Search Results - "Zarella, Mark"

A Practical Guide to Whole Slide Imaging: A White Paper From the Digital Pathology Association by Zarella, Mark D, Bowman, Douglas, Aeffner, Famke, Farahani, Navid, Xthona, Albert, Absar, Syeda Fatima, Parwani, Anil, Bui, Marilyn, Hartman, Douglas J

“…Whole slide imaging (WSI) represents a paradigm shift in pathology, serving as a necessary first step for a wide array of digital tools to enter the field. Its…”
Get full text

Introduction to Digital Image Analysis in Whole-slide Imaging: A White Paper from the Digital Pathology Association by Aeffner, Famke, Zarella, Mark D., Buchbinder, Nathan, Bui, Marilyn M., Goodman, Matthew R., Hartman, Douglas J., Lujan, Giovanni M., Molani, Mariam A., Parwani, Anil V., Lillard, Kate, Turner, Oliver C., Vemuri, Venkata N.P., Yuil-Valdes, Ana G., Bowman, Douglas

“…The advent of whole-slide imaging in digital pathology has brought about the advancement of computer-aided examination of tissue via digital image analysis…”
Get full text

Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association by Abels, Esther, Pantanowitz, Liron, Aeffner, Famke, Zarella, Mark D, Laak, Jeroen, Bui, Marilyn M, Vemuri, Venkata NP, Parwani, Anil V, Gibbs, Jeff, Agosto‐Arroyo, Emmanuel, Beck, Andrew H, Kozlowski, Cleopatra

“…In this white paper, experts from the Digital Pathology Association (DPA) define terminology and concepts in the emerging field of computational pathology,…”
Get full text

High‐throughput whole‐slide scanning to enable large‐scale data repository building by Zarella, Mark D, Rivera Alvarez, Keysabelis

“…Digital pathology and artificial intelligence (AI) rely on digitization of patient material as a necessary first step. AI development benefits from large…”
Get full text

An alternative reference space for H&E color normalization by Zarella, Mark D, Yeoh, Chan, Breen, David E, Garcia, Fernando U

“…Digital imaging of H&E stained slides has enabled the application of image processing to support pathology workflows. Potential applications include…”
Get full text

Video compression to support the expansion of whole-slide imaging into cytology by Zarella, Mark D, Jakubowski, Jennifer

“…Digital screening and diagnosis from cytology slides can be aided by capturing multiple focal planes. However, using conventional methods, the large file sizes…”
Get full text

Quantitative Image Analysis for Tissue Biomarker Use: A White Paper From the Digital Pathology Association by Lara, Haydee, Li, Zaibo, Abels, Esther, Aeffner, Famke, Bui, Marilyn M., ElGabry, Ehab A., Kozlowski, Cleopatra, Montalto, Michael C., Parwani, Anil V., Zarella, Mark D., Bowman, Douglas, Rimm, David, Pantanowitz, Liron

“…Tissue biomarkers have been of increasing utility for scientific research, diagnosing disease, and treatment response prediction. There has been a steady shift…”
Get full text

Continuing Undergraduate Pathology Medical Education in the Coronavirus Disease 2019 (COVID-19) Global Pandemic by White, Marissa J, Birkness, Jacqueline E, Salimian, Kevan J, Meiss, Alice E, Butcher, Monica, Davis, Katelynn, Ware, Alisha D, Zarella, Mark D, Lecksell, Kristen, Rooper, Lisa M, Cimino-Mathews, Ashley, VandenBussche, Christopher J, Halushka, Marc K, Thompson, Elizabeth D

“…[...]in the earliest weeks of the global COVID-19 pandemic, undergraduate medical education pivoted from close and intense in-person education and interactions…”
Get full text

Continuing Undergraduate Pathology Medical Education in the Coronavirus Disease 2019 (COVID-19) Global Pandemic: The Johns Hopkins Virtual Surgical Pathology Clinical Elective by White, Marissa J, Birkness, Jacqueline E, Salimian, Kevan J, Meiss, Alice E, Butcher, Monica, Davis, Katelynn, Ware, Alisha D, Zarella, Mark D, Lecksell, Kristen, Rooper, Lisa M, Cimino-Mathews, Ashley, VandenBussche, Christopher J, Halushka, Marc K, Thompson, Elizabeth D

