Search Results - "Zapf, Jim"

ViruClear: Molecularly designed biomimetic nanosponges for prevention and treatment of SARS‐CoV‐2 infections in COVID‐19 patients by Esmaeli‐Azad, Babak, Federico, Isabella, Rojas, Fernando, Zapf, Jim

“…The current COVID‐19 pandemic infectious disease agent SARS‐CoV‐2, like its’ cousin SARS‐CoV, uses a variety of entry receptors including angiotensin…”
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A human stem cell phenotypic drug screening assay for identification of opioid and non‐opioid analgesics with lowered risk of addiction by Esmaeli‐Azad, Babak, Federico, Niksha, Rojas, Fernando, Zapf, Jim

“…Mu opioid receptors, a subclass of G protein‐coupled receptors (GPCRs), are involved in the control of pain perception and reward properties. They are also the…”
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Countermeasures for Preventing and Treating Opioid Overdose by France, Charles P., Ahern, Gerard P., Averick, Saadyah, Disney, Alex, Enright, Heather A., Esmaeli‐Azad, Babak, Federico, Arianna, Gerak, Lisa R., Husbands, Stephen M., Kolber, Benedict, Lau, Edmond Y., Lao, Victoria, Maguire, David R., Malfatti, Michael A., Martinez, Girardo, Mayer, Brian P., Pravetoni, Marco, Sahibzada, Niaz, Skolnick, Phil, Snyder, Evan Y., Tomycz, Nestor, Valdez, Carlos A., Zapf, Jim

“…The only medication available currently to prevent and treat opioid overdose (naloxone) was approved by the US Food and Drug Administration (FDA) nearly…”
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Tu1744 - Ex Vivo Effects of Ror-Gamma T Inhibitors on Proinflammatory Cytokine Secretion from Colonic Strips of Mice with DSS-Induced Colitis by Fitzpatrick, Leo R., Talbott, George, Buhr, Chris A., Alton, Gordon, Zapf, Jim

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VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease by Fitzpatrick, Leo R., Small, Jeff, O’Connell, Robert, Talbott, George, Alton, Gordon, Zapf, Jim

“…Introduction Retinoic Acid Related Orphan Nuclear Receptor gamma T (RORγT) is a lineage specifying transcription factor for IL-17 expressing cells, which may…”
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107 - A Novel ROR-Gamma T Inhibitor (VPR-254) Attenuates Key Parameters of Innate Immune Colitis in Mice by Fitzpatrick, Leo R., O'Connell, Robert, Talbott, George, Bendele, Phillip, Alton, Gordon, Zapf, Jim

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A Novel ROR-Gamma T Inhibitor (VPR-254) Attenuates Key Parameters of Innate Immune Colitis in Mice by Fitzpatrick, Leo R, O'Connell, Robert, Talbott, George, Bendele, Phillip, Alton, Gordon, Zapf, Jim

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90 Efficacy of a Novel Small Molecule RORgt Inverse Agonist in Mouse DSS and TNBS Models of Inflammatory Bowel Disease by Fitzpatrick, Leo R, Zapf, Jim, Flood, Elizabeth M, Ravula, Satheesh B, Lingardo, Laura K, Small, Jeff, Tucci, Fabio, Buhr, Chris A, Alton, Gordon

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