Search Results - "Zaw Thin, May"

CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth by Wang, Victoria M.-Y., Ferreira, Rute M. M., Almagro, Jorge, Evan, Theodore, Legrave, Nathalie, Zaw Thin, May, Frith, David, Carvalho, Joana, Barry, David J., Snijders, Ambrosius P., Herbert, Eleanor, Nye, Emma L., MacRae, James I., Behrens, Axel

“…Pancreatic ductal adenocarcinoma (PDAC) shows great cellular heterogeneity, with pronounced epithelial and mesenchymal cancer cell populations. However, the…”
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Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress by Schug, Zachary T., Peck, Barrie, Jones, Dylan T., Zhang, Qifeng, Grosskurth, Shaun, Alam, Israt S., Goodwin, Louise M., Smethurst, Elizabeth, Mason, Susan, Blyth, Karen, McGarry, Lynn, James, Daniel, Shanks, Emma, Kalna, Gabriela, Saunders, Rebecca E., Jiang, Ming, Howell, Michael, Lassailly, Francois, Thin, May Zaw, Spencer-Dene, Bradley, Stamp, Gordon, van den Broek, Niels J.F., Mackay, Gillian, Bulusu, Vinay, Kamphorst, Jurre J., Tardito, Saverio, Strachan, David, Harris, Adrian L., Aboagye, Eric O., Critchlow, Susan E., Wakelam, Michael J.O., Schulze, Almut, Gottlieb, Eyal

“…A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted…”
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USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer by Nelson, Jessica K., Thin, May Zaw, Evan, Theodore, Howell, Steven, Wu, Mary, Almeida, Bruna, Legrave, Nathalie, Koenis, Duco S., Koifman, Gabriela, Sugimoto, Yoichiro, Llorian Sopena, Miriam, MacRae, James, Nye, Emma, Howell, Michael, Snijders, Ambrosius P., Prachalias, Andreas, Zen, Yoh, Sarker, Debashis, Behrens, Axel

“…Deubiquitylating enzymes (DUBs) play an essential role in targeted protein degradation and represent an emerging therapeutic paradigm in cancer. However, their…”
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GREM1 is required to maintain cellular heterogeneity in pancreatic cancer by Lan, Linxiang, Evan, Theodore, Li, Huafu, Hussain, Aasia, Ruiz, E. Josue, Zaw Thin, May, Ferreira, Rute M. M., Ps, Hari, Riising, Eva M., Zen, Yoh, Almagro, Jorge, Ng, Kevin W., Soro-Barrio, Pablo, Nelson, Jessica, Koifman, Gabriela, Carvalho, Joana, Nye, Emma L., He, Yulong, Zhang, Changhua, Sadanandam, Anguraj, Behrens, Axel

“…Pancreatic ductal adenocarcinoma (PDAC) shows pronounced epithelial and mesenchymal cancer cell populations 1 – 4 . Cellular heterogeneity in PDAC is an…”
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Multi-modal imaging probe for assessing the efficiency of stem cell delivery to orthotopic breast tumours by Zaw Thin, May, Allan, Helen, Bofinger, Robin, Kostelec, Tomas D, Guillaume, Simon, Connell, John J, Patrick, P Stephen, Hailes, Helen C, Tabor, Alethea B, Lythgoe, Mark F, Stuckey, Daniel J, Kalber, Tammy L

“…Stem cells have been utilised as anti-cancer agents due to their ability to home to and integrate within tumours. Methods to augment stem cell homing to…”
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Stem cell delivery to kidney via minimally invasive ultrasound-guided renal artery injection in mice by Zaw Thin, May, Ogunlade, Olumide, Comenge, Joan, Patrick, P. Stephen, Stuckey, Daniel J., David, Anna L., Lythgoe, Mark F., Beard, Paul, Kalber, Tammy L.

“…Cell-based therapies are promising treatments for various kidney diseases. However, the major hurdle in initiating therapeutic responses is the inefficiency of…”
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Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse by Ryan, Sean G., Butler, Matthew N., Adeyemi, Segun S., Kalber, Tammy, Patrick, P. Stephen, Zaw Thin, May, Harrison, Ian F., Stuckey, Daniel J., Pule, Martin, Lythgoe, Mark F.

“…Optical imaging in clinical and preclinical settings can provide a wealth of biological information, particularly when coupled with targetted nanoparticles,…”
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Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes by Bofinger, Robin, Zaw‐Thin, May, Mitchell, Nicholas J., Patrick, P. Stephen, Stowe, Cassandra, Gomez‐Ramirez, Ana, Hailes, Helen C., Kalber, Tammy L., Tabor, Alethea B.

“…The design, synthesis and formulation of non‐viral gene delivery vectors is an area of renewed research interest. Amongst the most efficient non‐viral gene…”
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Tissue clearing to examine tumour complexity in three dimensions by Almagro, Jorge, Messal, Hendrik A., Zaw Thin, May, van Rheenen, Jacco, Behrens, Axel

“…The visualization of whole organs and organisms through tissue clearing and fluorescence volumetric imaging has revolutionized the way we look at biological…”
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Antigen retrieval and clearing for whole-organ immunofluorescence by FLASH by Messal, Hendrik A., Almagro, Jorge, Zaw Thin, May, Tedeschi, Antonio, Ciccarelli, Alessandro, Blackie, Laura, Anderson, Kurt I., Miguel-Aliaga, Irene, van Rheenen, Jacco, Behrens, Axel

