Search Results - "Zangl, Luke M."

Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy by Jagodinsky, Justin C, Jin, Won Jong, Bates, Amber M, Hernandez, Reinier, Grudzinski, Joseph J, Marsh, Ian R, Chakravarty, Ishan, Arthur, Ian S, Zangl, Luke M, Brown, Ryan J, Nystuen, Erin J, Emma, Sarah E, Kerr, Caroline, Carlson, Peter M, Sriramaneni, Raghava N, Engle, Jonathan W, Aluicio-Sarduy, Eduardo, Barnhart, Todd E, Le, Trang, Kim, KyungMann, Bednarz, Bryan P, Weichert, Jamey P, Patel, Ravi B, Morris, Zachary S

“…Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1…”
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ATM inhibition augments type I interferon response and antitumor T-cell immunity when combined with radiation therapy in murine tumor models by Jin, Won Jong, Zangl, Luke M, Hyun, Meredith, Massoud, Elian, Schroeder, Kaleb, Alexandridis, Roxana A, Morris, Zachary S

“…Radiation therapy (RT) elicits DNA double-strand breaks, resulting in tumor cytotoxicity and a type I interferon (IFN) response via stimulator of interferon…”
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Radiation Augments the Local Anti-Tumor Effect of In Situ Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models by Pieper, Alexander A, Zangl, Luke M, Speigelman, Dan V, Feils, Arika S, Hoefges, Anna, Jagodinsky, Justin C, Felder, Mildred A, Tsarovsky, Noah W, Arthur, Ian S, Brown, Ryan J, Birstler, Jen, Le, Trang, Carlson, Peter M, Bates, Amber M, Hank, Jacquelyn A, Rakhmilevich, Alexander L, Erbe, Amy K, Sondel, Paul M, Patel, Ravi B, Morris, Zachary S

“…Combining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+OX40) is able to generate an effective vaccine in some tumor models, including the A20…”
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Combination of Bempegaldesleukin and Anti-CTLA-4 Prevents Metastatic Dissemination After Primary Resection or Radiotherapy in a Preclinical Model of Non-Small Cell Lung Cancer by Bates, Amber M, Brown, Ryan J, Pieper, Alexander A, Zangl, Luke M, Arthur, Ian, Carlson, Peter M, Le, Trang, Sosa, Gustavo A, Clark, Paul A, Sriramaneni, Raghava N, Kim, KyungMann, Patel, Ravi B, Morris, Zachary S

“…Surgical resection or hypo-fractionated radiation therapy (RT) in early-stage non-small cell lung cancer (NSCLC) achieves local tumor control, but metastatic…”
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Abstract 3060: Temporal analysis of type 1 interferon activation in tumor cells following external beam radiotherapy or targeted radionuclide therapy by Jagodinsky, Justin C., Bates, Amber M., Hernandez, Reinier, Grudzinski, Joseph J., Marsh, Ian R., Chakravarty, Ishan, Arthur, Ian S., Zangl, Luke M., Brown, Ryan J., Nystuen, Erin J., Emma, Sarah E., Kerr, Caroline, Jin, Won Jong, Carlson, Peter M., Engle, Jonathan W., Aluicio-Sarduy, Eduardo, Barnhart, Todd E., Le, Trang, Kim, KyungMann, Bednarz, Bryan P., Weichert, Jamey P., Patel, Ravi B., Morris, Zachary S.

“…Abstract Background: Radiation (RT) activates a type 1 interferon (IFN1) response and this is critical to the effect of RT in priming a response to immune…”
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Abstract 477: Comparing type 1 interferon activation in tumor cells following external beam radiotherapy versus targeted radionuclide therapy by Jagodinsky, Justin C., Arthur, Ian S., Castillo, Juliana S., Chakravarty, Ishan, Zangl, Luke M., Brown, Ryan J., Patel, Ravi B., Jin, Wonjon J., Carlson, Peter M., Hernandez, Reinier, Grudzinski, Joseph J., Marsh, Ian R., Weichert, Jamey P., Bednarz, Bryan P., Morris, Zachary S.

“…Abstract Background: Radiation (RT) activates a type 1 interferon (IFN-1) response and, in preclinical studies, this is critical to the effect of RT in priming…”
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