Search Results - "Zavascki, Alexandre"

Misassignment of patients in meta-analysis of polymyxin B by Zavascki, Alexandre P.

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Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B? by Zavascki, Alexandre P, Nation, Roger L

“…Nephrotoxicity is a common adverse effect of the clinically used polymyxins, colistin and polymyxin B. This adverse effect is dose limiting for both…”
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Urgent need for evaluation of point-of-care tests as an RT-PCR-sparing strategy for the diagnosis of Covid-19 in symptomatic patients by Zavascki, Alexandre P

“…The reverse transcriptase-polymerase chain reaction (RT-PCR) technique has been the gold standard for the diagnosis of Covid-19. In countries such as Brazil,…”
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Combination therapy with polymyxin B for carbapenemase-producing Klebsiella pneumoniae bloodstream infection by Medeiros, Gregory Saraiva, Rigatto, Maria Helena, Falci, Diego Rodrigues, Zavascki, Alexandre P.

“…•Combination therapy has been related to lower mortality in carbapenem-resistant K. pneumoniae BSIs, mostly with colistin.•There is a paucity of studies on…”
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International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP) by Tsuji, Brian T., Pogue, Jason M., Zavascki, Alexandre P., Paul, Mical, Daikos, George L., Forrest, Alan, Giacobbe, Daniele R., Viscoli, Claudio, Giamarellou, Helen, Karaiskos, Ilias, Kaye, Donald, Mouton, Johan W., Tam, Vincent H., Thamlikitkul, Visanu, Wunderink, Richard G., Li, Jian, Nation, Roger L., Kaye, Keith S.

“…The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the 1950s and thus did not undergo contemporary drug development…”
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Colistin versus colistin plus meropenem for severe infections by Zavascki, Alexandre P

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Which trial do we need? One or two antimicrobials with anti-pseudomonal activity for the empirical treatment of ventilator-associated pneumonia due to Gram-negative bacteria by Yusuf, Erlangga, Zavascki, Alexandre P, Endeman, Henrik, Kalil, Andre C

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Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens by Sandri, Ana M., Landersdorfer, Cornelia B., Jacob, Jovan, Boniatti, Márcio M., Dalarosa, Micheline G., Falci, Diego R., Behle, Tainá F., Bordinhão, Rosaura C., Wang, Jiping, Forrest, Alan, Nation, Roger L., Li, Jian, Zavascki, Alexandre P.

“…Background. Polymyxin B is a last-line therapy for multidrug-resistant gram-negative bacteria. There is a dearth of pharmacokinetic data to guide dosing in…”
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Polymyxin Acute Kidney Injury: Dosing and Other Strategies to Reduce Toxicity by Nation, Roger L, Rigatto, Maria Helena P, Falci, Diego R, Zavascki, Alexandre P

“…Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-negative bacteria; however, nephrotoxicity associated with these drugs is…”
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Clinical Characteristics of Covid-19 in China by Zavascki, Alexandre P, Falci, Diego R, Chen, Andre T.C, Coura-Filho, George B, Rehder, Marília H.H, Rolf, J. Douglass, Henry, Brandon M, Vikse, Jens, Guan, Wei-jie, Zhong, Nan-shan

“…To the Editor: According to the World Health Organization (WHO), the case definition for surveillance of returning travelers requires that they need to present…”
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Double-, single- and none-carbapenem-containing regimens for the treatment of carbapenem-resistant Enterobacterales (CRE) bloodstream infections: a retrospective cohort by Rigatto, Maria Helena, Ramos, Fabiano, Barros, Andressa, Pedroso, Silvia, Guasso, Isabelli, Gonçalves, Luciana, Bergo, Pedro, Zavascki, Alexandre P

“…OBJECTIVESTo investigate the effect of double-, single- and none-carbapenem-containing antimicrobial regimens in the treatment of patients with…”
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Can ceftolozane–tazobactam treat nosocomial pneumonia? by Kalil, Andre C, Zavascki, Alexandre P

“…Plasma concentrations above the MIC for 40% to 50% of the dosing interval were associated with a 2-log reduction of P aeruginosa in a thigh infection model.6…”
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Combination therapy for carbapenem-resistant Gram-negative bacteria by Zavascki, Alexandre P, Bulitta, Jurgen B, Landersdorfer, Cornelia B

“…The emergence of resistant to carbapenems Gram-negative bacteria (CR GNB) has severely challenged antimicrobial therapy. Many CR GNB isolates are only…”
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Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients by Zavascki, Alexandre P., Goldani, Luciano Z., Cao, Guoying, Superti, Silvana V., Lutz, Larissa, Barth, Afonso L., Ramos, Fabiano, Boniatti, Márcio M., Nation, Roger L., Li, Jian

“…Background. Although not much pharmacokinetic knowledge is available, polymyxin B is increasingly used for treatment of infections caused by gram-negative…”
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Risk factors for acute kidney injury in patients treated with polymyxin B or colistin methanesulfonate sodium by Tuon, Felipe F, Rigatto, Maria Helena, Lopes, Cesar K, Kamei, Letícia K, Rocha, Jaime L, Zavascki, Alexandre P

“…Abstract Polymyxin B (PMB) and colistin, administered as the prodrug colistin methanesulfonate sodium (CMS), are increasingly used to treat…”
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Substantial Diversity in Cocirculating Omicron Lineages in Hospital Setting, Porto Alegre, Brazil by Andreis, Tiago F, Cantarelli, Vlademir V, da Silva, Marcelo B, Helfer, Mateus S, Brust, Flavia R, Zavascki, Alexandre P

“…We describe substantial variant diversity among 23 detected SARS-CoV-2 Omicron lineage viruses cocirculating among healthcare workers and inpatients (272…”
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Severe Infusion-Related Adverse Events and Renal Failure in Patients Receiving High-Dose Intravenous Polymyxin B by John, Josiane F, Falci, Diego R, Rigatto, Maria Helena, Oliveira, Renata D, Kremer, Thaysa G, Zavascki, Alexandre P

“…The use of very high doses of polymyxin B (PMB) against carbapenem-resistant Gram-negative bacilli has been addressed in experiments as a strategy to improve…”
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Multicenter Prospective Cohort Study of Renal Failure in Patients Treated with Colistin versus Polymyxin B by Rigatto, Maria Helena, Oliveira, Maura S, Perdigão-Neto, Lauro V, Levin, Anna S, Carrilho, Claudia M, Tanita, Marcos Toshiyuki, Tuon, Felipe F, Cardoso, Douglas E, Lopes, Natane T, Falci, Diego R, Zavascki, Alexandre P

“…Nephrotoxicity is the main adverse effect of colistin and polymyxin B (PMB). It is not clear whether these two antibiotics are associated with different…”
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Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review by Zavascki, Alexandre Prehn, Goldani, Luciano Zubaran, Li, Jian, Nation, Roger L.

“…Polymyxins have re-emerged in clinical practice owing to the dry antibiotic development pipeline and worldwide increasing prevalence of nosocomial infections…”
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Comparison of vancomycin assays in patients undergoing hemodialysis by Scribel, Letícia, Galiotto, Aline, Rodrigues, Isadora de Souza, Hahn, Roberta, Linden, Rafael, Zavascki, Alexandre P.

“…Vancomycin is a glycopeptide antibiotic mainly excreted by glomerular filtration. Therefore, patients undergoing hemodialysis tend to accumulate its…”
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