Search Results - "Zatsepin, T S"

mRNA-based therapeutics–Advances and perspectives by Sergeeva, O. V., Koteliansky, V. E., Zatsepin, T. S.

“…In this review we discuss features of mRNA synthesis and modifications used to minimize immune response and prolong efficiency of the translation process in…”
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Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents by Zatsepin, T S, Turner, J J, Oretskaya, T S, Gait, M J

“…The review describes key aspects of the synthesis and biological activities of conjugates of oligonucleotides and their analogues with synthetic peptides, in…”
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Modification of nucleic acids using [3 + 2]-dipolar cycloaddition of azides and alkynes by Ustinov, A. V, Stepanova, I. A, Dubnyakova, V. V, Zatsepin, T. S, Nozhevnikova, E. V, Korshun, V. A

“…The use of azide and alkyne cycloaddition reaction in the synthesis of conjugates of nucleic acids and oligodeoxyribonucleotides is reviewed. Data on the…”
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Integrator is a key component of human telomerase RNA biogenesis by Rubtsova, M. P., Vasilkova, D. P., Moshareva, M. A., Malyavko, A. N., Meerson, M. B., Zatsepin, T. S., Naraykina, Y. V., Beletsky, A. V., Ravin, N. V., Dontsova, O. A.

“…Telomeres are special DNA-protein structures that are located at the ends of linear eukaryotic chromosomes. The telomere length determines the proliferation…”
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Polymer/magnetite carriers functionalized by HER2-DARPin: Avoiding lysosomes during internalization and controlled toxicity of doxorubicin by focused ultrasound induced release by Novoselova, M.V., Shramova, E.I., Sergeeva, O.V., Shcherbinina, E.Y., Perevoschikov, S.V., Melnikov, P., Griaznova, O.Yu, Sergeev, I.S., Konovalova, E.V., Schulga, A.A., Proshkina, G.M., Zatsepin, T.S., Deyev, S.M., Gorin, D.A.

“…Nanomedicine has revolutionized the available treatment options during the last decade, but poor selectivity of targeted drug delivery and release is still…”
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Determination of the Affinity of Eukaryotic DDX3 RNA Helicase to the Characteristic Elements of mRNA Secondary Structure by Shikalov, A. B., Sergeeva, O. V., Zatsepin, T. S.

“…DDX3 RNA helicase is involved in many processes of RNA metabolism in eukaryotic cells. Many studies of DDX3 have shown that it is also involved in the…”
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Influence of Drug Resistance Mutations on the Activity of HIV-1 Subtypes A and B Integrases: a Comparative Study by Shadrina, O A, Zatsepin, T S, Agapkina, Yu Yu, Isaguliants, M G, Gottikh, M B

“…Integration of human immunodeficiency virus (HIV-1) DNA into the genome of an infected cell is one of the key steps in the viral replication cycle. The viral…”
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Expression of CASC8 RNA in Human Pancreatic Cancer Cell Lines by Burenina, O. Y., Lazarevich, N. L., Kustova, I. F., Zatsepin, T. S., Rubtsova, M. P., Dontsova, O. A.

“…A lot of long non-coding RNAs (lncRNAs) are expressed in human cells in a number of transcripts of different lengths and composition of exons. In case of…”
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Erratum to: Expression of CASC8 RNA in Human Pancreatic Cancer Cell Lines by Burenina, O. Y., Lazarevich, N. L., Kustova, I. F., Zatsepin, T. S., Rubtsova, M. P., Dontsova, O. A.

“…An Erratum to this paper has been published: https://doi.org/10.1134/S1607672955340012…”
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Design and Validation of siRNA Targeting Gankyrin in the Murine Liver by Prikazchikova, T. A., Abakumova, T. O., Sergeeva, O. V., Zatsepin, T. S.

“…— Despite recent success in the treatment of hepatocellular carcinoma and other liver cancers, development of new therapeutic approaches remains an unmet…”
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Activity of nsp14 Exonuclease from SARS-CoV-2 towards RNAs with Modified 3'-Termini by Yuyukina, S. K., Barmatov, A. E., Bizyaev, S. N., Stetsenko, D. A., Sergeeva, O. V., Zatsepin, T. S., Zharkov, D. O.

