Search Results - "Zaretsky, Mariana"

Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties by Lior, Yotam, Zaretsky, Mariana, Ochayon, David E, Lotysh, Diana, Baranovski, Boris M, Schuster, Ronen, Guttman, Ofer, Aharoni, Amir, Lewis, Eli C

“…Human α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase a sequence-specific molecular…”
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Application of directed evolution and back-to-consensus algorithms to human alpha1-antitrypsin leads to diminished anti-protease activity and augmented anti-inflammatory activities by Lior, Yotam, Jasevitch, Maria, Ochayon, David E., Zaretsky, Mariana, Lewis, Eli C., Aharoni, Amir

“…[Display omitted] •Guided by directed evolution, point mutations were applied to human α1-antitrypsin.•Upon recombinant production (i) anti-protease attributes…”
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