Search Results - "Zartman, Jeremiah J"

Coordination of Patterning and Growth by the Morphogen DPP by Restrepo, Simon, Zartman, Jeremiah J., Basler, Konrad

“…The elegance of animal body plans derives from an intimate connection between function and form, which during organ formation is linked to patterning and…”
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From spikes to intercellular waves: Tuning intercellular calcium signaling dynamics modulates organ size control by Soundarrajan, Dharsan K, Huizar, Francisco J, Paravitorghabeh, Ramezan, Robinett, Trent, Zartman, Jeremiah J

“…Information flow within and between cells depends significantly on calcium (Ca2+) signaling dynamics. However, the biophysical mechanisms that govern emergent…”
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Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix by Nematbakhsh, Ali, Levis, Megan, Kumar, Nilay, Chen, Weitao, Zartman, Jeremiah J, Alber, Mark

“…Epithelial sheets define organ architecture during development. Here, we employed an iterative multiscale computational modeling and quantitative experimental…”
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Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development by Kumar, Nilay, Rangel Ambriz, Jennifer, Tsai, Kevin, Mim, Mayesha Sahir, Flores-Flores, Marycruz, Chen, Weitao, Zartman, Jeremiah J., Alber, Mark

“…How a developing organ robustly coordinates the cellular mechanics and growth to reach a final size and shape remains poorly understood. Through iterations…”
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Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth by Howe, Erin N., Burnette, Miranda D., Justice, Melanie E., Schnepp, Patricia M., Hedrick, Victoria, Clancy, James W., Guldner, Ian H., Lamere, Alicia T., Li, Jun, Aryal, Uma K., D’Souza-Schorey, Crislyn, Zartman, Jeremiah J., Zhang, Siyuan

“…Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation to the brain…”
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Piezo regulates epithelial topology and promotes precision in organ size control by Mim, Mayesha Sahir, Kumar, Nilay, Levis, Megan, Unger, Maria F., Miranda, Gabriel, Gazzo, David, Robinett, Trent, Zartman, Jeremiah J.

“…Mechanosensitive Piezo channels regulate cell division, cell extrusion, and cell death. However, systems-level functions of Piezo in regulating organogenesis…”
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Capabilities and Limitations of Tissue Size Control through Passive Mechanical Forces by Kursawe, Jochen, Brodskiy, Pavel A, Zartman, Jeremiah J, Baker, Ruth E, Fletcher, Alexander G

“…Embryogenesis is an extraordinarily robust process, exhibiting the ability to control tissue size and repair patterning defects in the face of environmental…”
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Reverse engineering morphogenesis through Bayesian optimization of physics-based models by Kumar, Nilay, Mim, Mayesha Sahir, Dowling, Alexander, Zartman, Jeremiah J.

“…Morphogenetic programs coordinate cell signaling and mechanical interactions to shape organs. In systems and synthetic biology, a key challenge is determining…”
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Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia by Nematbakhsh, Ali, Sun, Wenzhao, Brodskiy, Pavel A, Amiri, Aboutaleb, Narciso, Cody, Xu, Zhiliang, Zartman, Jeremiah J, Alber, Mark

“…Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an abnormal number of chromosomes, a condition that occurs…”
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Preclinical study of a Kv11.1 potassium channel activator as antineoplastic approach for breast cancer by Fukushiro-Lopes, Daniela F, Hegel, Alexandra D, Rao, Vidhya, Wyatt, Debra, Baker, Andrew, Breuer, Eun-Kyoung, Osipo, Clodia, Zartman, Jeremiah J, Burnette, Miranda, Kaja, Simon, Kouzoukas, Dimitrios, Burris, Sarah, Jones, W Keith, Gentile, Saverio

“…Potassium ion (K ) channels have been recently found to play a critical role in cancer biology. Despite that pharmacologic manipulation of ion channels is…”
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Tools to reverse-engineer multicellular systems: case studies using the fruit fly by Wu, Qinfeng, Kumar, Nilay, Velagala, Vijay, Zartman, Jeremiah J

“…Reverse-engineering how complex multicellular systems develop and function is a grand challenge for systems bioengineers. This challenge has motivated the…”
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MAPPER: An Open-Source, High-Dimensional Image Analysis Pipeline Unmasks Differential Regulation of Drosophila Wing Features by Kumar, Nilay, Huizar, Francisco J, Farfán-Pira, Keity J, Brodskiy, Pavel A, Soundarrajan, Dharsan K, Nahmad, Marcos, Zartman, Jeremiah J

“…Phenomics requires quantification of large volumes of image data, necessitating high throughput image processing approaches. Existing image processing…”
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Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis by Zartman, Jeremiah J, Kanodia, Jitendra S, Cheung, Lily S, Shvartsman, Stanislav Y

“…The morphogenesis of structures with repeated functional units, such as body segments and appendages, depends on multi-domain patterns of cell signaling and…”
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Pinching and pushing: fold formation in the Drosophila dorsal epidermis by Velagala, Vijay, Zartman, Jeremiah J.

“…Epithelial folding is a fundamental morphogenetic process that shapes planar epithelial sheets into complex three-dimensional structures. Multiple mechanisms…”
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Proteins clump: Mechanics and transport during neurodegeneration by Gazzo, David, Kinzer-Ursem, Tamara L, Zartman, Jeremiah J

“…This summary of recent contributions in the Biophysical Journal from 2020 to 2023 highlights new mechanistic insights into key biomechanical and biophysical…”
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Sizing it up: The mechanical feedback hypothesis of organ growth regulation by Buchmann, Amy, Alber, Mark, Zartman, Jeremiah J.

“…•Mechanical feedback is reviewed as a mechanism that regulates the final size of organs.•Models combining intercellular signaling and biomechanics can explain…”
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Linking chemical signaling to mechanical components to determine tissue shape in the Drosophila wing imaginal disc by Toomey, Alysha, Kumar, Nilay, Mim, Mayesha S., Alber, Mark, Chen, Weitao, Zartman, Jeremiah J.

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Low-cost Polyethylene Terephthalate Lamination Microfluidics Designs for Multiplexed Zebrafish Imaging by Tan, Shelly, Zhu, Xiaoguang, Zartman, Jeremiah J, Deng, Qing

“…Zebrafish embryos are transparent and thus uniquely suited for noninvasive intravital imaging of fundamental processes, such as wound healing and immune cell…”
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Quantitative insights in tissue growth and morphogenesis with optogenetics by Mim, Mayesha Sahir, Knight, Caroline, Zartman, Jeremiah J

“…Cells communicate with each other to jointly regulate cellular processes during cellular differentiation and tissue morphogenesis. This multiscale coordination…”
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Modeling study of the impact of actomyosin contractility on cell proliferation in the Drosophila wing imaginal disc by Ambriz, Jennifer Rangel, Kumar, Nilay, Tsai, Kevin, Mim, Mayesha S., Chen, Weitao, Zartman, Jeremiah J., Alber, Mark

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