Production and characterisation of enteric beads

Production and characterisation of enteric beads

Enteric beads have been produced using a purely aqueous system. The method relies on the precipitation of the enteric polymer hydroxypropylmethylcellulose phthalate (HPMCP), when its solutions in an aqueous alkaline media are dropped into an acidic environment. Two compounds, riboflavin and riboflav...

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Bibliographic Details
Published in:International journal of pharmaceutics Vol. 125; no. 1; pp. 151 - 155
Main Authors: Zaniboni, H.C., Fell, J.T., Collett, J.H.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 17-10-1995
Elsevier
Subjects:
Biological and medical sciences
Drug release
Enteric bead
General pharmacology
Medical sciences
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Riboflavin
Drug release
Riboflavin
Enteric bead
Drug
Microsphere
Pharmaceutical technology
Aqueous medium
Preparation
Dosage form
Enteric coating
Release
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Description
Summary:Enteric beads have been produced using a purely aqueous system. The method relies on the precipitation of the enteric polymer hydroxypropylmethylcellulose phthalate (HPMCP), when its solutions in an aqueous alkaline media are dropped into an acidic environment. Two compounds, riboflavin and riboflavin 5-phosphate, representing a poorly soluble and readily soluble compound respectively, have been successfully incorporated in the beads. Drug release studies show that the relatively insoluble compound is well protected in an acidic environment but rapid release occurs when the pH is raised. Solute migration during drying forms a high surface concentration with the soluble material allowing some release in acid.
ISSN:0378-5173
1873-3476
DOI:10.1016/0378-5173(95)00146-A