Search Results - "Zavros, Yana"

Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells by Zavros, Yana

“…Gastric cancer is the third most common cause of cancer-related death. Although the incidence of gastric cancer in the United States is relatively low, it…”
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Organoid Models of Human Gastrointestinal Development and Disease by Dedhia, Priya H, Bertaux-Skeirik, Nina, Zavros, Yana, Spence, Jason R

“…We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell–derived gastrointestinal (GI) tissues in vitro. These…”
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Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection by Holokai, Loryn, Chakrabarti, Jayati, Broda, Taylor, Chang, Julie, Hawkins, Jennifer A, Sundaram, Nambirajan, Wroblewski, Lydia E, Peek, Jr, Richard M, Wang, Jiang, Helmrath, Michael, Wells, James M, Zavros, Yana

“…Helicobacter pylori (H. pylori) is the major risk factor for the development of gastric cancer. Our laboratory has reported that the Sonic Hedgehog (Shh)…”
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Role of metaplasia during gastric regeneration by Teal, Emma, Dua-Awereh, Martha, Hirshorn, Sabrina T, Zavros, Yana

“…Spasmolytic polypeptide/trefoil factor 2 (TFF2)-expressing metaplasia (SPEM) is a mucous-secreting reparative lineage that emerges at the ulcer margin in…”
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Leveraging the predictive power of 3D organoids in dogs to develop new treatments for man and man's best friend by Allenspach, Karin, Zavros, Yana, Elbadawy, Mohamed, Zdyrski, Christopher, Mochel, Jonathan Paul

“…Recent progress in adult stem cell technology, along with interdisciplinary collaboration in the field of One Health, has accelerated the development of 3D…”
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Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis by Pond, Kelvin W, Morris, Julia M, Alkhimenok, Olga, Varghese, Reeba P, Cabel, Carly R, Ellis, Nathan A, Chakrabarti, Jayati, Zavros, Yana, Merchant, Juanita L, Thorne, Curtis A, Paek, Andrew L

“…The establishment and maintenance of different cellular compartments in tissues is a universal requirement across all metazoans. Maintaining the correct ratio…”
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The use of murine‐derived fundic organoids in studies of gastric physiology by Schumacher, Michael A., Aihara, Eitaro, Feng, Rui, Engevik, Amy, Shroyer, Noah F., Ottemann, Karen M., Worrell, Roger T., Montrose, Marshall H., Shivdasani, Ramesh A., Zavros, Yana

“…Key points An in vitro approach to study gastric development is primary mouse‐derived epithelium cultured as three‐dimensional spheroids known as organoids. We…”
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CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation by Bertaux-Skeirik, Nina, Feng, Rui, Schumacher, Michael A, Li, Jing, Mahe, Maxime M, Engevik, Amy C, Javier, Jose E, Peek, Jr, Richard M, Ottemann, Karen, Orian-Rousseau, Veronique, Boivin, Gregory P, Helmrath, Michael A, Zavros, Yana

“…The cytotoxin-associated gene (Cag) pathogenicity island is a strain-specific constituent of Helicobacter pylori (H. pylori) that augments cancer risk. CagA…”
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The adventures of sonic hedgehog in development and repair. IV. Sonic hedgehog processing, secretion, and function in the stomach by Zavros, Yana

“…Sonic hedgehog (Shh) is recognized as one of the main morphogens that regulates cell differentiation during early development of the stomach. In the adult…”
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An Organoid-Based Preclinical Model of Human Gastric Cancer by Steele, Nina G, Chakrabarti, Jayati, Wang, Jiang, Biesiada, Jacek, Holokai, Loryn, Chang, Julie, Nowacki, Lauren M, Hawkins, Jennifer, Mahe, Maxime, Sundaram, Nambirajan, Shroyer, Noah, Medvedovic, Mario, Helmrath, Michael, Ahmad, Syed, Zavros, Yana

“…Background & Aims Our goal was to develop an initial study for the proof of concept whereby gastric cancer organoids are used as an approach to predict the…”
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The Novel Role of Lgr5 as a Regulator of Cell Homeostasis and Disease of the Gastric Oxyntic Mucosa by Zavros, Yana, PhD

