Search Results - "Zanger, Ulrich"

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation by ZANGER, Ulrich M, SCHWAB, Matthias

“…Cytochromes P450 (CYP) are a major source of variability in drug pharmacokinetics and response. Of 57 putatively functional human CYPs only about a dozen…”
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Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance by Zanger, Ulrich M, Klein, Kathrin

“…Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human liver. Expression is highly variable both between individuals and within…”
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MiR-155 and other microRNAs downregulate drug metabolizing cytochromes P450 in inflammation by Kugler, Nicole, Klein, Kathrin, Zanger, Ulrich M.

“…[Display omitted] In conditions of acute and chronic inflammation hepatic detoxification capacity is severely impaired due to coordinated downregulation of…”
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Systemic regulation of bilirubin homeostasis: Potential benefits of hyperbilirubinemia by Fujiwara, Ryoichi, Haag, Mathias, Schaeffeler, Elke, Nies, Anne T., Zanger, Ulrich M., Schwab, Matthias

“…Neurotoxic bilirubin is the end product of heme catabolism in mammals. Bilirubin is solely conjugated by uridine diphospho‐glucuronosyltransferase 1A1, which…”
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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem by Klein, Kathrin, Zanger, Ulrich M

“…CYP3A4 is the most important drug metabolizing enzyme in adult humans because of its prominent expression in liver and gut and because of its broad substrate…”
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Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions - Focus on Interactions with Cytochromes P450 by Ryu, Chang S, Klein, Kathrin, Zanger, Ulrich M

“…Membrane-associated progesterone receptors (MAPR) are a group of four rather small, partially homologous proteins, which share a similar non-covalent…”
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Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease by Zhang, Yijing, Klein, Kathrin, Sugathan, Aarathi, Nassery, Najlla, Dombkowski, Alan, Zanger, Ulrich M, Waxman, David J

“…Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small…”
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Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation by Zanger, Ulrich M, Turpeinen, Miia, Klein, Kathrin, Schwab, Matthias

“…We investigated the elimination routes for the 200 drugs that are sold most often by prescription count in the United States. The majority (78%) of the…”
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Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D62 and Impaired Allele CYP2D641 by Zanger, Ulrich M., Momoi, Kyoko, Hofmann, Ute, Schwab, Matthias, Klein, Kathrin

“…CYP2D6 metabolizes 20–25% of all clinically used drugs and its complex genetic polymorphism is a major determinant of drug safety and efficacy. We investigated…”
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Breast Cancer Treatment Outcome With Adjuvant Tamoxifen Relative to Patient CYP2D6 and CYP2C19 Genotypes by SCHROTH, Werner, ANTONIADOU, Lydia, FRITZ, Peter, SCHWAB, Matthias, MUERDTER, Thomas, ZANGER, Ulrich M, SIMON, Wolfgang, EICHELBAUM, Michel, BRAUCH, Hiltrud

“…The clinical outcome of tamoxifen-treated breast cancer patients may be influenced by the activity of cytochrome P450 enzymes that catalyze the formation of…”
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The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway by Knebel, Constanze, Heise, Tanja, Zanger, Ulrich M., Lampen, Alfonso, Marx-Stoelting, Philip, Braeuning, Albert

“…Tebuconazole, a member of the triazole group of fungicides, exerts hepatotoxicity in rodent studies. Knowledge on the molecular mechanisms underlying…”
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Expression variability of absorption, distribution, metabolism, excretion-related microRNAs in human liver: influence of nongenetic factors and association with gene expression by Rieger, Jessica K, Klein, Kathrin, Winter, Stefan, Zanger, Ulrich M

“…Genes that are important for the detoxification of drugs and other xenobiotics show a high degree of interindividual variation attributable to regulation by…”
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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver by Nies, Anne T., Koepsell, Hermann, Winter, Stefan, Burk, Oliver, Klein, Kathrin, Kerb, Reinhold, Zanger, Ulrich M., Keppler, Dietrich, Schwab, Matthias, Schaeffeler, Elke

“…An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations and are taken up by organic…”
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A systematic comparison of the impact of inflammatory signaling on absorption, distribution, metabolism, and excretion gene expression and activity in primary human hepatocytes and HepaRG cells by Klein, Marcus, Thomas, Maria, Hofmann, Ute, Seehofer, Daniel, Damm, Georg, Zanger, Ulrich M

“…Inflammatory processes are associated with compromised metabolism and elimination of drugs in the liver, largely mediated by proinflammatory cytokines, such as…”
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Inflammation-associated microRNA-130b down-regulates cytochrome P450 activities and directly targets CYP2C9 by Rieger, Jessica K, Reutter, Sandra, Hofmann, Ute, Schwab, Matthias, Zanger, Ulrich M

“…Expression of genes involved in absorption, distribution, metabolism, and excretion (ADME) of drugs is impaired in pathophysiologic conditions such as…”
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Model-Based Characterization of Inflammatory Gene Expression Patterns of Activated Macrophages by Rex, Julia, Albrecht, Ute, Ehlting, Christian, Thomas, Maria, Zanger, Ulrich M, Sawodny, Oliver, Häussinger, Dieter, Ederer, Michael, Feuer, Ronny, Bode, Johannes G

“…Macrophages are cells with remarkable plasticity. They integrate signals from their microenvironment leading to context-dependent polarization into classically…”
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Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression by Asperger, Hannah, Stamm, Nadia, Gierke, Berthold, Pawlak, Michael, Hofmann, Ute, Zanger, Ulrich M, Marton, Annamaria, Katona, Robert L, Buhala, Andrea, Vizler, Csaba, Cieslik, Jan-Philipp, Ruckhäberle, Eugen, Niederacher, Dieter, Fehm, Tanja, Neubauer, Hans, Ludescher, Marina

“…PGRMC1 (progesterone receptor membrane component 1) is a highly conserved heme binding protein, which is overexpressed especially in hormone receptor-positive…”
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Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group by SCHWAB, Matthias, ZANGER, Ulrich M, BOKEMEYER, Carsten, EICHELBAUM, Michel, MARX, Claudia, SCHAEFFELER, Elke, KLEIN, Kathrin, DIPPON, Jürgen, KERB, Reinhold, BLIEVERNICHT, Julia, FISCHER, Joachim, HOFMANN, Ute

“…To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate…”
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Omics and Drug Response by MEYER, Urs A, ZANGER, Ulrich M, SCHWAB, Matthias

“…A new generation of technologies commonly named omics permits assessment of the entirety of the components of biological systems and produces an explosion of…”
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Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells by Heintze, Tamara, Klein, Kathrin, Hofmann, Ute, Zanger, Ulrich M.

“…HepaRG cells are increasingly accepted as model for human drug metabolism and other hepatic functions. We used lentiviral transduction of undifferentiated…”
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