal Personality Disorder - genetics
Schizotypal Personality Disorder - physiopathology
Serotonin Plasma Membrane Transport Proteins - genetics
Speech - physiology
Speech Perception - physiology
Russia
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Description
Summary:We explored the association of brain-derived neurotrophic factor (BDNF) and serotonin transporter genes with neurophysiological characteristics of the early stages of verbal information processing in the brain in the groups of patients with schizophrenia and schizophrenia spectrum disorders and healthy people. It has been shown that Val66Met and 5-HTTLPR polymorphisms are associated with P100 and N170 during the passive reading of single words written in Russian presented with different occurrence frequency. The healthy carriers of the ValVal genotype (BDN F Val66Met) allele or the SS (5-HTTLPR) genotype performed the task better compared to those with an Met or an L allele. The differences were significant in healthy people and observed as a trend in thepatients.
ISSN:0044-4677
DOI:10.7868/S0044467716040043