Search Results - "Zautke, Nathan A."

Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O, Parkhill, Eric Q, Vasilevich, Natalya I, Glushkov, Andrei I, Zilbershtein, Timur M, Ivanov, Alexei V, Cole, Andrew G, Henderson, Ian, Zautke, Nathan A, Brunn, Sandra A, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W, Zablocki, Jeff

“…We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the…”
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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
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Resuscitation with lactated Ringer's does not increase inflammatory response in a swine model of uncontrolled hemorrhagic shock by WATTERS, Jennifer M, BRUNDAGE, Susan I, TODD, S. Rob, ZAUTKE, Nathan A, STEFATER, J. A, LAM, J. C, MULLER, Patrick J, MALINOSKI, Darren, SCHREIBER, Martin A

“…Lactated Ringer's (LR) and normal saline (NS) are widely and interchangeably used for resuscitation of trauma victims. Studies show LR to be superior to NS in…”
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Insulin Increases the Release of Proinflammatory Mediators by Brundage, Susan I., Kirilcuk, Natalie N., Lam, Jason C., Spain, David A., Zautke, Nathan A.

“…BACKGROUND:Strict glucose control with insulin is associated with decreased mortality in a mixed patient population in the intensive care unit. Controversy…”
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RESUSCITATION WITH LACTATED RINGER???S DOES NOT INCREASE INFLAMMATORY RESPONSE IN A SWINE MODEL OF UNCONTROLLED HEMORRHAGIC SHOCK by Watters, Jennifer M, Brundage, Susan I, Todd, S Rob, Zautke, Nathan A, Stefater, J A, Lam, J C, Muller, Patrick J, Malinoski, Darren, Schreiber, Martin A

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Novel, potent, selective, and metabolically stable stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, PARKHILL, Eric Q, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, VASILEVICH, Natalya I, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, IVANOV, Alexei V, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A, BRUNN, Sandra A

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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, VASILEVICH, Natalya I, BRUNN, Sandra A, CHU, Nancy, JIA HAO, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, PARKHILL, Eric Q, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, MAYBORODA, Elena I, BOZE, Melanie A, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A

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INSULIN INCREASES THE RELEASE OF PRO-INFLAMMATORY MEDIATORS by Brundage, Susan I., Zautke, Nathan A., Lam, Jason C., Dicker, Rochelle A., Spain, David A.

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