Search Results - "Zar, Heather J."

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants by Hammitt, Laura L, Dagan, Ron, Yuan, Yuan, Baca Cots, Manuel, Bosheva, Miroslava, Madhi, Shabir A, Muller, William J, Zar, Heather J, Brooks, Dennis, Grenham, Amy, Wählby Hamrén, Ulrika, Mankad, Vaishali S, Ren, Pin, Takas, Therese, Abram, Michael E, Leach, Amanda, Griffin, M. Pamela, Villafana, Tonya

“…Nirsevimab is a monoclonal antibody to the RSV fusion protein that has an extended half-life. In this clinical trial, a single dose of nirsevimab resulted in a…”
Get full text

Towards a population-based threshold of protection for COVID-19 vaccines by Goldblatt, David, Fiore-Gartland, Andrew, Johnson, Marina, Hunt, Adam, Bengt, Christopher, Zavadska, Dace, Snipe, Hilda Darta, Brown, Jeremy S., Workman, Lesley, Zar, Heather J., Montefiori, David, Shen, Xiaoying, Dull, Peter, Plotkin, Stanley, Siber, George, Ambrosino, Donna

“…Correlates of protection for COVID-19 vaccines are urgently needed to license additional vaccines. We measured immune responses to four COVID-19 vaccines of…”
Get full text

Risk and protective factors for child development: An observational South African birth cohort by Donald, Kirsten Ann, Wedderburn, Catherine J, Barnett, Whitney, Nhapi, Raymond T, Rehman, Andrea M, Stadler, Jacob A M, Hoffman, Nadia, Koen, Nastassja, Zar, Heather J, Stein, Dan J

“…Approximately 250 million (43%) children under the age of 5 years in low- and middle-income countries (LMICs) are failing to meet their developmental…”
Get full text

Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study by Nicol, Mark P, Prof, Workman, Lesley, MSc, Isaacs, Washiefa, BSc, Munro, Jacinta, Black, Faye, MBBCh, Eley, Brian, FCPaed, Boehme, Catharina C, MD, Zemanay, Widaad, PhD, Zar, Heather J, Prof

“…Summary Background WHO recommends that Xpert MTB/RIF replaces smear microscopy for initial diagnosis of suspected HIV-associated tuberculosis or…”
Get full text

Maternal health and birth outcomes in a South African birth cohort study by Zar, Heather J, Pellowski, Jennifer A, Cohen, Sophie, Barnett, Whitney, Vanker, Aneesa, Koen, Nastassja, Stein, Dan J

“…Maternal physical and mental health during pregnancy are key determinants of birth outcomes. There are relatively few prospective data that integrate physical…”
Get full text

Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested case-control study of the Drakenstein Child Health Study by Zar, Heather J, Prof, Barnett, Whitney, MPH, Stadler, Attie, MBChB, Gardner-Lubbe, Sugnet, PhD, Myer, Landon, Prof, Nicol, Mark P, Prof

“…Summary Background Pneumonia is a leading cause of mortality and morbidity in children globally. The cause of pneumonia after introduction of the 13-valent…”
Get full text

Burden of asthma and chronic obstructive pulmonary disease and access to essential medicines in low-income and middle-income countries by Beran, David, PhD, Zar, Heather J, Prof, Perrin, Christophe, MSc, Menezes, Ana M, PhD, Burney, Peter, Prof

“…Summary Demographic and epidemiological transitions are changing the age structure of the population and the most common diseases. Non-communicable respiratory…”
Get full text

The association between bacteria colonizing the upper respiratory tract and lower respiratory tract infection in young children: a systematic review and meta-analysis by Claassen-Weitz, Shantelle, Lim, Katherine Y.L., Mullally, Christopher, Zar, Heather J., Nicol, Mark P.

“…Bacteria colonizing the upper respiratory tract (URT) of young children play a key role in the pathogenesis of lower respiratory tract infection (LRTI). To…”
Get full text

Age-related waning of immune responses to BCG in healthy children supports the need for a booster dose of BCG in TB endemic countries by Whittaker, Elizabeth, Nicol, Mark P., Zar, Heather J., Tena-Coki, Nontobeko G., Kampmann, Beate

“…In the absence of a more effective vaccine against TB and in the interest of developing one, it is essential to understand immune responses associated with BCG…”
Get full text

Lower Respiratory Tract Infections in Children in a Well-vaccinated South African Birth Cohort: Spectrum of Disease and Risk Factors by le Roux, David M, Nicol, Mark P, Myer, Landon, Vanker, Aneesa, Stadler, Jacob A M, von Delft, Eckart, Zar, Heather J

“…Abstract Background Childhood lower respiratory tract infections (LRTIs) cause substantial morbidity and under-5 child mortality. The epidemiology of LRTI is…”
Get full text

Determinants of early-life lung function in African infants by Gray, Diane, Willemse, Lauren, Visagie, Ane, Czövek, Dorottya, Nduru, Polite, Vanker, Aneesa, Stein, Dan J, Koen, Nastassja, Sly, Peter D, Hantos, Zoltán, Hall, Graham L, Zar, Heather J

“…Low lung function in early life is associated with later respiratory illness. There is limited data on lung function in African infants despite a high…”
Get more information

