Search Results - "Zankov, Dimitar P."

Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1 by Ahmat Amin, Mohammad Khusni B., Shimizu, Akio, Zankov, Dimitar P., Sato, Akira, Kurita, Souichi, Ito, Masami, Maeda, Toshinaga, Yoshida, Tetsuya, Sakaue, Tomohisa, Higashiyama, Shigeki, Kawauchi, Akihiro, Ogita, Hisakazu

“…Tumor metastasis is the most common cause of cancer death. Elucidation of the mechanism of tumor metastasis is therefore important in the development of novel,…”
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Novel Therapeutic Role for Dipeptidyl Peptidase III in the Treatment of Hypertension by Pang, Xiaoling, Shimizu, Akio, Kurita, Souichi, Zankov, Dimitar P, Takeuchi, Keisuke, Yasuda-Yamahara, Mako, Kume, Shinji, Ishida, Tetsuo, Ogita, Hisakazu

“…Dipeptidyl peptidase III (DPP III) cleaves dipeptide residues from the N terminus of polypeptides ranging from 3 to 10 amino acids in length and is implicated…”
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Vascular Endothelial Growth Factor-A Exerts Diverse Cellular Effects via Small G Proteins, Rho and Rap by Shimizu, Akio, Zankov, Dimitar P, Kurokawa-Seo, Misuzu, Ogita, Hisakazu

“…Vascular endothelial growth factors (VEGFs) include five molecules (VEGF-A, -B, -C, -D, and placental growth factor), and have various roles that crucially…”
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Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy by Zankov, Dimitar P., Sato, Akira, Shimizu, Akio, Ogita, Hisakazu

“…Background:Pressure overload induces cardiac hypertrophy, which often ends in heart failure. Afadin is an adaptor protein that is ubiquitously expressed and,…”
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KCNE5 (KCNE1L) Variants Are Novel Modulators of Brugada Syndrome and Idiopathic Ventricular Fibrillation by Ohno, Seiko, Zankov, Dimitar P, Ding, Wei-Guang, Itoh, Hideki, Makiyama, Takeru, Doi, Takahiro, Shizuta, Satoshi, Hattori, Tetsuhisa, Miyamoto, Akashi, Naiki, Nobu, Hancox, Jules C, Matsuura, Hiroshi, Horie, Minoru

“…BACKGROUND—Brugada syndrome (BrS) has a significantly higher incidence among the male sex. Among genes coding ion channels and their modulatory proteins, KCNE5…”
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Identification of transmembrane protein 168 mutation in familial Brugada syndrome by Shimizu, Akio, Zankov, Dimitar P., Sato, Akira, Komeno, Masahiro, Toyoda, Futoshi, Yamazaki, Satoru, Makita, Toshinori, Noda, Taichi, Ikawa, Masahito, Asano, Yoshihiro, Miyashita, Yohei, Takashima, Seiji, Morita, Hiroshi, Ishikawa, Taisuke, Makita, Naomasa, Hitosugi, Masahito, Matsuura, Hiroshi, Ohno, Seiko, Horie, Minoru, Ogita, Hisakazu

“…Brugada syndrome (BrS) is an inherited channelopathy responsible for almost 20% of sudden cardiac deaths in patients with nonstructural cardiac diseases…”
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Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage by Zankov, Dimitar P., Shimizu, Akio, Tanaka-Okamoto, Miki, Miyoshi, Jun, Ogita, Hisakazu

“…Adhesive intercellular connections at cardiomyocyte intercalated disks (IDs) support contractile force and maintain structural integrity of the heart muscle…”
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An Adaptor Molecule Afadin Regulates Lymphangiogenesis by Modulating RhoA Activity in the Developing Mouse Embryo by Majima, Takashi, Takeuchi, Keisuke, Sano, Keigo, Hirashima, Masanori, Zankov, Dimitar P, Tanaka-Okamoto, Miki, Ishizaki, Hiroyoshi, Miyoshi, Jun, Ogita, Hisakazu

“…Afadin is an intracellular binding partner of nectins, cell-cell adhesion molecules, and plays important roles in the formation of cell-cell junctions…”
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Significance of serum Zn-α2-glycoprotein for the regulation of blood pressure by Kurita, Souichi, Takeuchi, Keisuke, Hayashi, Yoshimi, Ueyama, Hisao, Zankov, Dimitar P, Pang, Xiaoling, Otsuka, Takanobu, Ohkubo, Iwao, Ogikubo, Osamu, Ogita, Hisakazu

“…Zn-α2-glycoprotein (ZAG) (molecular weight=41 kDa) is one component in the α2 fraction of human plasma, and is reported to be associated with several diseases,…”
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Lipoprotein-Associated Phospholipase A2 Regulates Macrophage Apoptosis via the Akt and Caspase-7 Pathways by Maeda, Toshinaga, Takeuchi, Keisuke, Xiaoling, Pang, Zankov, Dimitar P., Takashima, Naoyuki, Fujiyoshi, Akira, Kadowaki, Takashi, Miura, Katsuyuki, Ueshima, Hirotsugu, Ogita, Hisakazu

“…Aim: Mutations in lipoprotein-associated phospholipase A2 (Lp-PLA2) are related to atherosclerosis. However, the molecular effects of Lp-PLA2 on…”
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Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil by Aiba, Takeshi, Shimizu, Wataru, Inagaki, Masashi, Noda, Takashi, Miyoshi, Shunichiro, Ding, Wei-Guang, Zankov, Dimitar P., Toyoda, Futoshi, Matsuura, Hiroshi, Horie, Minoru, Sunagawa, Kenji

