Surge of severe acute respiratory syndrome coronavirus 2 infections linked to single introduction of a virus strain in Myanmar, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major health concern globally. Genomic epidemiology is an important tool to assess the pandemic of coronavirus disease 2019 (COVID-19). Several mutations have been reported by genome analysis of the SARS-CoV-2. In the presen...

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Published in:	Scientific reports Vol. 11; no. 1; p. 10203
Main Authors:	Nyunt, Myat Htut, Soe, Hnin Ohnmar, Aye, Kay Thi, Aung, Wah Wah, Kyaw, Yi Yi, Kyaw, Aung Kyaw, Myat, Theingi Win, Latt, Aung Zaw, Win, Min Min, Win, Aye Aye, Htun, Yin Min, Zaw, Khaing Mar, Ei, Phyu Win, Hein, Kyaw Thu, San, Lai Lai, Oo, Nan Aye Thida, Lin, Htin, Mon, Nan Cho Nwe, Yee, Khin Than, Htun, Khin Lapyae, Aye, Lynn Pa Pa, Ko, Yamin Ko, Htoo, Thitsar Htet Htet, Aung, Kham Mo, Azili, Hnin, Han, Soe Soe, Zaw, Ni Ni, Win, Su Mon, Thwe, Wai Myat, Aye, Thin Thin, Hlaing, Myat Su, Minn, Wai Yan, Thu, Pyae Phyo, Thu, Hlaing Myat, Htun, Zaw Than
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13-05-2021 Nature Publishing Group Nature Portfolio
Subjects:	631/208 631/326 631/337 692/4017 692/699 Coronaviridae Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 - virology Disease control Disease transmission Epidemiology Genome, Viral Genomes Genomics Humanities and Social Sciences Humans Infections multidisciplinary Mutation Myanmar - epidemiology Pandemics Phylogeny SARS-CoV-2 - genetics SARS-CoV-2 - isolation & purification Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Whole Genome Sequencing Myanmar India
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Summary:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a major health concern globally. Genomic epidemiology is an important tool to assess the pandemic of coronavirus disease 2019 (COVID-19). Several mutations have been reported by genome analysis of the SARS-CoV-2. In the present study, we investigated the mutational and phylogenetic analysis of 30 whole-genome sequences for the virus's genomic characteristics in the specimens collected in the early phase of the pandemic (March–June, 2020) and the sudden surge of local transmission (August–September, 2020). The four samples in the early phase of infection were B.6 lineage and located within a clade of the samples collected at the same time in Singapore and Malaysia, while five returnees by rescue flights showed the lineage B. 1.36.1 (three from India), B.1.1 (one from India) and B.1.80 (one from China). However, there was no evidence of local spread from these returnees. Further, all 19 whole-genome sequences collected in the sudden surge of local transmission showed lineage B.1.36. The surge of the second wave on SARS-CoV-2 infection was linked to the single-introduction of a variant (B.1.36) that may result from the strict restriction of international travel and containment efforts. These genomic data provides the useful information to disease control and prevention strategy.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-89361-7