“…Advances in light-sheet and confocal microscopy now allow imaging of cleared large biological tissue samples and enable the 3D appreciation of cell and protein…”
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VEROnA Protocol: A Pilot, Open-Label, Single-Arm, Phase 0, Window-of-Opportunity Study of Vandetanib-Eluting Radiopaque Embolic Beads (BTG-002814) in Patients With Resectable Liver Malignancies by Beaton, Laura, Tregidgo, Henry F J, Znati, Sami A, Forsyth, Sharon, Clarkson, Matthew J, Bandula, Steven, Chouhan, Manil, Lowe, Helen L, Zaw Thin, May, Hague, Julian, Sharma, Dinesh, Pollok, Joerg-Matthias, Davidson, Brian R, Raja, Jowad, Munneke, Graham, Stuckey, Daniel J, Bascal, Zainab A, Wilde, Paul E, Cooper, Sarah, Ryan, Samantha, Czuczman, Peter, Boucher, Eveline, Hartley, John A, Lewis, Andrew L, Jansen, Marnix, Meyer, Tim, Sharma, Ricky A

“…Transarterial chemoembolization (TACE) is the current standard of care for patients with intermediate-stage hepatocellular carcinoma (HCC) and is also a…”
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Requirement for Interaction of PI3-Kinase p110α with RAS in Lung Tumor Maintenance by Castellano, Esther, Sheridan, Clare, Thin, May Zaw, Nye, Emma, Spencer-Dene, Bradley, Diefenbacher, Markus E., Moore, Christopher, Kumar, Madhu S., Murillo, Miguel M., Grönroos, Eva, Lassailly, Francois, Stamp, Gordon, Downward, Julian

“…RAS proteins directly activate PI3-kinases. Mice bearing a germline mutation in the RAS binding domain of the p110α subunit of PI3-kinse are resistant to the…”
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Image-guided Raman spectroscopy probe-tracking for tumor margin delineation by Horgan, Conor C, Bergholt, Mads S, Thin, May Zaw, Nagelkerke, Anika, Kennedy, Robert, Kalber, Tammy L, Stuckey, Daniel J, Stevens, Molly M

“…Significance: Tumor detection and margin delineation are essential for successful tumor resection. However, postsurgical positive margin rates remain high for…”
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Fucoidan Prolongs the Circulation Time of Dextran-Coated Iron Oxide Nanoparticles by Abdollah, Maha R. A, Carter, Thomas J, Jones, Clare, Kalber, Tammy L, Rajkumar, Vineeth, Tolner, Berend, Gruettner, Cordula, Zaw-Thin, May, Baguña Torres, Julia, Ellis, Matthew, Robson, Mathew, Pedley, R. Barbara, Mulholland, Paul, T. M. de Rosales, Rafael, Chester, Kerry Ann

“…The magnetic properties and safety of dextran-coated superparamagnetic iron oxide nanoparticles (SPIONs) have facilitated their clinical use as MRI contrast…”
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Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation by Carter, Thomas J., Agliardi, Giulia, Lin, Fang‐Yu, Ellis, Matthew, Jones, Clare, Robson, Mathew, Richard‐Londt, Angela, Southern, Paul, Lythgoe, Mark, Zaw Thin, May, Ryzhov, Vyacheslav, Rosales, Rafael T. M., Gruettner, Cordula, Abdollah, Maha R. A., Pedley, R. Barbara, Pankhurst, Quentin A., Kalber, Tammy L., Brandner, Sebastian, Quezada, Sergio, Mulholland, Paul, Shevtsov, Maxim, Chester, Kerry

“…Magnetic hyperthermia (MH) harnesses the heat‐releasing properties of superparamagnetic iron oxide nanoparticles (SPIONs) and has potential to stimulate immune…”
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Scalable magnet geometries enhance tumour targeting of magnetic nano-carriers by Mohseni, Matin, Connell, John J., Payne, Christopher, Patrick, P. Stephen, Baker, Rebecca, Yu, Yichao, Siow, Bernard, Zaw-Thin, May, Kalber, Tammy L., Pankhurst, Quentin A., Lythgoe, Mark F.

“…Targeted drug delivery systems aim to increase therapeutic effect within the target tissue or organ, while reducing off-target toxicity associated with…”
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Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT by Patrick, P. Stephen, Kolluri, Krishna K, Zaw Thin, May, Edwards, Adam, Sage, Elizabeth K, Sanderson, Tom, Weil, Benjamin D, Dickson, John C, Lythgoe, Mark F, Lowdell, Mark, Janes, Sam M, Kalber, Tammy L

“…Abstract Background MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer…”
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Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring by Horgan, Conor C, Bergholt, Mads S, Nagelkerke, Anika, Thin, May Zaw, Pence, Isaac J, Kauscher, Ulrike, Kalber, Tammy L, Stuckey, Daniel J, Stevens, Molly M

“…Theranostics, the combination of diagnosis and therapy, has long held promise as a means to achieving personalised precision cancer treatments. However,…”
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Myocardial Viability Imaging using Manganese‐Enhanced MRI in the First Hours after Myocardial Infarction by Jasmin, Nur Hayati, Thin, May Zaw, Johnson, Robert D., Jackson, Laurence H., Roberts, Thomas A., David, Anna L., Lythgoe, Mark F., Yang, Philip C., Davidson, Sean M., Camelliti, Patrizia, Stuckey, Daniel J.

“…Early measurements of tissue viability after myocardial infarction (MI) are essential for accurate diagnosis and treatment planning but are challenging to…”
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Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice by Zaw Thin, May, Moore, Christopher, Snoeks, Thomas, Kalber, Tammy, Downward, Julian, Behrens, Axel

“…X-ray computed tomography is a reliable technique for the detection and longitudinal monitoring of pulmonary nodules. In preclinical stages of diagnostic or…”
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