Search Results - "Zapatero, J"

Study of crack orientation and fatigue life prediction in biaxial fatigue with critical plane models by Lopez-Crespo, P., Moreno, B., Lopez-Moreno, A., Zapatero, J.

“…•Biaxial fatigue behaviour was characterised in initiation and propagation stages.•Crack growth rate at initiation showed oscillations due to…”
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Innate immune response to SARS‐CoV‐2 infection contributes to neuronal damage in human iPSC‐derived peripheral neurons by Passos, Vania, Henkel, Lisa M., Wang, Jiayi, Zapatero‐Belinchón, Francisco J., Möller, Rebecca, Sun, Guorong, Waltl, Inken, Schneider, Talia, Wachs, Amelie, Ritter, Birgit, Kropp, Kai A., Zhu, Shuyong, Deleidi, Michela, Kalinke, Ulrich, Schulz, Thomas F., Höglinger, Günter, Gerold, Gisa, Wegner, Florian, Viejo‐Borbolla, Abel

“…Severe acute respiratory coronavirus 2 (SARS‐CoV‐2) causes neurological disease in the peripheral and central nervous system (PNS and CNS, respectively) of…”
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Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease by Ricke-Hoch, Melanie, Stelling, Elisabeth, Lasswitz, Lisa, Gunesch, Antonia P, Kasten, Martina, Zapatero-Belinchón, Francisco J, Brogden, Graham, Gerold, Gisa, Pietschmann, Thomas, Montiel, Virginie, Balligand, Jean-Luc, Facciotti, Federica, Hirsch, Emilio, Gausepohl, Thomas, Elbahesh, Husni, Rimmelzwaan, Guus F, Höfer, Anne, Kühnel, Mark P, Jonigk, Danny, Eigendorf, Julian, Tegtbur, Uwe, Mink, Lena, Scherr, Michaela, Illig, Thomas, Schambach, Axel, Pfeffer, Tobias J, Hilfiker, Andres, Haverich, Axel, Hilfiker-Kleiner, Denise

“…The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease…”
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The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity by Carriquí-Madroñal, Belén, Sheldon, Julie, Duven, Mara, Stegmann, Cora, Cirksena, Karsten, Wyler, Emanuel, Zapatero-Belinchón, Francisco J, Vondran, Florian W. R, Gerold, Gisa

“…Hepatitis C virus (HCV) exploits the four entry factors CD81, scavenger receptor class B type I (SR-BI, also known as SCARB1), occludin, and claudin-1 as well…”
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Structure-Based Discovery of Inhibitors of the SARS-CoV‑2 Nsp14 N7-Methyltransferase by Singh, Isha, Li, Fengling, Fink, Elissa A., Chau, Irene, Li, Alice, Rodriguez-Hernández, Annía, Glenn, Isabella, Zapatero-Belinchón, Francisco J., Rodriguez, M. Luis, Devkota, Kanchan, Deng, Zhijie, White, Kris, Wan, Xiaobo, Tolmachova, Nataliya A., Moroz, Yurii S., Kaniskan, H. Ümit, Ott, Melanie, García-Sastre, Adolfo, Jin, Jian, Fujimori, Danica Galonić, Irwin, John J., Vedadi, Masoud, Shoichet, Brian K.

“…An under-explored target for SARS-CoV-2 is the S-adenosyl methionine (SAM)-dependent methyltransferase Nsp14, which methylates the N7-guanosine of viral RNA at…”
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The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication by Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Moeller, Rebecca, Hülskötter, Kirsten, Laurent, Timothée, Carlson, Lars-Anders, Goffinet, Christine, Simmons, Graham, Baumgärtner, Wolfgang, Gerold, Gisa

“…Chikungunya virus (CHIKV) is an arthritogenic reemerging virus replicating in plasma membrane-derived compartments termed "spherules." Here, we identify the…”
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Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection by Mhlekude, Baxolele, Postmus, Dylan, Stenzel, Saskia, Weiner, 3rd, January, Jansen, Jenny, Zapatero-Belinchón, Francisco J, Olmer, Ruth, Richter, Anja, Heinze, Julian, Heinemann, Nicolas, Mühlemann, Barbara, Schroeder, Simon, Jones, Terry C, Müller, Marcel A, Drosten, Christian, Pich, Andreas, Thiel, Volker, Martin, Ulrich, Niemeyer, Daniela, Gerold, Gisa, Beule, Dieter, Goffinet, Christine

“…Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection…”
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Human tetraspanin CD81 facilitates invasion of Salmonella enterica into human epithelial cells by Alvarez, Kris Gerard, Goral, Lisa, Suwandi, Abdulhadi, Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Ehrhardt, Katrin, Nagarathinam, Kumar, Künnemann, Katrin, Krey, Thomas, Wiedemann, Agnes, Gerold, Gisa, Grassl, Guntram A

“…Human CD81 and CD9 are members of the tetraspanin family of proteins characterized by a canonical structure of four transmembrane domains and two extracellular…”
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Characterisation of crack-tip fields in biaxial fatigue based on high-magnification image correlation and electro-spray technique by Lopez-Crespo, P., Moreno, B., Lopez-Moreno, A., Zapatero, J.

