Search Results - "Zanos, Panos"

Exploring the neurofunctional impairments and cognitive biases concerning food and body related stimuli in anorexia nervosa: An integrated EEG and eye-tracking study protocol by Loizou, Panagiotis, Panagiotou, Georgia, Zanos, Panos, Paraskevopoulos, Evangelos

“…Patients with Anorexia Nervosa (AN) exhibit significant cognitive and neural disturbances compared to healthy individuals when processing food and body-related…”
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Group II metabotropic glutamate receptor blockade promotes stress resilience in mice by Highland, Jaclyn N, Zanos, Panos, Georgiou, Polymnia, Gould, Todd D

“…Stress is a leading risk factor for the onset and recurrence of major depression. Enhancing stress resilience may be a therapeutic strategy to prevent the…”
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One path, two solutions: Network-based analysis identifies targetable pathways for the treatment of comorbid type II diabetes and neuropsychiatric disorders by Onisiforou, Anna, Zanos, Panos

“…Comorbid diseases complicate patient outcomes and escalate healthcare costs, necessitating the need for a deeper mechanistic understanding. Neuropsychiatric…”
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Convergent Mechanisms Underlying Rapid Antidepressant Action by Zanos, Panos, Thompson, Scott M., Duman, Ronald S., Zarate, Carlos A., Gould, Todd D.

“…Traditional pharmacological treatments for depression have a delayed therapeutic onset, ranging from several weeks to months, and there is a high percentage of…”
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Molecular signatures of premature aging in Major Depression and Substance Use Disorders by Onisiforou, Anna, Zanos, Panos, Georgiou, Polymnia

“…Major depressive disorder (MDD) and substance-use disorders (SUDs) often lead to premature aging, increasing vulnerability to cognitive decline and other forms…”
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(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism by Riggs, Lace M, Aracava, Yasco, Zanos, Panos, Fischell, Jonathan, Albuquerque, Edson X, Pereira, Edna F R, Thompson, Scott M, Gould, Todd D

“…Preclinical studies indicate that (2R,6R)-hydroxynorketamine (HNK) retains the rapid and sustained antidepressant-like actions of ketamine, but is spared its…”
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Synthesis and N‑Methyl‑d‑aspartate (NMDA) Receptor Activity of Ketamine Metabolites by Morris, Patrick J, Moaddel, Ruin, Zanos, Panos, Moore, Curtis E, Gould, Todd, Zarate, Carlos A, Thomas, Craig J

“…Ketamine is rapidly metabolized in the human body to a variety of metabolites, including the hydroxy­norketamines. At least two hydroxy­norketamines have…”
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The impact of estradiol on serotonin, glutamate, and dopamine systems by Bendis, Peyton Christine, Zimmerman, Sydney, Onisiforou, Anna, Zanos, Panos, Georgiou, Polymnia

“…Estradiol, the most potent and prevalent member of the estrogen class of steroid hormones and is expressed in both sexes. Functioning as a neuroactive steroid,…”
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Psychological stress enhances tumor growth and diminishes radiation response in preclinical model of lung cancer by Zhang, Yi, Zanos, Panos, Jackson, Isabel L., Zhang, Xiuwu, Zhu, Xiongzhao, Gould, Todd, Vujaskovic, Zeljko

“…•Psychological stress-induced depression increased tumor growth and radioresistance.•Psychological stress activates epithelial-mesenchymal transition…”
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Classical conditioning of antidepressant placebo effects in mice by Krimmel, Samuel R., Zanos, Panos, Georgiou, Polymnia, Colloca, Luana, Gould, Todd D.

“…Introduction Placebo effects in human clinical trials for depression treatment are robust and often comparable to drug effects. Placebo effects are…”
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Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans by Highland, Jaclyn N, Farmer, Cristan A, Zanos, Panos, Lovett, Jacqueline, Zarate, Carlos A, Moaddel, Ruin, Gould, Todd D

“…Background: Ketamine is rapidly metabolized to norketamine and hydroxynorketamine (HNK) metabolites. In female mice, when compared to males, higher levels of…”
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Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer's disease by Onisiforou, Anna, Christodoulou, Christiana C, Zamba-Papanicolaou, Eleni, Zanos, Panos, Georgiou, Polymnia

“…The hippocampus, vital for memory and learning, is among the first brain regions affected in Alzheimer's Disease (AD) and exhibits adult neurogenesis. Women…”
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Unraveling the transcriptomic signatures of Parkinson’s disease and major depression using single-cell and bulk data by Christodoulou, Christiana C., Onisiforou, Anna, Zanos, Panos, Papanicolaou, Eleni Zamba

“…Background Motor symptoms are well-characterized in Parkinson’s disease (PD). However, non-motor symptoms, such as depression, are commonly observed and can…”
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Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search by Bonaventura, Jordi, Gomez, Juan L., Carlton, Meghan L., Lam, Sherry, Sanchez-Soto, Marta, Morris, Patrick J., Moaddel, Ruin, Kang, Hye Jin, Zanos, Panos, Gould, Todd D., Thomas, Craig J., Sibley, David R., Zarate, Carlos A., Michaelides, Michael

“…The off-label use of racemic ketamine and the FDA approval of (S)-ketamine are promising developments for the treatment of depression. Nevertheless, racemic…”
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Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine by Highland, Jaclyn N, Morris, Patrick J, Zanos, Panos, Lovett, Jacqueline, Ghosh, Soumita, Wang, Amy Q, Zarate, Carlos A, Thomas, Craig J, Moaddel, Ruin, Gould, Todd D

“…Background: (R,S)-ketamine has gained attention for its rapid-acting antidepressant actions in patients with treatment-resistant depression. However,…”
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Investigating the shared genetic basis and causal relationships between mucosa-associated lymphoid tissue inflammation and psychiatric disorders by Georgiou, Andrea N, Voskarides, Konstantinos, Zanos, Panos, Chatzittofis, Andreas

“…Chronic and acute inflammation of the mucosa-associated lymphoid tissue have been positively linked to the development of psychiatric disorders in…”
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Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration by Moaddel, Ruin, Zanos, Panos, Farmer, Cristan A., Kadriu, Bashkim, Morris, Patrick J., Lovett, Jacqueline, Acevedo-Diaz, Elia E., Cavanaugh, Grace W., Yuan, Peixiong, Yavi, Mani, Thomas, Craig J., Park, Lawrence T., Ferrucci, Luigi, Gould, Todd D., Zarate, Carlos A.

“…Subanesthetic-dose racemic ( R,S )-ketamine (ketamine) produces rapid, robust, and sustained antidepressant effects in major depressive disorder (MDD) and…”
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Ketamine Mechanism of Action: Separating the Wheat from the Chaff by Gould, Todd D, Zanos, Panos, Zarate, Jr, Carlos A

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Sex-Specific Involvement of Estrogen Receptors in Behavioral Responses to Stress and Psychomotor Activation by Georgiou, Polymnia, Zanos, Panos, Jenne, Carleigh E, Gould, Todd D

“…Fluctuating hormone levels, such as estradiol might underlie the difference in the prevalence of psychiatric disorders observed in women vs. men. Estradiol…”
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Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications by Highland, Jaclyn N., Zanos, Panos, Riggs, Lace M., Georgiou, Polymnia, Clark, Sarah M., Morris, Patrick J., Moaddel, Ruin, Thomas, Craig J., Zarate, Carlos A., Pereira, Edna F. R., Gould, Todd D.

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