Search Results - "Zarytova, Valentina F."

High antiviral effect of TiO2·PL–DNA nanocomposites targeted to conservative regions of (−)RNA and (+)RNA of influenza A virus in cell culture by Levina, Asya S, Repkova, Marina N, Bessudnova, Elena V, Filippova, Ekaterina I, Mazurkova, Natalia A, Zarytova, Valentina F

“…Summary Background: The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most…”
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Non-agglomerated silicon-organic nanoparticles and their nanocomplexes with oligonucleotides: synthesis and properties by Levina, Asya S, Repkova, Marina N, Shikina, Nadezhda V, Ismagilov, Zinfer R, Yashnik, Svetlana A, Semenov, Dmitrii V, Savinovskaya, Yulia I, Mazurkova, Natalia A, Pyshnaya, Inna A, Zarytova, Valentina F

“…The development of efficient and convenient systems for the delivery of nucleic-acid-based drugs into cells is an urgent task. А promising approach is the use…”
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Substantial Antiviral Potential of Deoxyribozymes Fixed on Anatase Nanoparticles Against Influenza A Viruses in vitro and in vivo by Levina, Asya S, Repkova, Marina N, Netesova, Nina A, Ternovoi, Vladimir A, Mazurkov, Oleg Yu, Filippova, Ekaterina I, Mazurkova, Natalia A, Zarytova, Valentina F

“…Influenza A viruses (IAV) are a high threat to humanity because of a lack of proper effective antiviral drugs and resistance of viruses to existing vaccines…”
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Knockdown of different influenza A virus subtypes in cell culture by a single antisense oligodeoxyribonucleotide by Levina, Asya S, Repkova, Marina N, Mazurkova, Natalia A, Makarevich, Elena V, Ismagilov, Zinfer R, Zarytova, Valentina F

“…Highlights • A single oligonucleotide efficiently inhibited various influenza A virus (IAV) strains. • Oligonucleotide is delivered into cells in a TiO2…”
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Nanocomposites consisting of titanium dioxide nanoparticles, antisense oligonucleotides, and photoactive groups as agents for effective action on nucleic acids by Levina, Asya S., Repkova, Marina N., Mazurkov, Oleg Y., Makarevich, Elena V., Mazurkova, Natalya A., Zarytova, Valentina F.

“…Relevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the…”
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Nanoparticle-Mediated Nonviral DNA Delivery for Effective Inhibition of Influenza a Viruses in Cells by Levina, Asya S., Repkova, Marina N., Mazurkova, Natalia A., Zarytova, Valentina F.

“…Development of new antiviral nucleic acid-based drugs and the search for their efficient delivery into cells are an urgent task. We prepared the TiO2·PL-DNA…”
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SiO2 nanoparticles as platform for delivery of 3′-triazole analogues of AZT-triphosphate into cells by Vasilyeva, Svetlana V., Levina, Asya S., Li-Zhulanov, Nikolai S., Shatskaya, Natalia V., Baiborodin, Sergei I., Repkova, Marina N., Zarytova, Valentina F., Mazurkova, Natalia A., Silnikov, Vladimir N.

“…[Display omitted] A system for delivery of analogues of AZT-triphosphates (AZT*TP) based on SiO2 nanoparticles was proposed. For this purpose, a simple and…”
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High-performance method for specific effect on nucleic acids in cells using TiO2~DNA nanocomposites by Levina, Asya S., Repkova, Marina N., Ismagilov, Zinfer R., Shikina, Nadezhda V., Malygin, Ernst G., Mazurkova, Natalia A., Zinov'ev, Victor V., Evdokimov, Alexei A., Baiborodin, Sergei I., Zarytova, Valentina F.

“…Nanoparticles are used to solve the current drug delivery problem. We present a high-performance method for efficient and selective action on nucleic acid…”
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SiO2 nanoparticles as platform for delivery of nucleoside triphosphate analogues into cells by Vasilyeva, Svetlana V., Silnikov, Vladimir N., Shatskaya, Natalia V., Levina, Asya S., Repkova, Marina N., Zarytova, Valentina F.