“…This work presents a novel methodology for characterising fatigue cracks under biaxial conditions on a low carbon steel. It allows both short crack and early…”
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Estimations of fatigue life and variability under random loading in aluminum Al-2024T351 using strip yield models from NASGRO by Moreno, B., Martin, A., Lopez-Crespo, P., Zapatero, J., Dominguez, J.

“…•The strip yield models implemented in NASGRO software are used.•Constant constraint-loss model and variable constraint-loss model are compared.•A new crack…”
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Influence of minimum element size to determine crack closure stress by the finite element method by González-Herrera, A., Zapatero, J.

“…Measuring opening or closure stress is a complex process that influences the low accuracy of obtained data. Finite element models have been one of the…”
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Tri-dimensional numerical modelling of plasticity induced fatigue crack closure by Gonzalez-Herrera, A., Zapatero, J.

“…Fatigue crack closure has been studied numerically with 2D finite element models as alternative to experimental methods. In a few cases fatigue crack closure…”
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Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors by Zapatero-Belinchón, Francisco J, Dietzel, Erik, Dolnik, Olga, Döhner, Katinka, Costa, Rui, Hertel, Barbara, Veselkova, Barbora, Kirui, Jared, Klintworth, Anneke, Manns, Michael P, Pöhlmann, Stefan, Pietschmann, Thomas, Krey, Thomas, Ciesek, Sandra, Gerold, Gisa, Sodeik, Beate, Becker, Stephan, von Hahn, Thomas

“…Filoviruses infect a wide range of cell types with the exception of lymphocytes. The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and…”
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Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity by Zapatero-Belinchón, Francisco J., Ötjengerdes, Rina, Sheldon, Julie, Schulte, Benjamin, Carriquí-Madroñal, Belén, Brogden, Graham, Arroyo-Fernández, Laura M., Vondran, Florian W. R., Maasoumy, Benjamin, von Hahn, Thomas, Gerold, Gisa

“…The HCV replication cycle is tightly associated with host lipid metabolism: Lipoprotein receptors SR-B1 and LDLr promote entry of HCV, replication is…”
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Fatigue crack closure determination by means of finite element analysis by Zapatero, J., Moreno, B., González-Herrera, A.

“…Plasticity-induced crack closure is an observed phenomenon during fatigue crack growth. However, accurate determination of fatigue crack closure has been a…”
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New approach to stochastic optimal control by JOSA-FOMBELLIDA, R, RINCON-ZAPATERO, J. P

“…This paper provides new insights into the solution of optimal stochastic control problems by means of a system of partial differential equations, which…”
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Numerical study of the effect of plastic wake on plasticity-induced fatigue crack closure by GONZALEZ-HERRERA, A., ZAPATERO, J.

“…ABSTRACT Fatigue crack closure is strongly influenced by the plastic wake developed because of the action of precedent cycles. It is related to the load…”
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High magnification crack-tip field characterisation under biaxial conditions by Moreno, B., Lopez-Crespo, P., Zapatero, J.

“…This work presents a novel methodology for characterising fatigue cracks under biaxial conditions. The methodology uses high magnification Digital Image…”
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Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets by Haid, Sibylle, Matthaei, Alina, Winkler, Melina, Sake, Svenja M, Gunesch, Antonia P, Milke, Vanessa, Köhler, Natalie M, Rückert, Jessica, Vieyres, Gabrielle, Kühl, David, Nguyen, Tu-Trinh, Göhl, Matthias, Lasswitz, Lisa, Zapatero-Belinchón, Francisco J, Brogden, Graham, Gerold, Gisa, Wiegmann, Bettina, Bilitewski, Ursula, Brown, Richard J P, Brönstrup, Mark, Schulz, Thomas F, Pietschmann, Thomas

“…Libraries composed of licensed drugs represent a vast repertoire of molecules modulating physiological processes in humans, providing unique opportunities for…”
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Understanding emerging and re-emerging viruses to facilitate pandemic preparedness by Zapatero-Belinchón, Francisco J., Kumar, Priti, Ott, Melanie, Schwartz, Olivier, Sigal, Alex

“…On 8–11 April 2024, a Keystone meeting on human immunodeficiency virus and emerging and re-emerging viruses convened in Hannover, Germany, aiming to unite…”
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