Search Results - "Zaric, Violeta"

Investigating Immune Responses to the scAAV9-HEXM Gene Therapy Treatment in Tay–Sachs Disease and Sandhoff Disease Mouse Models by Kot, Shalini, Karumuthil-Melethil, Subha, Woodley, Evan, Zaric, Violeta, Thompson, Patrick, Chen, Zhilin, Lykken, Erik, Keimel, John G., Kaemmerer, William F., Gray, Steven J., Walia, Jagdeep S.

“…GM2 gangliosidosis disorders are a group of neurodegenerative diseases that result from a functional deficiency of the enzyme β-hexosaminidase A (HexA). HexA…”
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Muscarinic cholinergic receptor M1 in the rat basolateral amygdala: Ultrastructural localization and synaptic relationships to cholinergic axons by Muller, Jay F., Mascagni, Franco, Zaric, Violeta, McDonald, Alexander J.

“…Muscarinic neurotransmission in the anterior basolateral amygdalar nucleus (BLa) mediated by the M1 receptor (M1R) is critical for memory consolidation…”
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Subpopulations of somatostatin-immunoreactive non-pyramidal neurons in the amygdala and adjacent external capsule project to the basal forebrain: evidence for the existence of GABAergic projection neurons in the cortical nuclei and basolateral nuclear complex by McDonald, Alexander J, Mascagni, Franco, Zaric, Violeta

“…The hippocampus and amygdala are key structures of the limbic system whose connections include reciprocal interactions with the basal forebrain (BF). The…”
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Improved MECP2 Gene Therapy Extends the Survival of MeCP2-Null Mice without Apparent Toxicity after Intracisternal Delivery by Sinnett, Sarah E, Hector, Ralph D, Gadalla, Kamal K E, Heindel, Clifford, Chen, Daphne, Zaric, Violeta, Bailey, Mark E S, Cobb, Stuart R, Gray, Steven J

“…Intravenous administration of adeno-associated virus serotype 9 (AAV9)/ has been shown to extend the lifespan of mice, but this delivery route induces liver…”
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Inhibition of Endothelial Cell Proliferation by per-O-acetylated Mannose Conjugates by ZARIC, Violeta, DOYLE, Dearbhla, MURPHY, Paul V, O'BOYLE, Kathy M

“…Background: The inhibition of angiogenesis, defined as the process of new blood vessel formation, represents a promising strategy for treating cancer…”
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N-Glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types by Rawe, Sarah L., Doyle, Dearbhla, Zaric, Violeta, Rozas, Isabel, McMahon, Kevin, Tosin, Manuela, Bunz, Helge Müller, Murphy, Evelyn P., O’ Boyle, Kathy M., Murphy, Paul V.

“…A range of N-glycosyl-thiophene-2-carboxamides, including a 6 H-thieno[2,3- c]pyridin-7-one and a bivalent compound, have been synthesised and assayed for…”
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Serotype survey of AAV gene delivery via subconjunctival injection in mice by Song, Liujiang, Llanga, Telmo, Conatser, Laura M., Zaric, Violeta, Gilger, Brian C., Hirsch, Matthew L.

“…AAV gene therapy approaches in the posterior eye resulted in the first FDA-approved gene therapy-based drug. However, application of AAV vectorology to the…”
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RNAi Knockdown of EHMT2 in Maternal Expression of Prader–Willi Syndrome Genes by Zaric, Violeta, Kang, Hye Ri, Rybalchenko, Volodymyr, Zigman, Jeffrey M., Gray, Steven J., Butler, Ryan K.

“…Background/objectives: Euchromatic histone lysine methyltransferase 2 (EHMT2, also known as G9a) is a mammalian histone methyltransferase that catalyzes the…”
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Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe’s Disease after Global Gene Therapy by Marshall, Michael S., Issa, Yazan, Jakubauskas, Benas, Stoskute, Monika, Elackattu, Vince, Marshall, Jeffrey N., Bogue, Wil, Nguyen, Duc, Hauck, Zane, Rue, Emily, Karumuthil-Melethil, Subha, Zaric, Violeta, Bosland, Maarten, van Breemen, Richard B., Givogri, Maria I., Gray, Steven J., Crocker, Stephen J., Bongarzone, Ernesto R.