“…A system for delivery of analogues of 2′-deoxyribonucleoside triphosphate (dNTP) based on SiO2 nanoparticles was proposed. A simple and versatile method was…”
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Short Oligonucleotide Tandem Ligation Assay for Genotyping of Single-Nucleotide Polymorphisms in Y Chromosome by Skobeltsyna, Larisa M, Pyshnyi, Dmitrii V, Ivanova, Eugenia M, Stepanov, Vadim A, Puzyrev, Valery P, Dymshits, Grigory M, Kharkov, Vladimir N, Zarytova, Valentina F

“…We propose a novel universal methodology, Short Oligonucleotide Tandem Ligation Assay (SOTLA), for SNP genotyping. SOTLA is based on using a tandem of short…”
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Site-Specific Cleavage of RNA and DNA by Complementary DNA−Bleomycin A5 Conjugates by Vorobjev, Pavel E, Smith, Janet B, Pyshnaya, Inna A, Levina, Asya S, Zarytova, Valentina F, Wickstrom, Eric

“…Bleomycin displays clinical chemotherapeutic activity, but is so nonspecifically toxic that it is rarely administered. It was therefore of interest to…”
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The Influence of the Non-Nucleotide Insert on the Hybridization Properties of Oligonucleotides by Pyshnaya, Inna A., Pyshnyi, Dmitrii V., Lomzov, Alexander A., Zarytova, Valentina F., Ivanova, Eugenia M.

“…The effect of different non-nucleotide inserts incorporated into oligonucleotide chains on their hybridization properties was studied by the method of thermal…”
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High antiviral effect of TiO 2 ·PL-DNA nanocomposites targeted to conservative regions of (-)RNA and (+)RNA of influenza A virus in cell culture by Levina, Asya S, Repkova, Marina N, Bessudnova, Elena V, Filippova, Ekaterina I, Mazurkova, Natalia A, Zarytova, Valentina F

“…The development of new antiviral drugs based on nucleic acids is under scrutiny. An important problem in this aspect is to find the most vulnerable…”
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Synthesis of bleomycin A5 oligonucleotide derivatives and site-specific cleavage of the DNA target by Zarytova, Valentina F, Sergeyev, Dmitrij S, Godovikova, Tatjana S

“…A method for coupling bleomycin A5 to oligonucleotides is proposed. The reaction was carried out between an amino group of a spermidine residue of the Cu(II)…”
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Mechanism of Oligonucleotide Uptake by Cells: Involvement of Specific receptors? by Yakubov, Leonid A., Deeva, Elena A., Zarytova, Valentina F., Ivanova, Eugenia M., Ryte, Antonina S., Yurchenko, Lyudmila V., Vlassov, Valentin V.

“…We have investigated the interaction of oligonucleotides and their alkylating derivatives with mammalian cells. In experiments with L929 mouse fibroblast and…”
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Short Oligonucleotide Tandem Ligation Assay for Genotyping of Single-Nucleotide Polymorphisms in Y Chromosome by SKOBELTSYNA, Larisa M, PYSHNYI, Dmitrii V, IVANOVA, Eugenia M, STEPANOV, Vadim A, PUZYREV, Valery P, DYMSHITS, Grigory M, KHARKOV, Vladimir N, ZARYTOVA, Valentina F

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TiO2∼DNA nanocomposites as efficient site-specific antiviral agents against influenza A virus in cell culture by Levina, Asya S., Repkova, Marina N., Zarytova, Valentina F., Mazurkova, Natalia A.

“…The development of new antiviral nucleic acid-based drugs and the search for their efficient delivery into cells are an urgent task. We developed methods of…”
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Thermodynamic Analysis of Stacking Hybridization of Oligonucleotides with DNA Template by Pyshnyi, Dmitrii V., Pyshnaya, Inna A., Levina, Asya S., Goldberg, Eugenii L., Zarytova, Valentina F., Knorre, Dmitrii G., Ivanova, Eugenia M.

“…Contiguous stacking hybridization of oligodeoxyribonucleotides with DNA as template was investigated using three types of complexes: oligonucleotide…”
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Catalytic site-specific cleavage of a DNA-target by an oligonucleotide carrying bleomycin A5 by Sergeyev, Dmity S., Godovikova, Tatjana S., Zarytova, Valentina F.

“…Oligonucleotide reagents have been created which are capable of catalytic site-specific cleavage of DNAtargets. The oligonucleotide reagent Blm-R-pd(CCAAACA)…”
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Sequence-specific chemical modification of double-stranded DNA with alkylating oligodeoxyribonucleotide derivatives by Vlassov, V V, Gaidamakov, S A, Zarytova, V F, Knorre, D G, Levina, A S, Nikonova, A A, Podust, L M, Fedorova, O S

“…Chemical modification of double-stranded (ds) DNA with alkylating oligodeoxynucleotide (oligo) derivatives, 5'-p(N-2-chloroethyl-N-methylamino) benzylamides of…”
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