“…The COVID-19 pandemic has shown the urgent need for new treatments for coronavirus infections. Nucleoside analogs were successfully used to inhibit replication…”
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Template-Assisted Assembly of DNA Nanostructures from Branched Oligonucleotides by Fokina, A. A., Poletaeva, Yu. E., Burakova, E. A., Bakulina, A. Yu, Zatsepin, T. S., Ryabchikova, E. I., Stetsenko, D. A.

“…We have proposed previously a template-assisted method for 3D assembly of nucleic acid nanostructures. The method involved a branched oligonucleotide as a…”
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Long Noncoding RNA LL35/Falcor Regulates Expression of Transcription Factor Foxa2 in Hepatocytes in Normal and Fibrotic Mouse Liver by Sergeeva, O. V., Korinfskaya, S. A., Kurochkin, I. I., Zatsepin, T. S.

“…Long noncoding RNAs (lncRNA) play important roles in the regulation of transcription, splicing, translation, and other processes in the cell. Human and mouse…”
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Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver by Burenina, O. Y., Zatsepin, T. S., Kim, E. F., Metelin, A. V., Skvortsov, D. A., Rubtsova, M. P., Dontsova, O. A.

“…Long noncoding RNAs (lncRNAs) are promising biomarkers and potential targets for liver cancer therapy. Stable hepatocyte lines are used in vitro to investigate…”
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Oligonucleotide inhibitors of HIV-1 integrase efficiently inhibit HIV-1 reverse transcriptase by Korolev, S. P., Zatsepin, T. S., Gottikh, M. B.

“…The impact of conjugates of 11-mer 2′- О -methyl oligoribonucleotides with eosin and 6-carboxy-4,7,2′,4′,5′,7′-hexachlorofluorescein on the functioning of…”
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Design and Visualization of DNA/RNA Nanostructures from Branched Oligonucleotides Using Blender Software by Bakulina, A. Yu, Rad’kova, Z. V., Burakova, E. A., Benassi, E., Zatsepin, T. S., Fokina, A. A., Stetsenko, D. A.

“…Recently, three-dimensional nucleic acid nanostructures have attracted great interest, which have been made available through the DNA origami technique. We…”
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Synthesis of β-Diketone DNA Derivatives for Affinity Modification of Proteins by Monakhova, M. V., Kubareva, E. A., Romanova, E. A., Semkina, A. S., Naberezhnov, D. S., Rao, D. N., Zatsepin, T. S., Oretskaya, T. S.

“…Diketone DNA derivatives have been proposed to modify the guanidine group of Arg in proteins. The β-diketo group at the C2' atom of the sugar phosphate moiety…”
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Oligonucleotide inhibitors of telomerase: Prospects for anticancer therapy and diagnostics by Zvereva, M. I., Zatsepin, T. S., Azhibek, D. M., Shubernetskaya, O. S., Shpanchenko, O. V., Dontsova, O. A.

“…The activity of telomerase allows eukaryotic cells to have unlimited division potential. On its functioning, telomerase synthesizes short DNA repeats at the…”
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Affinity modification of the restriction endonuclease SsoII by 2'-aldehyde-containing double stranded DNAs by Sud'ina, A E, Zatsepin, T S, Pingoud, V, Pingoud, A, Oretskaya, T S, Kubareva, E A

“…Properties of 2'-aldehyde-containing double stranded DNAs (dsDNAs) have been studied for the first time as substrate analogs of the restriction endonuclease…”
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Analysis of DNA-Protein Interactions in Complexes of Transcription Factor NF-κB with DNA by Romanenkov, A. S., Ustyugov, A. A., Zatsepin, T. S., Nikulova, A. A., Kolesnikov, I. V., Metelev, V. G., Oretskaya, T. S., Kubareva, E. A.

“…We have applied bioinformatic analysis of X-ray 3D structures of complexes of transcription factor NF-κB with DNAs. We determined the number of possible Van…”
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