Search Results - "Zanghi, J."
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IMscin001 Part 2: a randomised phase III, open-label, multicentre study examining the pharmacokinetics, efficacy, immunogenicity, and safety of atezolizumab subcutaneous versus intravenous administration in previously treated locally advanced or metastatic non-small-cell lung cancer and pharmacokinetics comparison with other approved indications
Published in Annals of oncology (01-08-2023)“…Atezolizumab intravenous (IV) is approved for the treatment of various solid tumours. To improve treatment convenience and health care efficiencies, a…”
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A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors
Published in Annals of oncology (01-03-2016)“…Fibroblast growth factors (FGFs) play important roles in multiple cancers by supporting tumor growth and angiogenesis. FP-1039 (GSK3052230) is a FGF ligand…”
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Serum protects protein-free competent Chinese hamster ovary cells against apoptosis induced by nutrient deprivation in batch culture
Published in Biotechnology and bioengineering (05-07-1999)“…The development of serum‐ and protein‐free Chinese hamster ovary (CHO) cell cultures is a high priority for the production of biopharmaceuticals. Protein‐free…”
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The Growth Factor Inhibitor Suramin Reduces Apoptosis and Cell Aggregation in Protein-Free CHO Cell Batch Cultures
Published in Biotechnology progress (2000)“…We have previously shown that Chinese hamster ovary (CHO) cells capable of growing in medium free of exogenous proteins die by apoptosis during all stages of a…”
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1447P IMscin001 part 2 updated results: Efficacy, safety, immunogenicity and patient-reported outcomes (PROs) from the randomised phase III study of atezolizumab (atezo) subcutaneous (SC) vs intravenous (IV) in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
Published in Annals of oncology (01-10-2023)Get full text
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Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO(2) or pH
Published in Biotechnology and bioengineering (20-10-1999)“…Accumulation of CO(2) in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals. By…”
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Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation
Published in Cytotechnology (Dordrecht) (2000)“…Using multicistronic expression technology we generated a stable Chinese hamster ovary (CHO) cell line (MG12) expressing a model secreted heterologous…”
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Role of Nucleotide Sugar Pools in the Inhibition of NCAM Polysialylation by Ammonia
Published in Biotechnology progress (01-11-1998)“…Ammonia in animal cell cultures has been shown to specifically inhibit terminal sialylation of N‐ and O‐linked oligosaccharides of glycoproteins. For example,…”
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61MO IMscin001 (part 2: randomized phase III): Pharmacokinetics (PK), efficacy and safety of atezolizumab (atezo) subcutaneous (SC) vs intravenous (IV) in previously treated locally advanced or metastatic non-small cell lung cancer (NSCLC)
Published in Immuno-oncology technology (01-12-2022)Get full text
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Ammonia inhibits neural cell adhesion molecule polysialylation in Chinese hamster ovary and small cell lung cancer cells
Published in Journal of cellular physiology (01-11-1998)“…Ammonia is a major concern in biotechnology because it often limits recombinant protein production by animal cells. Conditions, such as ammonia accumulation,…”
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Tools for decision making on capital expenditures
Published in Journal of healthcare materiel management (01-04-1992)“…The above methods are useful to determine a project's worth. They can provide senior management with information that will be helpful when analyzing potential…”
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Discrimination of fluorinated uridine metabolites in N-417 small cell lung cancer cell extracts via 19F- and 31P-NMR
Published in Magnetic resonance in medicine (01-02-1994)“…31P-NMR extract spectra of N-417 Small Cell Lung Cancer (SCLC) cells cultured with fluorouridine (FUrd) reveal new peaks with chemical shifts in the…”
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Bicarbonate concentration and osmolality are key determinants in the inhibition of CHO cell polysialylation under elevated pCO2 or pH
Published in Biotechnology and bioengineering (20-10-1999)“…Accumulation of CO2 in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals. By…”
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Bicarbonate Concentration and Osmolality Are Key Determinants in the Inhibition of CHO Cell Polysialylation Under Elevated pCO sub(2) or pH
Published in Biotechnology and bioengineering (01-10-1999)“…Accumulation of CO sub(2) in animal cell cultures can be a significant problem during scale-up and production of recombinant glycoprotein biopharmaceuticals…”
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