Search Results - "Zaro, Balyn W."

EMC chaperone–CaV structure reveals an ion channel assembly intermediate by Chen, Zhou, Mondal, Abhisek, Abderemane-Ali, Fayal, Jang, Seil, Niranjan, Sangeeta, Montaño, José L., Zaro, Balyn W., Minor, Daniel L.

“…Voltage-gated ion channels (VGICs) comprise multiple structural units, the assembly of which is required for function 1 , 2 . Structural understanding of how…”
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Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1 by Zaro, Balyn W, Yang, Yu-Ying, Hang, Howard C, Pratt, Matthew R

“…The dynamic modification of nuclear and cytoplasmic proteins by the monosaccharide N-acetyl-glucosamine (GlcNAc) continues to emerge as an important regulator…”
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The Proteome‐Wide Potential for Reversible Covalency at Cysteine by Senkane, Kristine, Vinogradova, Ekaterina V., Suciu, Radu M., Crowley, Vincent M., Zaro, Balyn W., Bradshaw, J. Michael, Brameld, Ken A., Cravatt, Benjamin F.

“…Reversible covalency, achieved with, for instance, highly electron‐deficient olefins, offers a compelling strategy to design chemical probes and drugs that…”
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Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy by Gurel, Zafer, Zaro, Balyn W, Pratt, Matthew R, Sheibani, Nader

“…Hyperglycemia is the primary cause of the majority of diabetes complications, including diabetic retinopathy (DR). Hyperglycemic conditions have a detrimental…”
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An Alkyne–Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells by Bateman, Leslie A, Zaro, Balyn W, Miller, Stephanie M, Pratt, Matthew R

“…Aspirin (acetylsalicylic acid) is widely used for the acute treatment of inflammation and the management of cardiovascular disease. More recently, it has also…”
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Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells by Zaro, Balyn W, Noh, Joseph J, Mascetti, Victoria L, Demeter, Janos, George, Benson, Zukowska, Monika, Gulati, Gunsagar S, Sinha, Rahul, Flynn, Ryan A, Banuelos, Allison, Zhang, Allison, Wilkinson, Adam C, Jackson, Peter, Weissman, Irving L

“…The balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a healthy blood supply; imbalances underlie hematological…”
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MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes by Datta, Ritwik, Gholampour, Mohammad A., Yang, Christopher D., Volk, Regan, Lin, Sinan, Podolsky, Michael J., Arnold, Thomas, Rieder, Florian, Zaro, Balyn W., Verzi, Michael, Lehner, Richard, Abumrad, Nada, Lizama, Carlos O., Atabai, Kamran

“…Enterocytes modulate the extent of postprandial lipemia by storing dietary fats in cytoplasmic lipid droplets (cLDs). We have previously shown that the…”
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Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission by Sapiro, Anne L, Hayes, Beth M, Volk, Regan F, Zhang, Jenny Y, Brooks, Diane M, Martyn, Calla, Radkov, Atanas, Zhao, Ziyi, Kinnersley, Margie, Secor, Patrick R, Zaro, Balyn W, Chou, Seemay

“…( ), the causative agent of Lyme disease, adapts to vastly different environments as it cycles between tick vector and vertebrate host. During a tick…”
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Chemical Reporter for Visualizing Metabolic Cross-Talk between Carbohydrate Metabolism and Protein Modification by Zaro, Balyn W, Chuh, Kelly N, Pratt, Matthew R

“…Metabolic chemical reporters have been largely used to study posttranslational modifications. Generally, it was assumed that these reporters entered one…”
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O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins by Darabedian, Narek, Yang, Bo, Ding, Richie, Cutolo, Giuliano, Zaro, Balyn W, Woo, Christina M, Pratt, Matthew R

“…Monosaccharide analogs bearing bioorthogonal functionalities, or metabolic chemical reporters (MCRs) of glycosylation, have been used for approximately two…”
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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy by Barkal, Amira A., Brewer, Rachel E., Markovic, Maxim, Kowarsky, Mark, Barkal, Sammy A., Zaro, Balyn W., Krishnan, Venkatesh, Hatakeyama, Jason, Dorigo, Oliver, Barkal, Layla J., Weissman, Irving L.

“…Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis…”
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Precise Control of Protein Concentration in Living Cells by Lau, Hubert D, Yaegashi, Junko, Zaro, Balyn W, Pratt, Matthew R

“…Rapamycin to the rescue: Native protein concentration was precisely controlled in living cells by using the small molecule rapamycin. The addition of rapamycin…”
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Secreted fungal virulence effector triggers allergic inflammation via TLR4 by Dang, Eric V., Lei, Susan, Radkov, Atanas, Volk, Regan F., Zaro, Balyn W., Madhani, Hiten D.

“…Invasive fungal pathogens are major causes of human mortality and morbidity 1 , 2 . Although numerous secreted effector proteins that reprogram innate immunity…”
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Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells by Blewett, Megan M, Xie, Jiji, Zaro, Balyn W, Backus, Keriann M, Altman, Amnon, Teijaro, John R, Cravatt, Benjamin F

“…Dimethyl fumarate (DMF) is an electrophilic drug that is used to treat autoimmune conditions, including multiple sclerosis and psoriasis. The mechanism of…”
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Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O‑GlcNAc Modification by Chuh, Kelly N, Zaro, Balyn W, Piller, Friedrich, Piller, Véronique, Pratt, Matthew R

“…Metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides that contain bioorthogonal functionalities and enable the direct…”
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O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease by Marotta, Nicholas P., Lin, Yu Hsuan, Lewis, Yuka E., Ambroso, Mark R., Zaro, Balyn W., Roth, Maxwell T., Arnold, Don B., Langen, Ralf, Pratt, Matthew R.

“…Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N -acetyl-glucosamine (O-GlcNAc) in vivo . One of…”
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Correction to “Changes in Metabolic Chemical Reporter Structure Yield a Selective Probe of O‑GlcNAc Modification” by Chuh, Kelly N., Zaro, Balyn W., Piller, Friedrich, Piller, Véronique, Pratt, Matthew R.

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The New Chemical Reporter 6‑Alkynyl-6-deoxy-GlcNAc Reveals O‑GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase‑8 by Chuh, Kelly N, Batt, Anna R, Zaro, Balyn W, Darabedian, Narek, Marotta, Nicholas P, Brennan, Caroline K, Amirhekmat, Arya, Pratt, Matthew R

“…O-GlcNAc modification (O-GlcNAcylation) is required for survival in mammalian cells. Genetic and biochemical experiments have found that increased modification…”
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Refinement of covalent EGFR inhibitor AZD9291 to eliminate off-target activity by Bouffard, Elise, Zaro, Balyn W., Dix, Melissa M., Cravatt, Benjamin, Wong, Chi-Huey

“…[Display omitted] •Off-target activity of EGFR tyrosine kinase inhibitor AZD9291.•Chemical proteomic analysis of AZD9291 analogs.•Reduction of off-target…”
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Metabolically Labile Fumarate Esters Impart Kinetic Selectivity to Irreversible Inhibitors by Zaro, Balyn W, Whitby, Landon R, Lum, Kenneth M, Cravatt, Benjamin F

“…Electrophilic small molecules are an important class of chemical probes and drugs that produce biological effects by irreversibly modifying proteins. Examples…”
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