Search Results - "Zanghi, James"

Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis by Garcia, Samuel, Hartkamp, Linda M, Malvar-Fernandez, B, van Es, Inge E, Lin, Haishan, Wong, Justin, Long, Li, Zanghi, James A, Rankin, Andrew L, Masteller, Emma L, Wong, Brian R, Radstake, Timothy R D J, Tak, Paul P, Reedquist, Kris A

“…CSF-1 or IL-34 stimulation of CSF1R promotes macrophage differentiation, activation and osteoclastogenesis, and pharmacological inhibition of CSF1R is…”
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Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer by Xiang, Hong, Chan, Abigael G, Ahene, Ago, Bellovin, David I, Deng, Rong, Hsu, Amy W, Jeffry, Ursula, Palencia, Servando, Powers, Janine, Zanghi, James, Collins, Helen

“…Bemarituzumab (FPA144) is a first-in-class, humanized, afucosylated immunoglobulin G1 monoclonal antibody (mAb) directed against fibroblast growth factor…”
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A useful model to compare human and mouse growth hormone gene chromosomal structure, expression and regulation, and immune tolerance of human growth hormone analogues by Cattini, Peter A., Bock, Margaret E., Jin, Yan, Zanghi, James A., Vakili, Hana

“…Human (h) pituitary growth hormone (GH) is both physiologically and clinically important. GH reaches its highest circulatory levels in puberty, where it…”
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Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture by Zanghi, James A., Fussenegger, Martin, Bailey, James E.

“…The development of serum‐ and protein‐free Chinese hamster ovary (CHO) cell cultures is a high priority for the production of biopharmaceuticals. Protein‐free…”
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The Growth Factor Inhibitor Suramin Reduces Apoptosis and Cell Aggregation in Protein-Free CHO Cell Batch Cultures by Zanghi, James A., Renner, Wolfgang A., Bailey, James E., Fussenegger, Martin

“…We have previously shown that Chinese hamster ovary (CHO) cells capable of growing in medium free of exogenous proteins die by apoptosis during all stages of a…”
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Immunogenicity of Atezolizumab: Influence of Testing Method and Sampling Frequency on Reported Anti-drug Antibody Incidence Rates by Usdin, Maxime, Quarmby, Valerie, Zanghi, James, Bernaards, Coen, Liao, Laura, Laxamana, Joel, Wu, Benjamin, Swanson, Steven, Song, Yuan, Siguenza, Patty

“…Measurement of anti-drug antibodies (ADA) to assess the incidence of ADA in a clinical trial is a critical step in immunogenicity assessment during the…”
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Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation by FUSSENEGGER, M, FASSNACHT, D, SCHWARTZ, R, ZANGHI, J. A, GRAF, M, BAILEY, J. E, PÖRTNER, R

“…Using multicistronic expression technology we generated a stable Chinese hamster ovary (CHO) cell line (MG12) expressing a model secreted heterologous…”
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Blockade of nonhormonal fibroblast growth factors by FP-1039 inhibits growth of multiple types of cancer by Harding, Thomas C, Long, Li, Palencia, Servando, Zhang, Hongbing, Sadra, Ali, Hestir, Kevin, Patil, Namrata, Levin, Anita, Hsu, Amy W, Charych, Deborah, Brennan, Thomas, Zanghi, James, Halenbeck, Robert, Marshall, Shannon A, Qin, Minmin, Doberstein, Stephen K, Hollenbaugh, Diane, Kavanaugh, W Michael, Williams, Lewis T, Baker, Kevin P

“…The fibroblast growth factor (FGF) pathway promotes tumor growth and angiogenesis in many solid tumors. Although there has long been interest in FGF pathway…”
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Role of Nucleotide Sugar Pools in the Inhibition of NCAM Polysialylation by Ammonia by Zanghi, James A., Mendoza, Thomas P., Schmelzer, Albert E., Knop, Richard H., Miller, William M.

“…Ammonia in animal cell cultures has been shown to specifically inhibit terminal sialylation of N‐ and O‐linked oligosaccharides of glycoproteins. For example,…”
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Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH by Zanghi, J.A, Schmelzer, A.E, Mendoza, T.P, Knop, R.H, Miller, W.M

“…Accumulation of CO2 in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals. By…”
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Ammonia inhibits neural cell adhesion molecule polysialylation in Chinese hamster ovary and small cell lung cancer cells by Zanghi, James A., Mendoza, Thomas P., Knop, Richard H., Miller, William M.

“…Ammonia is a major concern in biotechnology because it often limits recombinant protein production by animal cells. Conditions, such as ammonia accumulation,…”
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Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer by Xiang, Hong, Chan, Abigael G., Ahene, Ago, Bellovin, David I., Deng, Rong, Hsu, Amy W., Jeffry, Ursula, Palencia, Servando, Powers, Janine, Zanghi, James, Collins, Helen

“…Bemarituzumab (FPA144) is a first-in-class, humanized, afucosylated immunoglobulin G1 monoclonal antibody (mAb) directed against fibroblast growth factor…”
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Bicarbonate Concentration and Osmolality Are Key Determinants in the Inhibition of CHO Cell Polysialylation Under Elevated pCO sub(2) or pH by Zanghi, JA, Schmelzer, A E, Mendoza, T P, Knop, R H, Miller, WM

“…Accumulation of CO sub(2) in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals…”
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Effects of cell culture conditions on the polysialylation of the neural cell adhesion molecule in Chinese hamster ovary and small cell lung cancer cells by Zanghi, James Allen

“…Animal cells are important for the production of complex glycoproteins for use in therapeutics and diagnostics. Ammonia and carbon dioxide are major waste…”
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Discrimination of fluorinated uridine metabolites in N-417 small cell lung cancer cell extracts via 19F- and 31P-NMR by Pederson, N V, Zanghi, J A, Miller, W M, Knop, R H

“…31P-NMR extract spectra of N-417 Small Cell Lung Cancer (SCLC) cells cultured with fluorouridine (FUrd) reveal new peaks with chemical shifts in the…”
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