HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis

The aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as...

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Published in:	Brazilian journal of medical and biological research Vol. 38; no. 5; pp. 767 - 775
Main Authors:	Lyra, A C, Pinho, J R R, Silva, L K, Sousa, L, Saraceni, C P, Braga, E L, Pereira, J E, Zarife, M A S, Reis, M G, Lyra, L G C, Silva, L C da, Carrilho, F J
Format:	Journal Article
Language:	English
Published:	Brazil Associação Brasileira de Divulgação Científica 01-05-2005
Subjects:	Acute Disease Acute hepatitis BIOLOGY Biomarkers Brazil Brazil - epidemiology Case-Control Studies Female GB virus C - genetics GB virus C - immunology GBV-C/HGV Genotype Hepatitis Antibodies - blood Hepatitis E Hepatitis E virus Hepatitis E virus - genetics Hepatitis E virus - immunology Hepatitis, Viral, Human - diagnosis Hepatitis, Viral, Human - epidemiology Hepatitis, Viral, Human - virology Humans Immunoglobulin G - blood Immunoglobulin M - blood Male MEDICINE, RESEARCH & EXPERIMENTAL Polymerase Chain Reaction Prevalence Sentinel Surveillance Severity of Illness Index Torque teno virus - genetics Torque teno virus - immunology TTV Brazil Brazil GBV-C/HGV Genotype Hepatitis E Acute hepatitis TTV
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Summary:	The aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as controls. IgM and anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial kits. TTV and GBV-C/HGV were detected by nested PCR; genotyping was done by sequencing and phylogenetic analysis. Anti-HEV IgG was present in 38, 10 and 17% of patients with hepatitis A, B and non-A-C. Four patients with hepatitis A and 1 with non-A-C hepatitis also had anti-HEV IgM detected in serum. TTV was detected in 21% of patients with acute hepatitis and in 31% of donors. GBV-C/HGV was detected in 9% of patients with hepatitis, and in 10% of donors. We found TTV isolates of genotypes 1, 2, 3, and 4 and GBV-C/HGV isolates of genotypes 1 and 2. Mean aminotransferase levels were lower in patients who were TTV or GBV-C/HGV positive. In conclusion, the detection of anti-HEV IgM in some acute hepatitis A cases suggests co-infection with HEV and hepatitis E could be the etiology of a few cases of sporadic non-A-C hepatitis in Salvador, Brazil. TTV genotype 1, 2, 3 and 4 isolates and GBV-C/HGV genotype 1 and 2 strains are frequent in the studied population. TTV and GBV-C/HGV infection does not appear to have a role in the etiology of acute hepatitis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0100-879X 1414-431X 0100-879X 1414-431X
DOI:	10.1590/S0100-879X2005000500015