“…We report a global adeno-associated virus (AAV)9-based gene therapy protocol to deliver therapeutic galactosylceramidase (GALC), a lysosomal enzyme that is…”
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GABAergic somatostatin-immunoreactive neurons in the amygdala project to the entorhinal cortex by McDonald, A.J, Zaric, V

“…Highlights • Most amygdalar neurons labeled by Fluorogold injections into the entorhinal cortex are located in the basolateral amygdala. • About 1–5% of these…”
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Identification of novel AAV capsids for treatment of lysosomal disorders by Chen, Daphne, Padegimas, Linas, Zaric, Violeta, Miller, Timothy J., Gray, Steven

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Localization of the M2 muscarinic cholinergic receptor in dendrites, cholinergic terminals, and noncholinergic terminals in the rat basolateral amygdala: An ultrastructural analysis by Muller, Jay F., Mascagni, Franco, Zaric, Violeta, Mott, David D., McDonald, Alexander J.

“…ABSTRACT Activation of M2 muscarinic receptors (M2Rs) in the rat anterior basolateral nucleus (BLa) is critical for the consolidation of memories of…”
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Effect of genetic deletion or pharmacological antagonism of tumor necrosis factor alpha on colitis-associated carcinogenesis in mice by Craven, Brian, Zaric, Violeta, Martin, Abigail, Mureau, Coralie, Egan, Laurence John

“…Intestinal inflammation in inflammatory bowel diseases is driven by abnormal levels of proinflammatory cytokines, where tumor necrosis factor (TNF)-α seems to…”
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Localization of the M2 Muscarinic Cholinergic Receptor in Dendrites, Cholinergic Terminals and Non-cholinergic Terminals in the Rat Basolateral Amygdala: An Ultrastructural Analysis by Muller, Jay F., Mascagni, Franco, Zaric, Violeta, Mott, David D., McDonald, Alexander J.

“…Activation of M2 muscarinic receptors (M2Rs) in the rat anterior basolateral nucleus (BLa) is critical for the consolidation of memories of emotionally…”
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Extrinsic origins of the somatostatin and neuropeptide Y innervation of the rat basolateral amygdala by McDonald, A.J, Zaric, V

“…Highlights • 2% of cells in the entorhinal cortex that project to the BLC contain somatostatin (SOM). • Some of these nonpyramidal neurons also express NPY and…”
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Potential of cannabinoids to modulate the inflammatory response in colitis (87.1) by Zaric, Violeta, Busbee, Brandon, Nagarkatti, Prakash, Nagarkatti, Mitzi

“…Abstract Recent studies have suggested the role for cannabinoid (CB) type 1 and CB2 receptors in modulating gastrointestinal inflammation in animal models of…”
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53 TNF-α Knockout Mice Are Not Protected Against Colitis-Associated Cancer by Zaric, Violeta, Craven, Brian, Inderhaug, Celine, Egan, Laurence J

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Effective polyethylenimine-mediated gene transfer into human endothelial cells by Zaric, Violeta, Weltin, Denis, Erbacher, Patrick, Remy, Jean-Serge, Behr, Jean-Paul, Stephan, Dominique

“…Background The major advantage in choosing non‐viral vectors such as cationic polymers for in vitro and in vivo transfection is their higher biosafety than…”
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N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF—A significant increase in potency using per-O-acetylated sugar analogues by Rawe, Sarah L., Zaric, Violeta, O’ Boyle, Kathy M., Murphy, Paul V.

“…Per-O-acetylated- N-glucosyl-thiophene-2-carboxamides showed significant inhibition of both serum and bFGF stimulated uptake of [ 3H]thymidine, when compared…”
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