“…In the early months of the response to the coronavirus disease 2019 (COVID-19) pandemic, the Johns Hopkins University School of Medicine (JHUSOM) (Baltimore,…”
Get full text

Laboratory Computer Performance in a Digital Pathology Environment: Outcomes from a Single Institution by Zarella, Mark D., Feldscher, Adam

“…Background: In an effort to provide improved user experience and system reliability at a moderate cost, our department embarked on targeted upgrades of a total…”
Get full text

Dissecting the Business Case for Adoption and Implementation of Digital Pathology: A White Paper from the Digital Pathology Association by Lujan, Giovanni, Quigley, Jennifer C., Hartman, Douglas, Parwani, Anil, Roehmholdt, Brian, Van Meter, Bryan, Ardon, Orly, Hanna, Matthew G., Kelly, Dan, Sowards, Chelsea, Montalto, Michael, Bui, Marilyn, Zarella, Mark D., LaRosa, Victoria, Slootweg, Gerard, Retamero, Juan Antonio, Lloyd, Mark C., Madory, James, Bowman, Doug

“…We believe the switch to a digital pathology (DP) workflow is imminent and it is essential to understand the economic implications of conversion. Many aspects…”
Get full text

Estimation of Fine-Scale Histologic Features at Low Magnification by Zarella, Mark D, Quaschnick, Matthew R, Breen, David E, Garcia, Fernando U

“…Whole-slide imaging has ushered in a new era of technology that has fostered the use of computational image analysis for diagnostic support and has begun to…”
Get full text

Artificial intelligence and digital pathology: clinical promise and deployment considerations by Zarella, Mark D., McClintock, David S., Batra, Harsh, Gullapalli, Rama R., Valante, Michael, Tan, Vivian O., Dayal, Shubham, Oh, Kei Shing, Lara, Haydee, Garcia, Chris A., Abels, Esther

“…Artificial intelligence (AI) presents an opportunity in anatomic pathology to provide quantitative objective support to a traditionally subjective discipline,…”
Get full text

Whither the hypercolumn? by Ts'o, Daniel Y., Zarella, Mark, Burkitt, Guy

“…Among the crowning achievements of Hubel and Wiesel's highly influential studies on primary visual cortex is the description of the cortical hypercolumn, a set…”
Get full text

BCL-2 expression aids in the immunohistochemical prediction of the Oncotype DX breast cancer recurrence score by Zarella, Mark D, Heintzelman, Rebecca C, Popnikolov, Nikolay K, Garcia, Fernando U

“…The development of molecular techniques to estimate the risk of breast cancer recurrence has been a significant addition to the suite of tools available to…”
Get full text

Lymph Node Metastasis Status in Breast Carcinoma Can Be Predicted via Image Analysis of Tumor Histology by Zarella, Mark D, Breen, David E, Reza, Alimoor, Milutinovic, Aladin, Garcia, Fernando U

“…To develop a method whereby axillary lymph node (ALN) metastasis can be predicted without ALN dissection, via computational image analysis of routinely…”
Get more information

The Future of Pathology: What can we Learn from the COVID-19 Pandemic? by Williams, Bethany J, Fraggetta, Filippo, Hanna, Matthew G., Huang, Richard, Lennerz, Jochen, Salgado, Roberto, Sirintrapun, S. Joseph, Pantanowitz, Liron, Parwani, Anil, Zarella, Mark, Treanor, Darren E

Get full text

Contextual modulation revealed by optical imaging exhibits figural asymmetry in macaque V1 and V2 by Zarella, Mark D, Ts'o, Daniel Y

“…Neurons in early visual cortical areas are influenced by stimuli presented well beyond the confines of their classical receptive fields, endowing them with the…”
Get full text

An optimized color transformation for the analysis of digital images of hematoxylin & eosin stained slides by Zarella, Mark D., Breen, David E., Plagov, Andrei, Garcia, Fernando U.

“…Hematoxylin and eosin (H&E) staining is ubiquitous in pathology practice and research. As digital pathology has evolved, the reliance of quantitative methods…”
Get full text

Cue combination encoding via contextual modulation of V1 and V2 neurons by Zarella, Mark D, Ts'o, Daniel Y

“…Neurons in early visual cortical areas encode the local properties of a stimulus in a number of different feature dimensions such as color, orientation, and…”
Get full text