Lectin binding in the human foetal testis

In the present study we have investigated the oligosaccharidic content of the glycoconjugates within the human foetal testis starting from its earliest differentiation phase (8, 10 and 12 weeks of gestation). To this purpose we have used a battery of six horseradish peroxidase-labelled lectins (SBA,...

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Bibliographic Details
Published in:	Histology and histopathology Vol. 18; no. 3; pp. 735 - 740
Main Authors:	Gheri, G, Vannelli, G B, Marini, M, Zappoli Thyrion, G P, Sgambati, E
Format:	Journal Article
Language:	English
Published:	Spain 01-07-2003
Subjects:	Cell Differentiation Endothelial Cells - metabolism Epithelium - metabolism Glucose Oxidase - metabolism Humans Lectins - metabolism Leydig Cells - metabolism Male N-Acetylneuraminic Acid - metabolism Neuraminidase - metabolism Oligosaccharides - chemistry Oligosaccharides - metabolism Sertoli Cells - metabolism Testis - embryology Time Factors
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Summary:	In the present study we have investigated the oligosaccharidic content of the glycoconjugates within the human foetal testis starting from its earliest differentiation phase (8, 10 and 12 weeks of gestation). To this purpose we have used a battery of six horseradish peroxidase-labelled lectins (SBA, PNA, WGA, UEAI, LTA and ConA). We have obtained a complete distributional map of the sugar residues of the glycoconjugates in the coelomic mesothelium, tunica albuginea, pre-Sertoli cells, pre-gonocytes, Leydig cells, basement membrane of the sex cords, interstitial tissue, mastocytes and endothelial cells of the capillary vessels. Since the beginning of the testis differentiation phase the cells of the coelomic mesothelium showed a large amount of sugar residues. In the pre-Sertoli cells and in the pre-gonocytes a role played as structural molecules by some oligosaccharides could be hypothesized. D-galactose-(beta1-->3)-N-acetyl-D-galactosamine, sialic acid, N-acetyl-D-glucosamine and alpha-D-mannose could be involved in inducing and maintaining the cellular activity of the Leydig cells.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0213-3911
DOI:	10.14670/HH-18.735