Search Results - "Zarzycka, Weronika"
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Age and Sex Differences in Heart Failure With Preserved Ejection Fraction
Published in Frontiers in aging (15-02-2022)“…Heart failure with preserved ejection fraction (HFpEF) is a multi-organ disorder that represents about 50% of total heart failure (HF) cases and is the most…”
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Modular self-assembly system for development of oligomeric, highly internalizing and potent cytotoxic conjugates targeting fibroblast growth factor receptors
Published in Journal of biomedical science (11-10-2021)“…Background Overexpression of FGFR1 is observed in numerous tumors and therefore this receptor constitutes an attractive molecular target for selective cancer…”
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FGF1 Fusions with the Fc Fragment of IgG1 for the Assembly of GFPpolygons-Mediated Multivalent Complexes Recognizing FGFRs
Published in Biomolecules (Basel, Switzerland) (23-07-2021)“…FGFRs are cell surface receptors that, when activated by specific FGFs ligands, transmit signals through the plasma membrane, regulating key cellular processes…”
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Emerging interactions between mitochondria and NAD+ metabolism in cardiometabolic diseases
Published in Trends in endocrinology and metabolism (27-08-2024)“…NAD+ is a coenzyme regulating cellular and mitochondrial metabolic processes and signaling.Reduced NAD+ levels and NAD+/NADH ratio have been observed in…”
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Abstract Mo107: Age-Related Impairment of Mitochondrial Protein Turnover Exacerbates Pathogenesis of Heart Failure with Preserved Ejection Fraction in Old Mice
Published in Circulation research (02-08-2024)“…Abstract only Introduction: Age is recognized as a major risk factor for heart failure with preserved ejection fraction (HFpEF), yet the precise role of aging…”
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Abstract P2088: Proteostatic Imbalance In Heart Failure With Preserved Ejection Fraction Is Accompanied By Mechanistic Target Of Rapamycin Complex 1 Hyperactivation
Published in Circulation research (04-08-2023)“…Abstract only Heart failure with preserved ejection fraction (HFpEF) is a multi-organ syndrome that represents approximately 50% of all heart failure (HF)…”
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Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging
Published in GeroScience (09-10-2024)“…The mechanistic target of rapamycin complex 1 (mTORC1) has a major impact on aging by regulation of proteostasis. It is well established that mTORC1 signaling…”
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