Incidence and severity of childhood pneumonia in the first year of life in a South African birth cohort: the Drakenstein Child Health Study by le Roux, David M, Dr, Myer, Landon, PhD, Nicol, Mark P, PhD, Zar, Heather J, PhD

“…Summary Background Childhood pneumonia causes substantial mortality and morbidity. Accurate measurements of pneumonia incidence are scarce in low-income and…”
Get full text

Neuroimaging young children and associations with neurocognitive development in a South African birth cohort study by Wedderburn, Catherine J., Subramoney, Sivenesi, Yeung, Shunmay, Fouche, Jean-Paul, Joshi, Shantanu H., Narr, Katherine L., Rehman, Andrea M., Roos, Annerine, Ipser, Jonathan, Robertson, Frances C., Groenewold, Nynke A., Gibb, Diana M., Zar, Heather J., Stein, Dan J., Donald, Kirsten A.

“…Magnetic resonance imaging (MRI) is an indispensable tool for investigating brain development in young children and the neurobiological mechanisms underlying…”
Get full text

Language outcomes of preschool children who are HIV-exposed uninfected: An analysis of a South African cohort by Green, Freddy, du Plooy, Christopher, Rehman, Andrea M, Nhapi, Raymond T, Lake, Marilyn T, Barnett, Whitney, Hoffman, Nadia, Zar, Heather J, Donald, Kirsten A, Stein, Dan J, Wedderburn, Catherine J

“…There are approximately 16 million children who are HIV-exposed and uninfected (CHEU) worldwide. Studies suggest that CHEU are at risk for developmental…”
Get full text

Risk Factors for Severe COVID‐19 Among Children and Adolescents Enrolled in Acute Respiratory Infection Sentinel Surveillance in South Africa, 2020–2022 by Bishop, Kate, Meiring, Susan, Tempia, Stefano, Gottberg, Anne, Wolter, Nicole, Kleynhans, Jackie, Moosa, Fahima, Plessis, Mignon, Moyes, Jocelyn, Makhasi, Mvuyo, Chuene, Boitumelo, Samuels, Aaron M., Dawood, Halima, Reubenson, Gary, Zar, Heather J., Quan, Vanessa, Cohen, Cheryl, Walaza, Sibongile

“…ABSTRACT Background Identifying children at risk for severe COVID‐19 disease from severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) may guide future…”
Get full text

Genetic susceptibility to asthma increases the vulnerability to indoor air pollution by Hüls, Anke, Vanker, Aneesa, Gray, Diane, Koen, Nastassja, MacIsaac, Julia L, Lin, David T S, Ramadori, Katia E, Sly, Peter D, Stein, Dan J, Kobor, Michael S, Zar, Heather J

“…Indoor air pollution and maternal smoking during pregnancy are associated with respiratory symptoms in infants, but little is known about the direct…”
Get full text

Effectiveness of monovalent human rotavirus vaccine against admission to hospital for acute rotavirus diarrhoea in South African children: a case-control study by Groome, Michelle J, Dr, Page, Nicola, PhD, Cortese, Margaret M, MD, Moyes, Jocelyn, MBBCh, Zar, Heather J, Prof, Kapongo, Constant N, FCPaeds[SA], Mulligan, Christine, MBChB, Diedericks, Ralph, FCP[Paed], Cohen, Cheryl, MBBCh, Fleming, Jessica A, PhD, Seheri, Mapaseka, PhD, Mphahlele, Jeffrey, Prof, Walaza, Sibongile, MBBCh, Kahn, Kathleen, PhD, Chhagan, Meera, Dr, Steele, A Duncan, PhD, Parashar, Umesh D, MBBS, Zell, Elizabeth R, MStat, Madhi, Shabir A, Prof

“…Summary Background The effectiveness of the rotavirus vaccine under conditions of routine use in an African setting with a high prevalence of HIV infection…”
Get full text

Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection by Magodoro, Itai M., Guerrero-Chalela, Carlos E., Claggett, Brian, Jermy, Stephen, Samuels, Petronella, Myer, Landon, Zar, Heather J, Jao, Jennifer, Ntsekhe, Mpiko, Siedner, Mark J., Ntusi, Ntobeko A. B.

“…Whether, and how, cardioprotective effects of antiretroviral treatment (ART) in adolescents with perinatal HIV infection (APHIV) vary with age at treatment…”
Get full text

Diagnostic limitations of clinical case definitions of pertussis in infants and children with severe lower respiratory tract infection by Muloiwa, Rudzani, Nicol, Mark P, Hussey, Gregory D, Zar, Heather J

“…Diagnosis of pertussis is challenging especially in infants. Most low and middle-income countries (LMIC) lack resources for laboratory confirmation, relying…”
Get full text

Cognition, Structural Brain Changes, and Systemic Inflammation in Adolescents Living With HIV on Antiretroviral Therapy by Hoare, Jacqueline, Myer, Landon, Heany, Sarah, Fouche, Jean-Paul, Phillips, Nicole, Zar, Heather J., Stein, Dan J.

“…OBJECTIVE:To investigate the association between neurocognitive impairment, neuroimaging, and systemic inflammation in perinatally infected adolescents living…”
Get full text