“…We examined the cellular and ionic mechanism for QT prolongation and subsequent Torsade de Pointes (TdP) and the effect of verapamil under conditions mimicking…”
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N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome by Ohno, Seiko, MD, Zankov, Dimitar P., MD, Yoshida, Hidetada, MD, PhD, Tsuji, Keiko, MS, Makiyama, Takeru, MD, Itoh, Hideki, MD, PhD, Akao, Masaharu, MD, PhD, Hancox, Jules C., PhD, Kita, Toru, MD, PhD, Horie, Minoru, MD, PhD

“…Background Long QT syndromes (LQTS) are inherited diseases involving mutations to genes encoding a number of cardiac ion channels and a membrane adaptor…”
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Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients by Zankov, Dimitar P., MD, PhD, Yoshida, Hidetada, MD, PhD, Tsuji, Keiko, MS, Toyoda, Futoshi, PhD, Ding, Wei-Guang, MD, PhD, Matsuura, Hiroshi, MD, PhD, Horie, Minoru, MD, PhD

“…Background KCNH2 gene mutations disrupting rapid component of IK (IKr ) underlie type 2 congenital long QT syndrome (LQT2). Startled auditory stimuli are…”
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RhoA rescues cardiac senescence by regulating Parkin-mediated mitophagy by Soh, Joanne Ern Chi, Shimizu, Akio, Molla, Md Rasel, Zankov, Dimitar P., Nguyen, Le Kim Chi, Khan, Mahbubur Rahman, Tesega, Wondwossen Wale, Chen, Si, Tojo, Misa, Ito, Yoshito, Sato, Akira, Hitosugi, Masahito, Miyagawa, Shigeru, Ogita, Hisakazu

“…Heart failure is one of the leading causes of death worldwide. RhoA, a small GTPase, governs actin dynamics in various tissue and cell types, including…”
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Characterization of the Rapidly Activating Delayed Rectifier Potassium Current, I Kr, in HL-1 Mouse Atrial Myocytes by Toyoda, Futoshi, Ding, Wei-Guang, Zankov, Dimitar P, Omatsu-Kanbe, Mariko, Isono, Takahiro, Horie, Minoru, Matsuura, Hiroshi

“…HL-1 is the adult murine cardiac cell line that can be passaged repeatedly in vitro without losing differentiated phenotype. The present study was designed to…”
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Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation by Yamada, Noriaki, Asano, Yoshihiro, Fujita, Masashi, Yamazaki, Satoru, Inanobe, Atsushi, Matsuura, Norio, Kobayashi, Hatasu, Ohno, Seiko, Ebana, Yusuke, Tsukamoto, Osamu, Ishino, Saki, Takuwa, Ayako, Kioka, Hidetaka, Yamashita, Toru, Hashimoto, Norio, Zankov, Dimitar P, Shimizu, Akio, Asakura, Masanori, Asanuma, Hiroshi, Kato, Hisakazu, Nishida, Yuya, Miyashita, Yohei, Shinomiya, Haruki, Naiki, Nobu, Hayashi, Kenshi, Makiyama, Takeru, Ogita, Hisakazu, Miura, Katsuyuki, Ueshima, Hirotsugu, Komuro, Issei, Yamagishi, Masakazu, Horie, Minoru, Kawakami, Koichi, Furukawa, Tetsushi, Koizumi, Akio, Kurachi, Yoshihisa, Sakata, Yasushi, Minamino, Tetsuo, Kitakaze, Masafumi, Takashima, Seiji

“…BACKGROUND:Bradyarrhythmia is a common clinical manifestation. Although the majority of cases are acquired, genetic analysis of families with bradyarrhythmia…”
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Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of I Ks current in guinea pig atrium by Zankov, Dimitar P., Toyoda, Futoshi, Omatsu-Kanbe, Mariko, Matsuura, Hiroshi, Horie, Minoru

“…A repolarizing conduction in the heart augmented by hyposmotic or mechanically induced membrane stretch is the slow component of delayed rectifier K^sup +^…”
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Actin-Tethered Junctional Complexes in Angiogenesis and Lymphangiogenesis in Association with Vascular Endothelial Growth Factor by Zankov, Dimitar P., Ogita, Hisakazu

“…Vasculature is present in all tissues and therefore is indispensable for development, biology, and pathology of multicellular organisms. Endothelial cells…”
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Blockade of Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidity in Mice With Left Ventricular Hypertrophy by Zhang, Cuntai, Yasuno, Shinji, Kuwahara, Koichiro, Zankov, Dimitar P., Kobori, Atsushi, Makiyama, Takeru, Horie, Minoru

“…Background Stimulation of angiotensin II type 1 (AT1) receptors has been shown to generate the arrhythmogenic substrate in ventricular hypertrophy. We examined…”
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[Ca2+]i Elevation and Oxidative Stress Induce KCNQ1 Protein Translocation from the Cytosol to the Cell Surface and Increase Slow Delayed Rectifier (IKs) in Cardiac Myocytes by Wang, Yuhong, Zankov, Dimitar P., Jiang, Min, Zhang, Mei, Henderson, Scott C., Tseng, Gea-Ny

“…Our goals are to simultaneously determine the three-dimensional distribution patterns of KCNQ1 and KCNE1 in cardiac myocytes and to study the mechanism and…”
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