Search Results - "Zannis, V. I."

An apolipoprotein E4 fragment affects matrix metalloproteinase 9, tissue inhibitor of metalloproteinase 1 and cytokine levels in brain cell lines by Dafnis, I, Tzinia, A.K, Tsilibary, E.C, Zannis, V.I, Chroni, A

“…Abstract Apolipoprotein (apo) E4 isoform, a major risk factor for Alzheimer disease (AD), is more susceptible to proteolysis than apoE2 and apoE3 isoforms…”
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Mutation in APOA1 predicts increased risk of ischaemic heart disease and total mortality without low HDL cholesterol levels by Haase, C. L., Frikke‐Schmidt, R., Nordestgaard, B. G., Kateifides, A. K., Kardassis, D., Nielsen, L. B., Andersen, C. B., Køber, L., Johnsen, A. H., Grande, P., Zannis, V. I., Tybjærg‐Hansen, A.

“…  Haase CL, Frikke‐Schmidt R, Nordestgaard BG, Kateifides AK, Kardassis D, Nielsen LB, Andersen CB, Køber L, Johnsen AH, Grande P, Zannis VI, Tybjærg‐Hansen A…”
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ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux by Fitzgerald, M.L., Morris, A.L., Chroni, A., Mendez, A.J., Zannis, V.I., Freeman, M.W.

“…Apolipoproteins, such as apolipoprotein A-I (apoA-I), can stimulate cholesterol efflux from cells expressing the ATP binding cassette transporter A1 (ABCA1)…”
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Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, and HDL receptor that mediates selective lipid uptake by Xu, S, Laccotripe, M, Huang, X, Rigotti, A, Zannis, V.I, Krieger, M

“…The class B type I scavenger receptor, SR-BI, binds HDL, mediates selective uptake of HDL cholesteryl esters by cultured cells, and its expression is…”
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Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding by MINNICH, A, COLLET, X, ROGHANI, A, CLADARAS, C, HAMILTON, R. L, FIELDING, C. J, ZANNIS, V. I

“…We have mutagenized the human apoA-I gene and have generated cell lines which express normal and mutant apoA-I forms. Point mutations were introduced which…”
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Promoter elements and factors required for hepatic and intestinal transcription of the human ApoCIII gene by OGAMI, K, HADZOPOULOU-CLADARAS, M, CLADARAS, C, ZANNIS, V. I

“…We have mapped the promoter elements required for hepatic and intestinal transcription of the human apoCIII gene by deletion, nucleotide substitution, and…”
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Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites by Papazafiri, P, Ogami, K, Ramji, D P, Nicosia, A, Monaci, P, Cladaras, C, Zannis, V I

“…DNase I footprinting analysis of the proximal apoA-I promoter sequences with rat liver nuclear extracts identified four protected regions: A, -22 to +17; B,…”
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Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients with degenerative neurological disorders, and from human neoplastic cell lines by Hussain, M.M., Zannis, V.I., Plaitakis, A

“…Glutamate dehydrogenase (GDH) was purified to homogeneity from cerebellar tissue of three normal subjects and seven patients with four distinct types of…”
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Role of Esrrg in the fibrate-mediated regulation of lipid metabolism genes in human ApoA-I transgenic mice by Sanoudou, D, Duka, A, Drosatos, K, Hayes, K C, Zannis, V I

“…We have used a new ApoA-I transgenic mouse model to identify by global gene expression profiling, candidate genes that affect lipid and lipoprotein metabolism…”
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Binding Specificity and Modulation of the ApoA-I Promoter Activity by Homo- and Heterodimers of Nuclear Receptors by Tzameli, I, Zannis, V I

“…Three proximal regulatory elements, AIB, AIC, and AID, of the apoA-I gene are necessary and sufficient for its hepatic expression in vivo and in vitro . DNA…”
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The complete sequence and structural analysis of human apolipoprotein B‐100: relationship between apoB‐100 and apoB‐48 forms by Cladaras, C., Hadzopoulou‐Cladaras, M., Nolte, R.T., Atkinson, D., Zannis, V.I.

“…We have isolated and sequenced overlapping cDNA clones covering the entire sequence of human apolipoprotein B‐100 (apoB‐100). DNA sequence analysis and…”
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Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene by Kardassis, D, Zannis, V I, Cladaras, C

“…The human apolipoprotein B (apoB) promoter region (-150 to +124) is transcriptionally active in HepG2 and CaCo-2 but not in HeLa cells. In the present study,…”
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Apolipoprotein gene expression in the rabbit: abundance, size, and distribution of apolipoprotein mRNA species in different tissues by Lenich, C, Brecher, P, Makrides, S, Chobanian, A, Zannis, V I

“…We have used human apolipoprotein cDNAs as hybridization probes to study the relative abundance and distribution of apolipoprotein mRNAs in rabbit tissues by…”
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Synthesis, intracellular processing, and signal peptide of human apolipoprotein E by Zannis, V I, McPherson, J, Goldberger, G, Karathanasis, S K, Breslow, J L

“…Northern blotting analysis has shown apo-E mRNA synthesis by human liver, HepG2 cells, and primary cultures of human monocyte macrophages but not by the…”
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Mutagenesis of the glycosylation site of human ApoCIII. O-linked glycosylation is not required for ApoCIII secretion and lipid binding by Roghani, A, Zannis, V I

“…We have used site-directed in vitro mutagenesis to alter the codon ACT of human apoCIII gene, specifying Thr-74, to GCT (Ala-74). The normal and mutant apoCIII…”
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Promoter elements and factors required for hepatic transcription of the human ApoA-II gene by CHAMBAZ, J, CARDOT, P, PASTIER, D, ZANNIS, V. I, CLADARAS, C

“…The apolipoprotein A-II (apoA-II) gene regulatory region -911 to +29 strongly promotes the transcription of the promotorless chloramphenicol acetyltransferase…”
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Isolation and Characterization of the Human Apolipoprotein A-I Gene by Karathanasis, Sotirios K., Zannis, Vassilis I., Breslow, Jan L.

“…We have recently shown that an inherited polymorphism occurring in the human apolipoprotein A-I (apo A-I) gene is related to decreased high density lipoprotein…”
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Purification and characterization of the nuclear factor BA1. A transcriptional activator of the human apoB gene by Kardassis, D, Zannis, V I, Cladaras, C

“…The promoter region of human apoB -79 to -63 is recognized by a sequence-specific DNA binding protein, designated NF-BA1, which is essential for the…”
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Expression, secretion, and lipid-binding characterization of the N-terminal 17% of apolipoprotein B by HERSCOVITZ, H, HADZOPOULOU-CLADARAS, M, WALSH, M. T, CLADARAS, C, ZANNIS, V. I, SMALL, D. M

“…The N-terminal 17% of human apolipoprotein B (apoB-17) was expressed in murine C127 cells following transfection with a bovine papilloma virus-based expression…”
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Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes by Zannis, V I, Breslow, J L, Utermann, G, Mahley, R W, Weisgraber, K H, Havel, R J, Goldstein, J L, Brown, M S, Schonfeld, G, Hazzard, W R, Blum, C

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