Relationships of glycoproteins IIb-IIIa and Ib content with mean platelet volume and their genetic polymorphisms

Quantity of platelet adhesion molecules significantly varies in normal donors and cardiovascular patients and might be affected by platelet size and genetic variations. In this study, we assessed relationships of the content of glycoprotein (GP) IIb-IIIa and GPIb with mean platelet volume (MPV) and...

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Published in:	Blood coagulation & fibrinolysis Vol. 25; no. 2; pp. 128 - 134
Main Authors:	Khaspekova, Svetlana G, Zyuryaev, Ilia T, Yakushkin, Vladimir V, Sirotkina, Olga V, Zaytseva, Natalia O, Ruda, Mikhail Y, Panteleev, Mikhail A, Mazurov, Alexey V
Format:	Journal Article
Language:	English
Published:	England Wolters Kluwer Health \| Lippincott Williams & Wilkins 01-03-2014
Subjects:	Acute Coronary Syndrome - blood Acute Coronary Syndrome - genetics Acute Coronary Syndrome - metabolism Female Humans Male Mean Platelet Volume - methods Middle Aged Platelet Adhesiveness Platelet Glycoprotein GPIIb-IIIa Complex - genetics Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Polymorphism, Genetic
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Summary:	Quantity of platelet adhesion molecules significantly varies in normal donors and cardiovascular patients and might be affected by platelet size and genetic variations. In this study, we assessed relationships of the content of glycoprotein (GP) IIb-IIIa and GPIb with mean platelet volume (MPV) and their genetic polymorphisms. MPV and GPIIb-IIIa and GPIb numbers were measured in 116 patients with acute coronary syndrome (ACS) at days 1, 3–5 and 8–12 after disease onset and in 32 healthy volunteers. GPIIb-IIIa and GPIb allelic variants were determined in ACS patients. Strong interactions of GPIIb-IIIa and GPIb numbers and MPV were observed in ACS patients and healthy volunteers. In patients, coefficients of correlation (r) were 0.642 and 0.510 (analysis of individual mean values) and in volunteers – 0.594 and 0.508 for GPIIb-IIIa and GPIb, respectively (everywhere P < 0.005). In ACS patients, correlations were highly significant at each tested time point. GPIIb-IIIa and GPIb genetic polymorphisms [GPIIIa Leu33Pro, GPIbα Thr145Met and GPIbα (−5)T/C (Kozak)] determined in ACS patients had no significant impact on their expression. Modest correlation was revealed between MPV and plasma thrombopoietin (TPO) measured at the first day of ACS (r = 0.279, P = 0.005). The data obtained indicated that GPIIb-IIIa and GPIb levels are mainly affected by platelet size (MPV) but not by their genetic variations. In some ACS patients, production of large platelets with high GPIIb-IIIa and GPIb contents might be stimulated by elevated TPO.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0957-5235 1473-5733
DOI:	10.1097/MBC.0b013e328364b025