Antiphospholipid antibodies proposed in the diagnosis of infective endocarditis

Antiphospholipid antibodies proposed in the diagnosis of infective endocarditis

Antiphospholipid antibodies (aPL) may occur alone or associated with other diseases. To evaluate aPL, tested as anticardiolipin antibodies (IgG aCL) in infective endocarditis (IE) diagnosis, we investigated their prevalence in a cohort of 651 patients with IE suspicion. aPL was significantly associa...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases Vol. 36; no. 7; pp. 1159 - 1162
Main Authors: Zaratzian, C., Gouriet, F., Tissot-Dupont, H., Casalta, J.-P., Million, M., Bardin, N., Grisoli, D., Habib, G., Raoult, D.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2017
Springer Nature B.V
Springer Verlag
Subjects:
Aged
Aged, 80 and over
Antibodies
Antibodies, Antiphospholipid - blood
Antiphospholipid antibodies
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Cardiolipin
Diagnosis
Endocarditis
Endocarditis - diagnosis
Female
Human health and pathology
Humans
Immunoglobulin G
Immunoglobulins
Infectious diseases
Internal Medicine
Life Sciences
Male
Medical Microbiology
Middle Aged
Original Article
Patients
Systemic Lupus Erythematosus
Heart Valve Disease
Coxiella Burnetii
Endocarditis
Infective Endocarditis
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Description
Summary:Antiphospholipid antibodies (aPL) may occur alone or associated with other diseases. To evaluate aPL, tested as anticardiolipin antibodies (IgG aCL) in infective endocarditis (IE) diagnosis, we investigated their prevalence in a cohort of 651 patients with IE suspicion. aPL was significantly associated with definite IE versus IE-rejected patients. Their mean levels were significantly higher in patients with definite IE versus possible IE. When applied as Duke minor criterion, they were significantly more often positive, and at higher levels, in patients with definite IE than in patients with possible or rejected IE. aPL could be helpful in difficult cases of IE diagnosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-017-2903-1