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Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning by Watson, Adam W., Grant, Adam D., Parker, Sara S., Hill, Samantha, Whalen, Michael B., Chakrabarti, Jayati, Harman, Michael W., Roman, Mackenzie R., Forte, Brittany L., Gowan, Cody C., Castro-Portuguez, Raúl, Stolze, Lindsey K., Franck, Christian, Cusanovich, Darren A., Zavros, Yana, Padi, Megha, Romanoski, Casey E., Mouneimne, Ghassan

“…While the immediate and transitory response of breast cancer cells to pathological stiffness in their native microenvironment has been well explored, it…”
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H. pylori infection confers resistance to apoptosis via Brd4-dependent BIRC3 eRNA synthesis by Chen, Yanheng, Sheppard, Donald, Dong, Xingchen, Hu, Xiangming, Chen, Meihua, Chen, Ruichuan, Chakrabarti, Jayati, Zavros, Yana, Peek, Richard M., Chen, Lin-Feng

“…H. pylori infection is one of the leading causes of gastric cancer and the pathogenicity of H. pylori infection is associated with its ability to induce…”
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Gastric Sonic Hedgehog Acts as a Macrophage Chemoattractant During the Immune Response to Helicobacter pylori by Schumacher, Michael A, Donnelly, Jessica M, Engevik, Amy C, Xiao, Chang, Yang, Li, Kenny, Susan, Varro, Andrea, Hollande, Frédéric, Samuelson, Linda C, Zavros, Yana

“…Background & Aims Macrophages mediate the epithelial response to Helicobacter pylori and are involved in the development of gastritis. Sonic Hedgehog (Shh)…”
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Oncogenic Transformation of Human-Derived Gastric Organoids by Bertaux-Skeirik, Nina, Centeno, Jomaris, Gao, Jian, Gabre, Joel, Zavros, Yana

“…The culture of organoids has represented a significant advancement in the gastrointestinal research field. Previous research studies have described the…”
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CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium by Bertaux‐Skeirik, Nina, Wunderlich, Mark, Teal, Emma, Chakrabarti, Jayati, Biesiada, Jacek, Mahe, Maxime, Sundaram, Nambirajan, Gabre, Joel, Hawkins, Jennifer, Jian, Gao, Engevik, Amy C, Yang, Li, Wang, Jiang, Goldenring, James R, Qualls, Joseph E, Medvedovic, Mario, Helmrath, Michael A, Diwan, Tayyab, Mulloy, James C, Zavros, Yana

“…The CD44 gene encodes several protein isoforms due to alternative splicing and post translational modifications. Given that CD44 variant isoform 9 (CD44v9) is…”
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Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium by Chakrabarti, Jayati, Dua-Awereh, Martha, Schumacher, Michael, Engevik, Amy, Hawkins, Jennifer, Helmrath, Michael A., Zavros, Yana

“…Sonic Hedgehog (Shh), secreted from gastric parietal cells, contributes to the regeneration of the epithelium. The recruitment of macrophages plays a central…”
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Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori by Aihara, Eitaro, Closson, Chet, Matthis, Andrea L, Schumacher, Michael A, Engevik, Amy C, Zavros, Yana, Ottemann, Karen M, Montrose, Marshall H

“…Helicobacter pylori (H. pylori) is a pathogen contributing to peptic inflammation, ulceration, and cancer. A crucial step in the pathogenic sequence is when…”
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Spatial and Temporal Shifts in Bacterial Biogeography and Gland Occupation during the Development of a Chronic Infection by Keilberg, Daniela, Zavros, Yana, Shepherd, Benjamin, Salama, Nina R, Ottemann, Karen M

“…Gland colonization may be one crucial route for bacteria to maintain chronic gastrointestinal infection. We developed a quantitative gland isolation method to…”
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Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid by Aihara, Eitaro, Mahe, Maxime M., Schumacher, Michael A., Matthis, Andrea L., Feng, Rui, Ren, Wenwen, Noah, Taeko K., Matsu-ura, Toru, Moore, Sean R., Hong, Christian I., Zavros, Yana, Herness, Scott, Shroyer, Noah F., Iwatsuki, Ken, Jiang, Peihua, Helmrath, Michael A., Montrose, Marshall H.

“…Leucine-rich repeat-containing G-protein coupled receptor 5-expressing (Lgr5 + ) cells have been identified as stem/progenitor cells in the circumvallate…”
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