The association between circulating 25-hydroxyvitamin D and cardiovascular diseases: a meta-analysis of prospective cohort studies

There is a controversy about the association between vitamin D and cardiovascular diseases (CVDs). The effect of serum 25-OH-vitD on the risk of CVDs was evaluated. Major electronic databases including Scopus, Science Direct, and PubMed were searched. All prospective cohort studies on the relationsh...

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Bibliographic Details
Published in:	BMC cardiovascular disorders Vol. 19; no. 1; p. 248
Main Authors:	Gholami, Fatemeh, Moradi, Ghobad, Zareei, Bushra, Rasouli, Mohammad Aziz, Nikkhoo, Bahram, Roshani, Daem, Ghaderi, Ebrahim
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 07-11-2019 BioMed Central BMC
Subjects:	Analysis Cardiovascular disease Cardiovascular diseases Medical research Meta-analysis Mortality Prospective cohort study Vitamin D Vitamin D deficiency Vitamins Cardiovascular disease Vitamin D Prospective cohort study Meta-analysis
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Summary:	There is a controversy about the association between vitamin D and cardiovascular diseases (CVDs). The effect of serum 25-OH-vitD on the risk of CVDs was evaluated. Major electronic databases including Scopus, Science Direct, and PubMed were searched. All prospective cohort studies on the relationship between vitamin D status and CVDs conducted between April 2000 and September 2017 were included, regardless language. The study participants were evaluated regardless of their age, sex, and ethnicity. The Newcastle-Ottawa Scale was used to assess the quality of the studies. Two investigators independently selected the studies and extracted the data. The designated effects were risk ratio (RR) and hazard ratio (HR). The random effects model was used to combine the results. A meta-analysis of 25 studies with 10,099 cases of CVDs was performed. In general, a decrease in the level of vitamin D was associated with a higher relative risk of CVDs (incidence-mortality combined) (RR = 1.44, 95% CI: 1.24-1.69). This accounts for 54% of CVDs mortality rate (RR = 1.54, 95% CI: 1.29-1.84(. However, no significant relationship was observed between the vitamin D status and incidence of CVDs (RR = 1.18, 95% CI: 1-1.39). In general, low serum vitamin D level increased the risk of CVD by 44% (RR = 1.44, 95% CI: 1.24-1.69). It also increased the risk of CVD mortality (RR = 1.54, 95% CI: 1.29-1.84) and incidence rates (RR = 1.18, 95% CI: 1-1.39). The findings showed that vitamin D deficiency increases the CVDs mortality rate. Due to the limited number of studies on patients of the both genders, further research is suggested to separately evaluate the effect of vitamin D status on CVD in men and women.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	1471-2261 1471-2261
DOI:	10.1186/s12872-019-1236-7