Search Results - "Zarkower, David"

Identification of sex‐specific molecular markers using restriction site‐associated DNA sequencing by Gamble, Tony, Zarkower, David

“…A major barrier to evolutionary studies of sex determination and sex chromosomes has been a lack of information on the types of sex‐determining mechanisms that…”
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DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment by Zhang, Teng, Oatley, Jon, Bardwell, Vivian J, Zarkower, David

“…Male mammals produce sperm for most of postnatal life and therefore require a robust germ line stem cell system, with precise balance between self-renewal and…”
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Establishing sexual dimorphism: conservation amidst diversity? by Zarkower, David

“…The molecular mechanisms that control sexual dimorphism are very different in distantly related animals. Did sex determination arise several times with…”
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Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads by Lambeth, Luke S., Raymond, Christopher S., Roeszler, Kelly N., Kuroiwa, Asato, Nakata, Tomohiro, Zarkower, David, Smith, Craig A.

“…DMRT1 encodes a conserved transcription factor with an essential role in gonadal function. In the chicken, DMRT1 in located on the Z sex chromosome and is…”
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Temporal changes of Sall4 lineage contribution in developing embryos and the contribution of Sall4-lineages to postnatal germ cells in mice by Tahara, Naoyuki, Kawakami, Hiroko, Zhang, Teng, Zarkower, David, Kawakami, Yasuhiko

“…Mutations in the SALL4 gene cause human syndromes with defects in multiple organs. Sall4 expression declines rapidly in post-gastrulation mouse embryos, and…”
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An ancient protein-DNA interaction underlying metazoan sex determination by Murphy, Mark W, Lee, John K, Rojo, Sandra, Gearhart, Micah D, Kurahashi, Kayo, Banerjee, Surajit, Loeuille, Guy-André, Bashamboo, Anu, McElreavey, Kenneth, Zarkower, David, Aihara, Hideki, Bardwell, Vivian J

“…DMRT transcription factors, key regulators of metazoan sexual development, use a unique DNA binding mode critical for male-to-female sex reversal in humans…”
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Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis by Agrimson, Kellie S, Minkina, Anna, Sadowski, Danielle, Wheeler, Andrew, Murphy, Mark W, Gearhart, Micah D, Bardwell, Vivian J, Zarkower, David

“…The mammalian nuclear hormone receptors LRH1 (NR5A2) and SF1 (NR5A1) are close paralogs that can bind the same DNA motif and play crucial roles in gonadal…”
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The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis by Zhang, Teng, Murphy, Mark W, Gearhart, Micah D, Bardwell, Vivian J, Zarkower, David

“…In mammals, a key transition in spermatogenesis is the exit from spermatogonial differentiation and mitotic proliferation and the entry into spermatocyte…”
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DMRT1 Protects Male Gonadal Cells from Retinoid-Dependent Sexual Transdifferentiation by Minkina, Anna, Matson, Clinton K., Lindeman, Robin E., Ghyselinck, Norbert B., Bardwell, Vivian J., Zarkower, David

“…Mammalian sex determination initiates in the fetal gonad with specification of bipotential precursor cells into male Sertoli cells or female granulosa cells…”
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Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation by Kim, Shinseog, Bardwell, Vivian J., Zarkower, David

“…Genes containing the DM domain, a conserved DNA binding motif first found in Doublesex of Drosophila and mab-3 of Caenorhabditis elegans, regulate sexual…”
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TRA-1 ChIP-seq reveals regulators of sexual differentiation and multilevel feedback in nematode sex determination by Berkseth, Matt, Ikegami, Kohta, Arur, Swathi, Lieb, Jason D., Zarkower, David

“…How sexual regulators translate global sexual fate into appropriate local sexual differentiation events is perhaps the least understood aspect of sexual…”
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DMRT proteins and coordination of mammalian spermatogenesis by Zhang, Teng, Zarkower, David

“…DMRT genes encode a deeply conserved family of transcription factors that share a unique DNA binding motif, the DM domain. DMRTs regulate development in a…”
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DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary by Krentz, Anthony D., Murphy, Mark W., Sarver, Aaron L., Griswold, Michael D., Bardwell, Vivian J., Zarkower, David

“…Dmrt1 belongs to the DM domain gene family of conserved sexual regulators. In the mouse Dmrt1 is expressed in the genital ridge (the gonadal primordium) in…”
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Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary by Minkina, Anna, Lindeman, Robin E., Gearhart, Micah D., Chassot, Anne-Amandine, Chaboissier, Marie-Christine, Ghyselinck, Norbert B., Bardwell, Vivian J., Zarkower, David

“…Retinoic acid (RA) is a potent inducer of cell differentiation and plays an essential role in sex-specific germ cell development in the mammalian gonad. RA is…”
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DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency by Krentz, Anthony D, Murphy, Mark W, Kim, Shinseog, Cook, Matthew S, Capel, Blanche, Zhu, Rui, Matin, Angabin, Sarver, Aaron L, Parker, Keith L, Griswold, Michael D, Looijenga, Leendert H.J, Bardwell, Vivian J, Zarkower, David

“…Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development…”
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DMRT1 prevents female reprogramming in the postnatal mammalian testis by MATSON, Clinton K, MURPHY, Mark W, SARVER, Aaron L, GRISWOLD, Michael D, BARDWELL, Vivian J, ZARKOWER, David

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Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis by Murphy, Mark W., Sarver, Aaron L., Rice, Daren, Hatzi, Katerina, Ye, Kenny, Melnick, Ari, Heckert, Leslie L., Zarkower, David, Bardwell, Vivian J., Kimble, Judith

“…The DM domain proteins Doublesex- and MAB-3–related transcription factors (DMRTs) are widely conserved in metazoan sex determination and sexual…”
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Etiology of Ovarian Failure in Blepharophimosis Ptosis Epicanthus Inversus Syndrome: FOXL2 Is a Conserved, Early-Acting Gene in Vertebrate Ovarian Development by Loffler, Kelly A, Zarkower, David, Koopman, Peter

“…Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused by mutations in the forkhead transcription factor gene FOXL2 and is…”
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Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line by Krentz, Anthony D., Murphy, Mark W., Zhang, Teng, Sarver, Aaron L., Jain, Sanjay, Griswold, Michael D., Bardwell, Vivian J., Zarkower, David

“…Dmrt1 (doublesex and mab-3 related transcription factor (1) is a regulator of testis development in vertebrates that has been implicated in testicular germ…”
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The doublesex homolog Dmrt5 is required for the development of the caudomedial cerebral cortex in mammals by Saulnier, Amandine, Keruzore, Marc, De Clercq, Sarah, Bar, Isabelle, Moers, Virginie, Magnani, Dario, Walcher, Tessa, Filippis, Carol, Kricha, Sadia, Parlier, Damien, Viviani, Laurène, Matson, Clinton K, Nakagawa, Yasushi, Theil, Thomas, Götz, Magdalena, Mallamaci, Antonello, Marine, Jean-Christophe, Zarkower, David, Bellefroid, Eric J

“…Regional patterning of the cerebral cortex is initiated by morphogens secreted by patterning centers that establish graded expression of transcription factors…”
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