Search Results - "Zaret, Kenneth S"

Pioneer Transcription Factors Initiating Gene Network Changes by Zaret, Kenneth S

“…Pioneer transcription factors have the intrinsic biochemical ability to scan partial DNA sequence motifs that are exposed on the surface of a nucleosome and…”
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Facilitators and Impediments of the Pluripotency Reprogramming Factors' Initial Engagement with the Genome by Soufi, Abdenour, Donahue, Greg, Zaret, Kenneth S.

“…The ectopic expression of transcription factors can reprogram cell fate, yet it is unknown how the initial binding of factors to the genome relates…”
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Pioneer transcription factors in cell reprogramming by Iwafuchi-Doi, Makiko, Zaret, Kenneth S

“…A subset of eukaryotic transcription factors possesses the remarkable ability to reprogram one type of cell into another. The transcription factors that…”
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Role of H3K9me3 heterochromatin in cell identity establishment and maintenance by Nicetto, Dario, Zaret, Kenneth S.

“…Compacted, transcriptionally repressed chromatin, referred to as heterochromatin, represents a major fraction of the higher eukaryotic genome and exerts…”
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Cell fate control by pioneer transcription factors by Iwafuchi-Doi, Makiko, Zaret, Kenneth S

“…Distinct combinations of transcription factors are necessary to elicit cell fate changes in embryonic development. Yet within each group of fate-changing…”
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Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming by Soufi, Abdenour, Garcia, Meilin Fernandez, Jaroszewicz, Artur, Osman, Nebiyu, Pellegrini, Matteo, Zaret, Kenneth S

“…Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes, using diverse types of DNA binding domains (DBDs). FoxA, the…”
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Pioneer transcription factors, chromatin dynamics, and cell fate control by Zaret, Kenneth S, Mango, Susan E

“…Among the diverse transcription factors that are necessary to elicit changes in cell fate, both in embryonic development and in cellular reprogramming, a…”
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Pioneer transcription factors: establishing competence for gene expression by Zaret, Kenneth S, Carroll, Jason S

“…Transcription factors are adaptor molecules that detect regulatory sequences in the DNA and target the assembly of protein complexes that control gene…”
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G&D vignettes by Zaret, Kenneth S

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Generation and Regeneration of Cells of the Liver and Pancreas by Zaret, Kenneth S, Grompe, Markus

“…Liver and pancreas progenitors develop from endoderm cells in the embryonic foregut. Shortly after their specification, liver and pancreas progenitors rapidly…”
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Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation by Zaret, Kenneth S

“…Key Points The liver and pancreas both arise from a multipotent population of endoderm cells and share many characteristics of their early development,…”
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The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation by Iwafuchi-Doi, Makiko, Donahue, Greg, Kakumanu, Akshay, Watts, Jason A., Mahony, Shaun, Pugh, B. Franklin, Lee, Dolim, Kaestner, Klaus H., Zaret, Kenneth S.

“…Nuclear DNA wraps around core histones to form nucleosomes, which restricts the binding of transcription factors to gene regulatory sequences. Pioneer…”
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Dynamic Signaling Network for the Specification of Embryonic Pancreas and Liver Progenitors by Wandzioch, Ewa, Zaret, Kenneth S

“…Studies of the formation of pancreas and liver progenitors have focused on individual inductive signals and cellular responses. Here, we investigated how bone…”
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Cell and tissue engineering for liver disease by Bhatia, Sangeeta N, Underhill, Gregory H, Zaret, Kenneth S, Fox, Ira J

“…Despite the tremendous hurdles presented by the complexity of the liver's structure and function, advances in liver physiology, stem cell biology and…”
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Mitotic transcription and waves of gene reactivation during mitotic exit by Palozola, Katherine C., Donahue, Greg, Liu, Hong, Grant, Gregory R., Becker, Justin S., Cote, Allison, Yu, Hongtao, Raj, Arjun, Zaret, Kenneth S.

“…Although the genome is generally thought to be transcriptionally silent during mitosis, technical limitations have prevented sensitive mapping of transcription…”
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Chromatin Scanning by Dynamic Binding of Pioneer Factors by Zaret, Kenneth S., Lerner, Jonathan, Iwafuchi-Doi, Makiko

“…Pioneer factors such as FoxA target nucleosomal DNA and initiate cooperative interactions at silent genes during development, cellular reprogramming, and…”
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Genomic and Proteomic Resolution of Heterochromatin and Its Restriction of Alternate Fate Genes by Becker, Justin S., McCarthy, Ryan L., Sidoli, Simone, Donahue, Greg, Kaeding, Kelsey E., He, Zhiying, Lin, Shu, Garcia, Benjamin A., Zaret, Kenneth S.

“…Heterochromatin is integral to cell identity maintenance by impeding the activation of genes for alternate cell fates. Heterochromatic regions are associated…”
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Genome Reactivation after the Silence in Mitosis: Recapitulating Mechanisms of Development? by Zaret, Kenneth S.

“…Transcription is silenced during mitosis and reactivated at mitotic exit. The dynamics and identities of “bookmarking” transcription factors and chromatin…”
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Two-Parameter Mobility Assessments Discriminate Diverse Regulatory Factor Behaviors in Chromatin by Lerner, Jonathan, Gomez-Garcia, Pablo Aurelio, McCarthy, Ryan L., Liu, Zhe, Lakadamyali, Melike, Zaret, Kenneth S.

“…Enzymatic probes of chromatin structure reveal accessible versus inaccessible chromatin states, while super-resolution microscopy reveals a continuum of…”
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Reprogramming of human cancer cells to pluripotency for models of cancer progression by Kim, Jungsun, Zaret, Kenneth S

“…The ability to study live cells as they progress through the stages of cancer provides the opportunity to discover dynamic networks underlying pathology,…”
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